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    QRFP pyroglutamylated RFamide peptide [ Homo sapiens (human) ]

    Gene ID: 347148, updated on 8-Jul-2021

    Summary

    Official Symbol
    QRFPprovided by HGNC
    Official Full Name
    pyroglutamylated RFamide peptideprovided by HGNC
    Primary source
    HGNC:HGNC:29982
    See related
    Ensembl:ENSG00000188710 MIM:609795
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P518; 26RFa
    Summary
    This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. The encoded products are members of the RFamide family of neuropeptides, characterized by their common protein C-terminus consisting of an arginine (R) and an amidated phenylalanine (F). These products include the neuropeptides 26RFa and the N-terminally extended form, 43RFa. Both of these neuropeptides bind to the pyroglutamylated RFamide peptide receptor (QRFPR) and may regulate blood pressure, reproduction and food intake in rodents. [provided by RefSeq, Jul 2015]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See QRFP in Genome Data Viewer
    Location:
    9q34.12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (130892707..130896812, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (133768094..133772199, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ABL breakpoint recombination region Neighboring gene ribosomal protein L37 pseudogene 17 Neighboring gene ABL proto-oncogene 1, non-receptor tyrosine kinase Neighboring gene Sharpr-MPRA regulatory region 7858 Neighboring gene fibrinogen C domain containing 1 Neighboring gene FIBCD1 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Clone Names

    • MGC119794

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables neuropeptide hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables neuropeptide hormone activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables orexigenic neuropeptide QRFP receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables orexigenic neuropeptide QRFP receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in behavior IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in grooming behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in locomotory behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of blood pressure ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of feeding behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    orexigenic neuropeptide QRFP
    Names
    P518 precursor protein
    RF(Arg-Phe)amide family 26 amino acid peptide (P518)
    prepro-26RFa
    prepro-QRFP

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198180.3NP_937823.1  orexigenic neuropeptide QRFP preproprotein

      See identical proteins and their annotated locations for NP_937823.1

      Status: REVIEWED

      Source sequence(s)
      AB109625, AL161733, CV575364
      Consensus CDS
      CCDS6936.1
      UniProtKB/Swiss-Prot
      P83859
      Related
      ENSP00000485512.1, ENST00000623824.2
      Conserved Domains (1) summary
      pfam11109
      Location:16135
      RFamide_26RFa; Orexigenic neuropeptide Qrfp/P518

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

      Range
      130892707..130896812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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