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    MOGAT3 monoacylglycerol O-acyltransferase 3 [ Homo sapiens (human) ]

    Gene ID: 346606, updated on 12-Oct-2019

    Summary

    Official Symbol
    MOGAT3provided by HGNC
    Official Full Name
    monoacylglycerol O-acyltransferase 3provided by HGNC
    Primary source
    HGNC:HGNC:23249
    See related
    Ensembl:ENSG00000106384 MIM:610184
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DC7; MGAT3; DGAT2L2
    Summary
    Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA (Cheng et al., 2003 [PubMed 12618427]).[supplied by OMIM, Mar 2008]
    Expression
    Biased expression in small intestine (RPKM 14.2), duodenum (RPKM 14.1) and 3 other tissues See more
    Orthologs

    Genomic context

    See MOGAT3 in Genome Data Viewer
    Location:
    7q22.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20190905 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (101192886..101201131, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100839010..100844302, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene VGF nerve growth factor inducible Neighboring gene N-acetyltransferase 16 (putative) Neighboring gene diacylglycerol O-acyltransferase 2 like 7, pseudogene Neighboring gene ribosomal protein SA pseudogene 46

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC119203, MGC119204

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    2-acylglycerol O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    diacylglycerol O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    glycerol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    triglyceride biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    triglyceride biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    triglyceride biosynthetic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    2-acylglycerol O-acyltransferase 3
    Names
    acyl coenzyme A:monoacylglycerol acyltransferase 3
    acyl-CoA:monoacylglycerol acyltransferase 3
    diacylglycerol O-acyltransferase candidate 7
    diacylglycerol acyltransferase 2-like protein 7
    NP_001274076.1
    NP_835470.1
    XP_005250366.1
    XP_011514428.1
    XP_011514429.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287147.2NP_001274076.1  2-acylglycerol O-acyltransferase 3 isoform b

      See identical proteins and their annotated locations for NP_001274076.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AC004876, AY229854, BC100955, BE042458
      Consensus CDS
      CCDS75643.1
      UniProtKB/Swiss-Prot
      Q86VF5
      Related
      ENSP00000368734.3, ENST00000379423.3
      Conserved Domains (1) summary
      cl17185
      Location:45220
      LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
    2. NM_178176.4NP_835470.1  2-acylglycerol O-acyltransferase 3 isoform a

      See identical proteins and their annotated locations for NP_835470.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC004876, AY229854, BE042458
      Consensus CDS
      CCDS5714.1
      UniProtKB/Swiss-Prot
      Q86VF5
      Related
      ENSP00000223114.4, ENST00000223114.9
      Conserved Domains (1) summary
      cl17185
      Location:45340
      LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

      Range
      101192886..101201131 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011516126.2XP_011514428.1  2-acylglycerol O-acyltransferase 3 isoform X2

      Conserved Domains (1) summary
      cl17185
      Location:37304
      LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
    2. XM_011516127.2XP_011514429.1  2-acylglycerol O-acyltransferase 3 isoform X3

      See identical proteins and their annotated locations for XP_011514429.1

      Conserved Domains (1) summary
      cl17185
      Location:4222
      LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
    3. XM_005250309.3XP_005250366.1  2-acylglycerol O-acyltransferase 3 isoform X1

      See identical proteins and their annotated locations for XP_005250366.1

      UniProtKB/Swiss-Prot
      Q86VF5
      Related
      ENSP00000403756.2, ENST00000440203.6
      Conserved Domains (1) summary
      cl17185
      Location:45290
      LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

    RNA

    1. XR_001744700.1 RNA Sequence

    2. XR_001744701.1 RNA Sequence

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