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    IBSP integrin binding sialoprotein [ Homo sapiens (human) ]

    Gene ID: 3381, updated on 8-Jul-2021

    Summary

    Official Symbol
    IBSPprovided by HGNC
    Official Full Name
    integrin binding sialoproteinprovided by HGNC
    Primary source
    HGNC:HGNC:5341
    See related
    Ensembl:ENSG00000029559 MIM:147563
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BSP; BNSP; SP-II; BSP-II
    Summary
    The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See IBSP in Genome Data Viewer
    Location:
    4q22.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (87799554..87812435)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (88720706..88733587)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377324 Neighboring gene IBSP 5' regulatory region Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 7 Neighboring gene matrix extracellular phosphoglycoprotein Neighboring gene heat shock protein 90 alpha family class B member 3, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk.
    GeneReviews: Not available
    GWAS of dental caries patterns in the permanent dentition.
    GeneReviews: Not available

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of integrin-binding sialoprotein (IBSP) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables integrin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in bone mineralization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to growth factor stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in extracellular matrix organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in osteoblast differentiation HDA PubMed 
    involved_in positive regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane HDA PubMed 
    located_in vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    bone sialoprotein 2
    Names
    BSP II
    bone sialoprotein II
    cell-binding sialoprotein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004967.4NP_004958.2  bone sialoprotein 2 precursor

      See identical proteins and their annotated locations for NP_004958.2

      Status: REVIEWED

      Source sequence(s)
      AA452255, AC093768, AI751848, BQ573754, DV462680, J05213
      Consensus CDS
      CCDS3624.1
      UniProtKB/Swiss-Prot
      P21815
      Related
      ENSP00000226284.5, ENST00000226284.7
      Conserved Domains (1) summary
      pfam05432
      Location:17314
      BSP_II; Bone sialoprotein II (BSP-II)

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

      Range
      87799554..87812435
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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