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    papi papi [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33401, updated on 2-Nov-2024

    Summary

    Official Symbol
    papiprovided by FlyBase
    Official Full Name
    papiprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031401
    Locus tag
    Dmel_CG7082
    See related
    AllianceGenome:FB:FBgn0031401
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg7082; CG7082; Dmel\CG7082; Papi; PAPI
    Summary
    Predicted to enable RNA binding activity. Involved in primary piRNA processing and retrotransposon silencing. Located in P granule. Part of protein-containing complex. Is active in mitochondrion. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; germline cell; gonad; and gut section. Used to study azoospermia. Orthologous to human TDRKH (tudor and KH domain containing). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See papi in Genome Data Viewer
    Location:
    22D4-22D4; 2-5 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2220748..2225544)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2220748..2225544)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene missing oocyte Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44114 Neighboring gene sauron

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in P granule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in piRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in piRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in primary piRNA processing IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in retrotransposon silencing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    papi
    Names
    CG7082-PA
    CG7082-PB
    CG7082-PC
    CG7082-PD
    papi-PA
    papi-PB
    papi-PC
    papi-PD
    partner of PIWIs

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2220748..2225544
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164461.2NP_722773.1  papi, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722773.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VQ91
      Related
      FBpp0077508
      Conserved Domains (3) summary
      cd00105
      Location:68127
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00013
      Location:138201
      KH_1; KH domain
      pfam00567
      Location:257386
      TUDOR; Tudor domain
    2. NM_134813.3NP_608657.1  papi, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608657.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VQ91
      Related
      FBpp0077509
      Conserved Domains (3) summary
      cd00105
      Location:68127
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00013
      Location:138201
      KH_1; KH domain
      pfam00567
      Location:257386
      TUDOR; Tudor domain
    3. NM_164462.2NP_722774.1  papi, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722774.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VQ91
      Related
      FBpp0077510
      Conserved Domains (3) summary
      cd00105
      Location:68127
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00013
      Location:138201
      KH_1; KH domain
      pfam00567
      Location:257386
      TUDOR; Tudor domain
    4. NM_164463.2NP_722775.1  papi, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722775.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VQ91
      Related
      FBpp0077511
      Conserved Domains (3) summary
      cd00105
      Location:68127
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00013
      Location:138201
      KH_1; KH domain
      pfam00567
      Location:257386
      TUDOR; Tudor domain