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    HSP90AB1 heat shock protein 90 alpha family class B member 1 [ Homo sapiens (human) ]

    Gene ID: 3326, updated on 21-Apr-2019

    Summary

    Official Symbol
    HSP90AB1provided by HGNC
    Official Full Name
    heat shock protein 90 alpha family class B member 1provided by HGNC
    Primary source
    HGNC:HGNC:5258
    See related
    Ensembl:ENSG00000096384 MIM:140572
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSP84; HSPC2; HSPCB; D6S182; HSP90B
    Summary
    This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]
    Expression
    Ubiquitous expression in ovary (RPKM 514.6), brain (RPKM 324.0) and 25 other tissues See more
    Orthologs

    Genomic context

    See HSP90AB1 in Genome Data Viewer
    Location:
    6p21.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (44246166..44253888)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (44213903..44221625)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene myomixer, myoblast fusion factor Neighboring gene RNA, 7SL, cytoplasmic 811, pseudogene Neighboring gene solute carrier family 29 member 1 (Augustine blood group) Neighboring gene solute carrier family 35 member B2 Neighboring gene microRNA 4647 Neighboring gene NFKB inhibitor epsilon

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Gag-Pol gag-pol HSP90 is incorporated into HIV-1 GagPol virus-like particles PubMed
    Pr55(Gag) gag HSP90 is incorporated into HIV-1 Gag virus-like particles PubMed
    Tat tat HIV-1 Tat downregulates the expression of HSP90 in CD4+ T cells, which may contribute to the impairment of hTERT stability and activation in Tat exposed cells PubMed
    tat Expression of HIV-1 Tat upregulates the abundance of heat shock protein 90kDa alpha (cytosolic), class B member 1 (HSP90AB1) in the nucleoli of Jurkat T-cells PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of heat shock protein 90kDa, class B member 1 (HSP90AB1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
    capsid gag Reduced infectivity of HIV-1 CA mutants can be rescued by HSP90AB1 overexpression. Hyperthermia-induced expression of HSP90AB1 rescues CA-mutant infectivity in nonactivated cells PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human heat shock protein 90kDa alpha (cytosolic), class B member 1 (HSP90AB1: beta; 84 kDa) at amino acid residues 483-484 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Antigen processing and presentation, organism-specific biosystem (from KEGG)
      Antigen processing and presentation, organism-specific biosystem
      Antigen processing and presentation
    • Antigen processing and presentation, conserved biosystem (from KEGG)
      Antigen processing and presentation, conserved biosystem
      Antigen processing and presentation
    • Aryl hydrocarbon receptor signalling, organism-specific biosystem (from REACTOME)
      Aryl hydrocarbon receptor signalling, organism-specific biosystemThe aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that belongs to the basic helix-loop-helix/PER-ARNT-SIM family of DNA binding proteins and controls the expression of a ...
    • Attenuation phase, organism-specific biosystem (from REACTOME)
      Attenuation phase, organism-specific biosystemAttenuation of the heat shock transcriptional response occurs during continuous exposure to intermediate heat shock conditions or upon recovery from stress (Abravaya et al. 1991). The attenuation pha...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Biological oxidations, organism-specific biosystem (from REACTOME)
      Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Cellular response to heat stress, organism-specific biosystem (from REACTOME)
      Cellular response to heat stress, organism-specific biosystemIn response to exposure to elevated temperature and certain other proteotoxic stimuli (e.g., hypoxia, free radicals) cells activate a number of cytoprotective mechanisms known collectively as "heat s...
    • Cellular responses to stress, organism-specific biosystem (from REACTOME)
      Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Estrogen signaling pathway, organism-specific biosystem (from KEGG)
      Estrogen signaling pathway, organism-specific biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
    • Estrogen signaling pathway, conserved biosystem (from KEGG)
      Estrogen signaling pathway, conserved biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
    • Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystem (from REACTOME)
      Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystemPhagocytosis is one of the important innate immune responses that function to eliminate invading infectious agents. Monocytes, macrophages, and neutrophils are the professional phagocytic cells. Phag...
    • Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
      Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
    • Fluid shear stress and atherosclerosis, conserved biosystem (from KEGG)
      Fluid shear stress and atherosclerosis, conserved biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
    • G2/M Transition, organism-specific biosystem (from REACTOME)
      G2/M Transition, organism-specific biosystemCyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of...
    • HSF1 activation, organism-specific biosystem (from REACTOME)
      HSF1 activation, organism-specific biosystemHeat shock factor 1 (HSF1) is a transcription factor that activates gene expression in response to a variety of stresses, including heat shock, oxidative stress, as well as inflammation and infection...
    • HSF1-dependent transactivation, organism-specific biosystem (from REACTOME)
      HSF1-dependent transactivation, organism-specific biosystemAcquisition of DNA binding activity by HSF1 is necessary but insufficient for transcriptional activation (Cotto JJ et al. 1996; Trinklein ND et al. 2004). In addition to having a sequence-specific DN...
    • IL-17 signaling pathway, organism-specific biosystem (from KEGG)
      IL-17 signaling pathway, organism-specific biosystemThe interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defi...
    • IL-17 signaling pathway, conserved biosystem (from KEGG)
      IL-17 signaling pathway, conserved biosystemThe interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defi...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Infectious disease, organism-specific biosystem (from REACTOME)
      Infectious disease, organism-specific biosystem
      Infectious disease
    • Inflammasomes, organism-specific biosystem (from REACTOME)
      Inflammasomes, organism-specific biosystemIn contrast to NOD1/2 some NLRPs function as large macromolecular complexes called 'Inflammasomes'. These multiprotein platforms control activation of the cysteinyl aspartate protease caspase-1 and t...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
      Mitotic G2-G2/M phases, organism-specific biosystem
      Mitotic G2-G2/M phases
    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
      NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NRF2 pathway, organism-specific biosystem (from WikiPathways)
      NRF2 pathway, organism-specific biosystemNRF2 is part of a group of transcription factors called nuclear receptors. It is activated under oxidative stress conditions and subsequently activates several antioxidative genes and proteins.
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
    • Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystem (from REACTOME)
      Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystemThe innate immune system is the first line of defense against invading microorganisms, a broad specificity response characterized by the recruitment and activation of phagocytes and the release of an...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Phase 1 - Functionalization of compounds, organism-specific biosystem (from REACTOME)
      Phase 1 - Functionalization of compounds, organism-specific biosystemPhase 1 of metabolism is concerned with functionalization, that is the introduction or exposure of functional groups on the chemical structure of a compound. This provides a 'handle' for phase 2 conj...
    • Progesterone-mediated oocyte maturation, organism-specific biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, organism-specific biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • Progesterone-mediated oocyte maturation, conserved biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, conserved biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • Prostate cancer, organism-specific biosystem (from KEGG)
      Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Prostate cancer, conserved biosystem (from KEGG)
      Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystem (from REACTOME)
      Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystemThe actin cytoskeleton is fundamental for phagocytosis and members of the Rho family GTPases RAC and CDC42 are involved in actin cytoskeletal regulation leading to pseudopod extension. Active RAC and...
    • Sema3A PAK dependent Axon repulsion, organism-specific biosystem (from REACTOME)
      Sema3A PAK dependent Axon repulsion, organism-specific biosystemActivated Rac1 bound to plexin-A might modulate actin dynamics through the sequential phosphorylation and activation of PAK, LIMK1 and cofilin.
    • Semaphorin interactions, organism-specific biosystem (from REACTOME)
      Semaphorin interactions, organism-specific biosystemSemaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphor...
    • Th17 cell differentiation, organism-specific biosystem (from KEGG)
      Th17 cell differentiation, organism-specific biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
    • Th17 cell differentiation, conserved biosystem (from KEGG)
      Th17 cell differentiation, conserved biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
    • The NLRP3 inflammasome, organism-specific biosystem (from REACTOME)
      The NLRP3 inflammasome, organism-specific biosystemThe NLRP3 (Cryopyrin) inflammasome is currently the best characterized. It consists of NLRP3, ASC (PYCARD) and procaspase-1; CARD8 (Cardinal) is also suggested to be a component. It is activated by a...
    • The role of GTSE1 in G2/M progression after G2 checkpoint, organism-specific biosystem (from REACTOME)
      The role of GTSE1 in G2/M progression after G2 checkpoint, organism-specific biosystemGTSE1 (B99) was identified as a microtubule-associated protein product of the mouse B99 gene, which exhibits both a cell cycle regulated expression, with highest levels in G2, and DNA damage triggere...
    • Uptake and actions of bacterial toxins, organism-specific biosystem (from REACTOME)
      Uptake and actions of bacterial toxins, organism-specific biosystemThe toxic effects of many bacteria on their human hosts are mediated by proteins released from the bacteria that enter human cells and disrupt critical cellular functions (Henkel et al. 2010). All of...
    • Uptake and function of diphtheria toxin, organism-specific biosystem (from REACTOME)
      Uptake and function of diphtheria toxin, organism-specific biosystemDiphtheria is a serious, often fatal human disease associated with damage to many tissues. Bacteria in infected individuals, however, are typically confined to the lining of the throat or to a skin l...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ26984

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ATP-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ATPase activity, coupled TAS
    Traceable Author Statement
    more info
     
    CTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA polymerase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    MHC class II protein complex binding HDA PubMed 
    RNA binding HDA PubMed 
    TPR domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    UTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    cadherin binding HDA PubMed 
    dATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    disordered domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heat shock protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    histone methyltransferase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ion channel binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    nitric-oxide synthase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    peptide binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein dimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    sulfonylurea receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    tau protein binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Fc-gamma receptor signaling pathway involved in phagocytosis TAS
    Traceable Author Statement
    more info
     
    axon extension ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to interleukin-4 IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    central nervous system neuron axonogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    chaperone-mediated protein complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    establishment of cell polarity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell cycle arrest IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of complement-dependent cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of proteasomal protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    negative regulation of transforming growth factor beta activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    placenta development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell size IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cyclin-dependent protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of nitric oxide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of peptidyl-serine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein kinase B signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein localization to cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of tau-protein kinase activity IC
    Inferred by Curator
    more info
     
    positive regulation of telomerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein stabilization TAS
    Traceable Author Statement
    more info
     
    regulation of cellular protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of cellular response to heat TAS
    Traceable Author Statement
    more info
     
    regulation of interferon-gamma-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of type I interferon-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to cocaine IEA
    Inferred from Electronic Annotation
    more info
     
    response to salt stress IEA
    Inferred from Electronic Annotation
    more info
     
    response to unfolded protein NAS
    Non-traceable Author Statement
    more info
    PubMed 
    supramolecular fiber organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    telomerase holoenzyme complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    telomere maintenance via telomerase IDA
    Inferred from Direct Assay
    more info
    PubMed 
    virion attachment to host cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    xenobiotic metabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    colocalizes_with COP9 signalosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    HSP90-CDC37 chaperone complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    aryl hydrocarbon receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axonal growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    brush border membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    dendritic growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extracellular exosome HDA PubMed 
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
     
    inclusion body IEA
    Inferred from Electronic Annotation
    more info
     
    lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    membrane HDA PubMed 
    mitochondrion HDA PubMed 
    neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ooplasm IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    secretory granule lumen TAS
    Traceable Author Statement
    more info
     
    sperm head plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    heat shock protein HSP 90-beta
    Names
    HSP90-beta
    heat shock 84 kDa
    heat shock 90kD protein 1, beta
    heat shock protein 90 kDa
    heat shock protein 90kDa alpha (cytosolic), class B member 1
    heat shock protein 90kDa alpha family class B member 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271969.1NP_001258898.1  heat shock protein HSP 90-beta isoform a

      See identical proteins and their annotated locations for NP_001258898.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a. Variants 1, 2 and 3 encode the same protein (isoform a).
      Source sequence(s)
      AY359878, BE539681, BQ028821, DC350708
      Consensus CDS
      CCDS4909.1
      UniProtKB/Swiss-Prot
      P08238
      UniProtKB/TrEMBL
      A0A024RD80
      Related
      ENSP00000325875.3, ENST00000353801.7
      Conserved Domains (1) summary
      cl27733
      Location:14724
      HSP90; Hsp90 protein
    2. NM_001271970.1NP_001258899.1  heat shock protein HSP 90-beta isoform a

      See identical proteins and their annotated locations for NP_001258899.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform a).
      Source sequence(s)
      BC004928, BE539681, BX420114, DC341882
      Consensus CDS
      CCDS4909.1
      UniProtKB/Swiss-Prot
      P08238
      UniProtKB/TrEMBL
      A0A024RD80
      Related
      ENSP00000481908.1, ENST00000620073.4
      Conserved Domains (1) summary
      cl27733
      Location:14724
      HSP90; Hsp90 protein
    3. NM_001271971.1NP_001258900.1  heat shock protein HSP 90-beta isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR and two alternate in-frame splice sides in the coding region, compared to variant 1. The encoded isoform (b) is shorter compared to isoform a.
      Source sequence(s)
      BC004928, BE539681, BG482327, DC350708
      UniProtKB/Swiss-Prot
      P08238
      Conserved Domains (2) summary
      PTZ00272
      Location:14676
      PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
      pfam00183
      Location:143666
      HSP90; Hsp90 protein
    4. NM_001271972.1NP_001258901.1  heat shock protein HSP 90-beta isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR and uses an alternate in-frame splice site in the internal coding region, compared to variant 1. The encoded isoform (c) is shorter compared to isoform a.
      Source sequence(s)
      AK294643, BC007327, BE539681, DC350708
      UniProtKB/TrEMBL
      B4DGL0, Q6PK50
      Conserved Domains (3) summary
      PTZ00272
      Location:14714
      PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
      pfam00183
      Location:181704
      HSP90; Hsp90 protein
      pfam02518
      Location:40178
      HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
    5. NM_007355.4NP_031381.2  heat shock protein HSP 90-beta isoform a

      See identical proteins and their annotated locations for NP_031381.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform a).
      Source sequence(s)
      BC004928, BE539681, DC340766
      Consensus CDS
      CCDS4909.1
      UniProtKB/Swiss-Prot
      P08238
      UniProtKB/TrEMBL
      A0A024RD80
      Related
      ENSP00000360709.5, ENST00000371646.10
      Conserved Domains (1) summary
      cl27733
      Location:14724
      HSP90; Hsp90 protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

      Range
      44246166..44253888
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024446421.1XP_024302189.1  heat shock protein HSP 90-beta isoform X1

      Related
      ENSP00000360609.1, ENST00000371554.2
      Conserved Domains (1) summary
      cl27733
      Location:14724
      HSP90; Hsp90 protein

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_073528.1: Suppressed sequence

      Description
      NR_073528.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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