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    APC APC regulator of WNT signaling pathway [ Homo sapiens (human) ]

    Gene ID: 324, updated on 6-May-2021

    Summary

    Official Symbol
    APCprovided by HGNC
    Official Full Name
    APC regulator of WNT signaling pathwayprovided by HGNC
    Primary source
    HGNC:HGNC:583
    See related
    Ensembl:ENSG00000134982 MIM:611731
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GS; DP2; DP3; BTPS2; DESMD; DP2.5; PPP1R46
    Summary
    This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Dec 2019]
    Annotation information
    Note: PROC (Gene ID: 5624) and APC (Gene ID: 324) loci share the APC symbol/alias in common. [08 Feb 2019]
    Expression
    Ubiquitous expression in brain (RPKM 25.7), colon (RPKM 4.5) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See APC in Genome Data Viewer
    Location:
    5q22.2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109.20210226 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (112707498..112846239)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (112043195..112181936)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2200 Neighboring gene uncharacterized LOC102467216 Neighboring gene RNA, U6 small nuclear 482, pseudogene Neighboring gene chromobox 3 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 9882 Neighboring gene signal recognition particle 19 Neighboring gene receptor accessory protein 5 Neighboring gene X-box binding protein 1 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Professional guidelines

    Description
    Professional guideline
    ACMG 2013

    The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in APC that are pathogenic or expected to be pathogenic.

    GuidelinePubMed

    Associated conditions

    Description Tests
    Colorectal cancer
    MedGen: C0009402 OMIM: 114500 GeneReviews: Lynch Syndrome
    Compare labs
    Desmoid disease, hereditary
    MedGen: C1851124 OMIM: 135290 GeneReviews: Not available
    Compare labs
    Familial adenomatous polyposis 1 Compare labs
    Familial multiple polyposis syndrome
    MedGen: C0032580 GeneReviews: Not available
    Compare labs
    Gastric adenocarcinoma and proximal polyposis of the stomach
    MedGen: C4749917 OMIM: 619182 GeneReviews: Not available
    not available
    Hepatocellular carcinoma
    MedGen: C2239176 OMIM: 114550 GeneReviews: Not available
    Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2012-07-06)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2012-07-06)

    ClinGen Genome Curation PagePubMed

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: SRP19

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables beta-catenin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NOT enables cadherin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables dynein complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables gamma-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables gamma-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in beta-catenin destruction complex assembly TAS
    Traceable Author Statement
    more info
     
    involved_in beta-catenin destruction complex disassembly TAS
    Traceable Author Statement
    more info
     
    involved_in bicellular tight junction assembly NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cell adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cell fate specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mitotic spindle assembly checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IC
    Inferred by Curator
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of microtubule depolymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in pattern specification process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of protein catabolic process IC
    Inferred by Curator
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of protein localization to centrosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of pseudopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein deubiquitination TAS
    Traceable Author Statement
    more info
     
    involved_in protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of attachment of spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of attachment of spindle microtubules to kinetochore NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of microtubule-based process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    part_of Wnt signalosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    colocalizes_with adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of beta-catenin destruction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of beta-catenin destruction complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of catenin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of catenin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ruffle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    adenomatous polyposis coli protein
    Names
    APC, WNT signaling pathway regulator
    WNT signaling pathway regulator
    adenomatosis polyposis coli tumor suppressor
    adenomatous polyposis coli (APC)
    deleted in polyposis 2.5
    epididymis secretory sperm binding protein
    protein phosphatase 1, regulatory subunit 46
    truncated adenomatosis polyposis coli

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008481.4 RefSeqGene

      Range
      19985..158719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_130

    mRNA and Protein(s)

    1. NM_000038.6NP_000029.2  adenomatous polyposis coli protein isoform b

      See identical proteins and their annotated locations for NP_000029.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant also contains an alternate in-frame exon compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is longer than isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
      Source sequence(s)
      AB210001, CA313732, DA795663, M73548
      Consensus CDS
      CCDS4107.1
      UniProtKB/Swiss-Prot
      P25054
      UniProtKB/TrEMBL
      Q4LE70
      Related
      ENSP00000257430.4, ENST00000257430.9
      Conserved Domains (17) summary
      smart00185
      Location:649689
      ARM; Armadillo/beta-catenin-like repeats
      pfam16689
      Location:455
      APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
      sd00043
      Location:465508
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:16371660
      APC_r; APC repeat
      pfam05924
      Location:20332052
      SAMP; SAMP Motif
      pfam05937
      Location:26702843
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:22232568
      APC_basic; APC basic domain
      pfam11414
      Location:127207
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:7321018
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10361135
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12831368
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16621715
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17461839
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18731947
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl21727
      Location:533734
      VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...
      cl25732
      Location:4272
      SMC_N; RecF/RecN/SMC N terminal domain
      cl25751
      Location:12911701
      DUF4045; Domain of unknown function (DUF4045)
    2. NM_001127510.3NP_001120982.1  adenomatous polyposis coli protein isoform b

      See identical proteins and their annotated locations for NP_001120982.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant also contains an alternate in-frame exon compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is longer than isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
      Source sequence(s)
      AB210001, CA313732, DA795663
      Consensus CDS
      CCDS4107.1
      UniProtKB/Swiss-Prot
      P25054
      UniProtKB/TrEMBL
      Q4LE70
      Related
      ENSP00000427089.2, ENST00000508376.6
      Conserved Domains (17) summary
      smart00185
      Location:649689
      ARM; Armadillo/beta-catenin-like repeats
      pfam16689
      Location:455
      APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
      sd00043
      Location:465508
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:16371660
      APC_r; APC repeat
      pfam05924
      Location:20332052
      SAMP; SAMP Motif
      pfam05937
      Location:26702843
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:22232568
      APC_basic; APC basic domain
      pfam11414
      Location:127207
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:7321018
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10361135
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12831368
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16621715
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17461839
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18731947
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl21727
      Location:533734
      VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...
      cl25732
      Location:4272
      SMC_N; RecF/RecN/SMC N terminal domain
      cl25751
      Location:12911701
      DUF4045; Domain of unknown function (DUF4045)
    3. NM_001127511.3NP_001120983.2  adenomatous polyposis coli protein isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the shorter isoform (a).
      Source sequence(s)
      AB210001, AC136500, AK294544, BP230350, CA313732
      UniProtKB/Swiss-Prot
      P25054
      UniProtKB/TrEMBL
      Q4LE70
      Conserved Domains (13) summary
      cd00020
      Location:593713
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05923
      Location:16191643
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:20162035
      SAMP; SAMP Motif
      pfam05937
      Location:26522825
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:22052550
      APC_basic; APC basic domain
      pfam11414
      Location:137217
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      pfam16629
      Location:7141001
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10181117
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12651350
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16441700
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17211821
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18581929
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      sd00043
      Location:447490
      ARM; armadillo repeat [structural motif]
    4. NM_001354895.2NP_001341824.1  adenomatous polyposis coli protein isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 2 and 3, encodes isoform b.
      Source sequence(s)
      AC008575, AC136500
      Consensus CDS
      CCDS4107.1
      Conserved Domains (17) summary
      smart00185
      Location:649689
      ARM; Armadillo/beta-catenin-like repeats
      pfam16689
      Location:455
      APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
      sd00043
      Location:465508
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:16371660
      APC_r; APC repeat
      pfam05924
      Location:20332052
      SAMP; SAMP Motif
      pfam05937
      Location:26702843
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:22232568
      APC_basic; APC basic domain
      pfam11414
      Location:127207
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:7321018
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10361135
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12831368
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16621715
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17461839
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18731947
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl21727
      Location:533734
      VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...
      cl25732
      Location:4272
      SMC_N; RecF/RecN/SMC N terminal domain
      cl25751
      Location:12911701
      DUF4045; Domain of unknown function (DUF4045)
    5. NM_001354896.2NP_001341825.1  adenomatous polyposis coli protein isoform c

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      Conserved Domains (17) summary
      smart00185
      Location:667707
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:709749
      Arm; Armadillo/beta-catenin-like repeat
      pfam16689
      Location:455
      APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
      sd00043
      Location:581613
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:16551678
      APC_r; APC repeat
      pfam05924
      Location:20512070
      SAMP; SAMP Motif
      pfam05937
      Location:26882861
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:22412586
      APC_basic; APC basic domain
      pfam11414
      Location:127207
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:7501036
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10541153
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:13011386
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16801733
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17641857
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18911965
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25732
      Location:4272
      SMC_N; RecF/RecN/SMC N terminal domain
      cl25751
      Location:13091719
      DUF4045; Domain of unknown function (DUF4045)
    6. NM_001354897.2NP_001341826.1  adenomatous polyposis coli protein isoform d

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      Conserved Domains (15) summary
      smart00185
      Location:659699
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:701741
      Arm; Armadillo/beta-catenin-like repeat
      sd00043
      Location:475518
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:16471670
      APC_r; APC repeat
      pfam05924
      Location:20432062
      SAMP; SAMP Motif
      pfam05937
      Location:26802853
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:22332578
      APC_basic; APC basic domain
      pfam11414
      Location:137217
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:7421028
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10461145
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12931378
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16721725
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17561849
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18831957
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25751
      Location:13011711
      DUF4045; Domain of unknown function (DUF4045)
    7. NM_001354898.2NP_001341827.1  adenomatous polyposis coli protein isoform e

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      Conserved Domains (15) summary
      smart00185
      Location:624664
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:666706
      Arm; Armadillo/beta-catenin-like repeat
      sd00043
      Location:440483
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:16121635
      APC_r; APC repeat
      pfam05924
      Location:20082027
      SAMP; SAMP Motif
      pfam05937
      Location:26452818
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:21982543
      APC_basic; APC basic domain
      pfam11414
      Location:102182
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:707993
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10111110
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12581343
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16371690
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17211814
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18481922
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25751
      Location:12661676
      DUF4045; Domain of unknown function (DUF4045)
    8. NM_001354899.2NP_001341828.1  adenomatous polyposis coli protein isoform f

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      Conserved Domains (16) summary
      smart00185
      Location:621661
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:663703
      Arm; Armadillo/beta-catenin-like repeat
      pfam16689
      Location:455
      APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
      sd00043
      Location:437480
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:16091632
      APC_r; APC repeat
      pfam05924
      Location:20052024
      SAMP; SAMP Motif
      pfam05937
      Location:26422815
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:21952540
      APC_basic; APC basic domain
      pfam11414
      Location:127207
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:704990
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10081107
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12551340
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16341687
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17181811
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18451919
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25751
      Location:12631673
      DUF4045; Domain of unknown function (DUF4045)
    9. NM_001354900.2NP_001341829.1  adenomatous polyposis coli protein isoform g

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      Conserved Domains (15) summary
      smart00185
      Location:608648
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:650690
      Arm; Armadillo/beta-catenin-like repeat
      sd00043
      Location:522554
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:15961619
      APC_r; APC repeat
      pfam05924
      Location:19922011
      SAMP; SAMP Motif
      pfam05937
      Location:26292802
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:21822527
      APC_basic; APC basic domain
      pfam11414
      Location:68148
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:691977
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:9951094
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12421327
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16211674
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17051798
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18321906
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25751
      Location:12501660
      DUF4045; Domain of unknown function (DUF4045)
    10. NM_001354901.2NP_001341830.1  adenomatous polyposis coli protein isoform h

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      Conserved Domains (15) summary
      smart00185
      Location:590630
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:632672
      Arm; Armadillo/beta-catenin-like repeat
      sd00043
      Location:406449
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:15781601
      APC_r; APC repeat
      pfam05924
      Location:19741993
      SAMP; SAMP Motif
      pfam05937
      Location:26112784
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:21642509
      APC_basic; APC basic domain
      pfam11414
      Location:68148
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:673959
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:9771076
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12241309
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16031656
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:16871780
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18141888
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25751
      Location:12321642
      DUF4045; Domain of unknown function (DUF4045)
    11. NM_001354902.2NP_001341831.1  adenomatous polyposis coli protein isoform i

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      Conserved Domains (15) summary
      smart00185
      Location:558598
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:600640
      Arm; Armadillo/beta-catenin-like repeat
      sd00043
      Location:374417
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:15461569
      APC_r; APC repeat
      pfam05924
      Location:19421961
      SAMP; SAMP Motif
      pfam05937
      Location:25792752
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:21322477
      APC_basic; APC basic domain
      pfam11414
      Location:137217
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:641927
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:9451044
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:11921277
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:15711624
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:16551748
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:17821856
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25751
      Location:12001610
      DUF4045; Domain of unknown function (DUF4045)
    12. NM_001354903.2NP_001341832.1  adenomatous polyposis coli protein isoform j

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      Conserved Domains (17) summary
      smart00185
      Location:548588
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:590630
      Arm; Armadillo/beta-catenin-like repeat
      pfam16689
      Location:455
      APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
      sd00043
      Location:364407
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:15361559
      APC_r; APC repeat
      pfam05924
      Location:19321951
      SAMP; SAMP Motif
      pfam05937
      Location:25692742
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:21222467
      APC_basic; APC basic domain
      pfam11414
      Location:127207
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:631917
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:9351034
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:11821267
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:15611614
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:16451738
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:17721846
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25732
      Location:4272
      SMC_N; RecF/RecN/SMC N terminal domain
      cl25751
      Location:11901600
      DUF4045; Domain of unknown function (DUF4045)
    13. NM_001354904.2NP_001341833.1  adenomatous polyposis coli protein isoform k

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      Conserved Domains (15) summary
      smart00185
      Location:523563
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:565605
      Arm; Armadillo/beta-catenin-like repeat
      sd00043
      Location:339382
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:15111534
      APC_r; APC repeat
      pfam05924
      Location:19071926
      SAMP; SAMP Motif
      pfam05937
      Location:25442717
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:20972442
      APC_basic; APC basic domain
      pfam11414
      Location:102182
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:606892
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:9101009
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:11571242
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:15361589
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:16201713
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:17471821
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25751
      Location:11651575
      DUF4045; Domain of unknown function (DUF4045)
    14. NM_001354905.2NP_001341834.1  adenomatous polyposis coli protein isoform l

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      Conserved Domains (15) summary
      smart00185
      Location:489529
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:531571
      Arm; Armadillo/beta-catenin-like repeat
      sd00043
      Location:305348
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:14771500
      APC_r; APC repeat
      pfam05924
      Location:18731892
      SAMP; SAMP Motif
      pfam05937
      Location:25102683
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:20632408
      APC_basic; APC basic domain
      pfam11414
      Location:68148
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:572858
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:876975
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:11231208
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:15021555
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:15861679
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:17131787
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25751
      Location:11311541
      DUF4045; Domain of unknown function (DUF4045)
    15. NM_001354906.2NP_001341835.1  adenomatous polyposis coli protein isoform m

      Status: REVIEWED

      Source sequence(s)
      AC008575, AC136500
      Conserved Domains (14) summary
      smart00185
      Location:366406
      ARM; Armadillo/beta-catenin-like repeats
      pfam00514
      Location:408448
      Arm; Armadillo/beta-catenin-like repeat
      sd00043
      Location:182225
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:13541377
      APC_r; APC repeat
      pfam05924
      Location:17501769
      SAMP; SAMP Motif
      pfam05937
      Location:23872560
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:19402285
      APC_basic; APC basic domain
      pfam16629
      Location:449735
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:753852
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:10001085
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:13791432
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:14631556
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:15901664
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      cl25751
      Location:10081418
      DUF4045; Domain of unknown function (DUF4045)

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

      Range
      112707498..112846239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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