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    Mocs2 molybdenum cofactor synthesis 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294753, updated on 21-Jul-2018

    Summary

    Official Symbol
    Mocs2provided by RGD
    Official Full Name
    molybdenum cofactor synthesis 2provided by RGD
    Primary source
    RGD:1359477
    See related
    Ensembl:ENSRNOG00000056325
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Expression
    Biased expression in Liver (RPKM 403.0), Adrenal (RPKM 365.3) and 9 other tissues See more
    Orthologs

    Genomic context

    See Mocs2 in Genome Data Viewer
    Location:
    2q14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (46980964..46992886)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (71520174..71532084)

    Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene follistatin Neighboring gene uncharacterized LOC103691459 Neighboring gene integrin subunit alpha 2 Neighboring gene integrin subunit alpha 1 Neighboring gene pelota mRNA surveillance and ribosome rescue factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC94220

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    molybdopterin synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    molybdopterin synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to molybdopterin synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    molybdopterin synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    Mo-molybdopterin cofactor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    Mo-molybdopterin cofactor biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    biological_process ND
    No biological Data available
    more info
     
    molybdopterin cofactor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    molybdopterin synthase complex IEA
    Inferred from Electronic Annotation
    more info
     
    molybdopterin synthase complex ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    molybdopterin synthase catalytic subunit
    Names
    MOCS2B
    molybdenum cofactor synthesis protein 2 large subunit
    molybdenum cofactor synthesis protein 2B
    NP_001007634.1
    NP_001155885.1
    XP_006232047.1
    XP_006232048.1
    XP_017446203.1
    XP_017446204.1
    XP_017446205.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007633.2NP_001007634.1  molybdopterin synthase catalytic subunit isoform Mocs2B

      See identical proteins and their annotated locations for NP_001007634.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' end, compared to variant 1, and encodes the large subunit (Mocs2B).
      Source sequence(s)
      BC079181, CO554692, FM123325
      UniProtKB/Swiss-Prot
      Q6AY59
      Related
      ENSRNOP00000069073.1, ENSRNOT00000083668.1
      Conserved Domains (1) summary
      cd00756
      Location:65189
      MoaE; MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
    2. NM_001162413.1NP_001155885.1  molybdopterin synthase catalytic subunit isoform Mocs2A

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the small subunit (Mocs2A).
      Source sequence(s)
      BC079181, CO554692
      UniProtKB/Swiss-Prot
      Q6AY59
      Conserved Domains (1) summary
      cd00754
      Location:788
      MoaD; Ubiquitin domain of MoaD-like proteins

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

      Range
      46980964..46992886
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017590716.1XP_017446205.1  molybdopterin synthase catalytic subunit isoform X2

      UniProtKB/Swiss-Prot
      Q6AY59
      Related
      ENSRNOP00000073722.1, ENSRNOT00000082990.1
      Conserved Domains (1) summary
      cd00756
      Location:65189
      MoaE; MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
    2. XM_017590715.1XP_017446204.1  molybdopterin synthase catalytic subunit isoform X1

    3. XM_006231986.3XP_006232048.1  molybdopterin synthase catalytic subunit isoform X3

      See identical proteins and their annotated locations for XP_006232048.1

      Conserved Domains (1) summary
      cd00756
      Location:54178
      MoaE; MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
    4. XM_006231985.3XP_006232047.1  molybdopterin synthase catalytic subunit isoform X3

      See identical proteins and their annotated locations for XP_006232047.1

      Conserved Domains (1) summary
      cd00756
      Location:54178
      MoaE; MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
    5. XM_017590714.1XP_017446203.1  molybdopterin synthase catalytic subunit isoform X1

    Alternate Rn_Celera

    Genomic

    1. AC_000070.1 Alternate Rn_Celera

      Range
      42260839..42272490
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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