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    Lars leucyl-tRNA synthetase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291624, updated on 21-Jul-2018

    Summary

    Official Symbol
    Larsprovided by RGD
    Official Full Name
    leucyl-tRNA synthetaseprovided by RGD
    Primary source
    RGD:1304962
    See related
    Ensembl:ENSRNOG00000018304 Vega:OTTRNOG00000001717
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Expression
    Biased expression in Muscle (RPKM 219.7), Spleen (RPKM 206.2) and 9 other tissues See more
    Orthologs

    Genomic context

    See Lars in Genome Data Viewer
    Location:
    18p11
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (36524013..36579471, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 18 NC_005117.3 (36191058..36244388, complement)

    Chromosome 18 - NC_005117.4Genomic Context describing neighboring genes Neighboring gene protein transport protein Sec61 subunit gamma pseudogene Neighboring gene SH3 domain containing ring finger 2 Neighboring gene 40S ribosomal protein SA pseudogene Neighboring gene PLAC8-like 1 Neighboring gene RNA binding motif protein 27 Neighboring gene uncharacterized LOC108348775

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC105585

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    aminoacyl-tRNA editing activity IEA
    Inferred from Electronic Annotation
    more info
     
    glutamine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    glutamine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    leucine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    leucine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    aminoacyl-tRNA metabolism involved in translational fidelity IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to amino acid stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to leucine IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to leucine ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to leucine starvation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to leucine starvation ISO
    Inferred from Sequence Orthology
    more info
     
    glutaminyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
     
    glutaminyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
     
    leucyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    leucyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of TORC1 signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    protein targeting to lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    protein targeting to lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell size IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    aminoacyl-tRNA synthetase multienzyme complex IEA
    Inferred from Electronic Annotation
    more info
     
    aminoacyl-tRNA synthetase multienzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endomembrane system ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    leucine--tRNA ligase, cytoplasmic
    Names
    leucyl-tRNA synthetase, cytoplasmic
    NP_001009637.1
    XP_006254734.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009637.1NP_001009637.1  leucine--tRNA ligase, cytoplasmic

      See identical proteins and their annotated locations for NP_001009637.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087655
      UniProtKB/TrEMBL
      Q5PPJ6
      Related
      ENSRNOP00000025284.6, OTTRNOP00000001625, ENSRNOT00000025284.7, OTTRNOT00000002760
      Conserved Domains (5) summary
      cd07959
      Location:757876
      Anticodon_Ia_Leu_AEc; Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases
      cd00812
      Location:527759
      LeuRS_core; catalytic core domain of leucyl-tRNA synthetases
      PLN02959
      Location:51064
      PLN02959; aminoacyl-tRNA ligase
      cl00015
      Location:47231
      nt_trans; nucleotidyl transferase superfamily
      cl12020
      Location:858907
      Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005117.4 Reference Rnor_6.0 Primary Assembly

      Range
      36524013..36579471 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254672.3XP_006254734.1  leucine--tRNA ligase, cytoplasmic isoform X1

      Conserved Domains (5) summary
      cd07959
      Location:757876
      Anticodon_Ia_Leu_AEc; Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases
      cd00812
      Location:527759
      LeuRS_core; catalytic core domain of leucyl-tRNA synthetases
      PLN02959
      Location:51064
      PLN02959; aminoacyl-tRNA ligase
      cl00015
      Location:47231
      nt_trans; nucleotidyl transferase superfamily
      cl12020
      Location:858907
      Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains

    Alternate Rn_Celera

    Genomic

    1. AC_000086.1 Alternate Rn_Celera

      Range
      33798541..33852822 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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