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    ANK2 ankyrin 2 [ Homo sapiens (human) ]

    Gene ID: 287, updated on 7-Oct-2018

    Summary

    Official Symbol
    ANK2provided by HGNC
    Official Full Name
    ankyrin 2provided by HGNC
    Primary source
    HGNC:HGNC:493
    See related
    Ensembl:ENSG00000145362 MIM:106410; Vega:OTTHUMG00000132912
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LQT4; ANK-2; brank-2
    Summary
    This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4 and cardiac arrhythmia syndrome. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2011]
    Expression
    Biased expression in brain (RPKM 29.6), kidney (RPKM 21.6) and 13 other tissues See more
    Orthologs

    Genomic context

    See ANK2 in Genome Data Viewer
    Location:
    4q25-q26
    Exon count:
    60
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (112706018..113383740)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (113739239..114304896)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene oligosaccharyltransferase complex subunit pseudogene 4 Neighboring gene tryptophan rich basic protein pseudogene 1 Neighboring gene ribosomal protein L32 pseudogene 13 Neighboring gene eukaryotic translation initiation factor 2 subunit gamma pseudogene Neighboring gene TATA-box binding protein associated factor 4b pseudogene Neighboring gene ribosomal protein L7a pseudogene 30 Neighboring gene uncharacterized LOC102723896 Neighboring gene uncharacterized LOC105377373 Neighboring gene microRNA 1243 Neighboring gene microRNA 8082 Neighboring gene ribosomal protein S26 pseudogene 25 Neighboring gene uncharacterized LOC105377374 Neighboring gene RNA, 7SL, cytoplasmic 184, pseudogene Neighboring gene RNA, U1 small nuclear 138, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Cardiac arrhythmia, ankyrin B-related
    MedGen: C1970119 OMIM: 600919 GeneReviews: Long QT Syndrome
    Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated (2017-11-22)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated (2017-11-22)

    ClinGen Genome Curation PagePubMed

    NHGRI GWAS Catalog

    Description
    A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
    NHGRI GWA Catalog
    Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants.
    NHGRI GWA Catalog
    Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Asparagine N-linked glycosylation, organism-specific biosystem (from REACTOME)
      Asparagine N-linked glycosylation, organism-specific biosystemN-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley et al. 2009). An early study in 1999 rev...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • COPI-mediated anterograde transport, organism-specific biosystem (from REACTOME)
      COPI-mediated anterograde transport, organism-specific biosystemThe ERGIC (ER-to-Golgi intermediate compartment, also known as vesicular-tubular clusters, VTCs) is a stable, biochemically distinct compartment located adjacent to ER exit sites (Ben-Tekaya et al, 2...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • ER to Golgi Anterograde Transport, organism-specific biosystem (from REACTOME)
      ER to Golgi Anterograde Transport, organism-specific biosystemSecretory cargo destined to be secreted or to arrive at the plasma membrane (PM) leaves the ER via distinct exit sites. This cargo is destined for the Golgi apparatus for further processing.
    • Interaction between L1 and Ankyrins, organism-specific biosystem (from REACTOME)
      Interaction between L1 and Ankyrins, organism-specific biosystemAnkyrins are a family of adaptor proteins that couple membrane proteins such as voltage gated Na+ channels and the Na+/K+ anion exchanger to the spectrin actin cytoskeleton. Ankyrins are encoded by t...
    • L1CAM interactions, organism-specific biosystem (from REACTOME)
      L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
      Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Proteoglycans in cancer, conserved biosystem (from KEGG)
      Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Transport to the Golgi and subsequent modification, organism-specific biosystem (from REACTOME)
      Transport to the Golgi and subsequent modification, organism-specific biosystemAt least two mechanisms of transport of proteins from the ER to the Golgi have been described. One is a general flow requiring no export signals (Wieland et al, 1987; Martinez-Menarguez et al, 1999)....
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ11832, FLJ38277, FLJ46169, DKFZp686P0948, DKFZp686M09125

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ion channel binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ion channel binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ion channel binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding, bridging ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    spectrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    ER to Golgi vesicle-mediated transport TAS
    Traceable Author Statement
    more info
     
    SA node cell action potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    SA node cell to atrial cardiac muscle cell communication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    T-tubule organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    atrial cardiac muscle cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    atrial cardiac muscle cell to AV node cell communication ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    atrial septum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular calcium ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular protein localization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    membrane depolarization during SA node cell action potential TAS
    Traceable Author Statement
    more info
    PubMed 
    paranodal junction assembly IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of calcium ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cation channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of potassium ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of potassium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein localization to M-band ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein localization to T-tubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein localization to cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein localization to endoplasmic reticulum IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein localization to organelle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein localization to plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of SA node cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of atrial cardiac muscle cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of calcium ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    regulation of calcium ion transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cardiac muscle cell contraction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cardiac muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cardiac muscle contraction by calcium ion signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    regulation of heart rate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of heart rate by cardiac conduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of heart rate by cardiac conduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of protein stability IC
    Inferred by Curator
    more info
    PubMed 
    regulation of release of sequestered calcium ion into cytosol IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of ventricular cardiac muscle cell membrane repolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to methylmercury IEA
    Inferred from Electronic Annotation
    more info
     
    sarcoplasmic reticulum calcium ion transport TAS
    Traceable Author Statement
    more info
    PubMed 
    ventricular cardiac muscle cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    A band ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    M band ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    T-tubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Z disc ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    axon initial segment IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    costamere ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    intercalated disc ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    recycling endosome IEA
    Inferred from Electronic Annotation
    more info
     
    sarcolemma ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    ankyrin-2
    Names
    ankyrin 2, neuronal
    ankyrin B
    ankyrin, brain
    ankyrin-2, nonerythrocytic
    non-erythroid ankyrin

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009006.2 RefSeqGene

      Range
      5001..570658
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_327

    mRNA and Protein(s)

    1. NM_001127493.2NP_001120965.1  ankyrin-2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Consensus CDS
      CCDS54796.1
      UniProtKB/Swiss-Prot
      Q01484
      Related
      ENSP00000421067.1, OTTHUMP00000220392, ENST00000506722.5
      Conserved Domains (9) summary
      pfam06390
      Location:16291786
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9571094
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      smart00248
      Location:508533
      ANK; ankyrin repeats
      COG0666
      Location:285483
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:206331
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14731556
      Death_ank2; Death domain of Ankyrin-2
      pfam12796
      Location:216307
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:1663
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:409440
      ANK; ANK repeat [structural motif]
    2. NM_001148.5NP_001139.3  ankyrin-2 isoform 1

      See identical proteins and their annotated locations for NP_001139.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC004057, AC093879, AC093900
      Consensus CDS
      CCDS3702.1
      UniProtKB/Swiss-Prot
      Q01484
      Related
      ENSP00000349588.4, OTTHUMP00000163833, ENST00000357077.8
      Conserved Domains (11) summary
      pfam06390
      Location:37233880
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      pfam09528
      Location:20712594
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      smart00218
      Location:9661103
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      smart00248
      Location:529554
      ANK; ankyrin repeats
      COG0666
      Location:306504
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:227352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:35673650
      Death_ank2; Death domain of Ankyrin-2
      pfam12796
      Location:237328
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:3784
      Ank_4; Ankyrin repeats (many copies)
      pfam15718
      Location:18772169
      DUF4673; Domain of unknown function (DUF4673)
      sd00045
      Location:430461
      ANK; ANK repeat [structural motif]
    3. NM_001354225.1NP_001341154.1  ankyrin-2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:16421799
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9701107
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:227352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14861569
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:499550
      Ank_4; Ankyrin repeats (many copies)
    4. NM_001354228.1NP_001341157.1  ankyrin-2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:16051742
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9661070
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:227352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14491532
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:499550
      Ank_4; Ankyrin repeats (many copies)
    5. NM_001354230.1NP_001341159.1  ankyrin-2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:16311788
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9921096
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:242367
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14751558
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:445476
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:514565
      Ank_4; Ankyrin repeats (many copies)
    6. NM_001354231.1NP_001341160.1  ankyrin-2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:16521789
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9801117
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:242367
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14961579
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:445476
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:514565
      Ank_4; Ankyrin repeats (many copies)
    7. NM_001354232.1NP_001341161.1  ankyrin-2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:16501787
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9781115
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:227352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14941577
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:499550
      Ank_4; Ankyrin repeats (many copies)
    8. NM_001354235.1NP_001341164.1  ankyrin-2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:16371774
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9651102
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:227352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14811564
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:499550
      Ank_4; Ankyrin repeats (many copies)
    9. NM_001354236.1NP_001341165.1  ankyrin-2 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:16041761
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9651069
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:227352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14481531
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:499550
      Ank_4; Ankyrin repeats (many copies)
    10. NM_001354237.1NP_001341166.1  ankyrin-2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:16641821
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9921129
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:242367
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:15081591
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:445476
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:514565
      Ank_4; Ankyrin repeats (many copies)
    11. NM_001354239.1NP_001341168.1  ankyrin-2 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:16281765
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9561093
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:206331
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14721555
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:478529
      Ank_4; Ankyrin repeats (many copies)
    12. NM_001354240.1NP_001341169.1  ankyrin-2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:16531810
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9811118
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:242367
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14971580
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:445476
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:514565
      Ank_4; Ankyrin repeats (many copies)
    13. NM_001354241.1NP_001341170.1  ankyrin-2 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093617, AC093879, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:16531810
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9811118
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:242367
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14971580
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:445476
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:514565
      Ank_4; Ankyrin repeats (many copies)
    14. NM_001354242.1NP_001341171.1  ankyrin-2 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:16521809
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9801117
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:242367
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14961579
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:445476
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:514565
      Ank_4; Ankyrin repeats (many copies)
    15. NM_001354243.1NP_001341172.1  ankyrin-2 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:16171754
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9451082
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:206331
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14611544
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:478529
      Ank_4; Ankyrin repeats (many copies)
    16. NM_001354244.1NP_001341173.1  ankyrin-2 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:16161753
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9441081
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:206331
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14601543
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:478529
      Ank_4; Ankyrin repeats (many copies)
    17. NM_001354245.1NP_001341174.1  ankyrin-2 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:15841741
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9451049
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:227352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14281511
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:565616
      Ank_4; Ankyrin repeats (many copies)
    18. NM_001354246.1NP_001341175.1  ankyrin-2 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:16371794
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9651102
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:227352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14811564
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:499550
      Ank_4; Ankyrin repeats (many copies)
    19. NM_001354249.1NP_001341178.1  ankyrin-2 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:15761733
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9371041
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:198323
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14201503
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:401432
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:470521
      Ank_4; Ankyrin repeats (many copies)
    20. NM_001354252.1NP_001341181.1  ankyrin-2 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:16281785
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9561093
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:206331
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14721555
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:478529
      Ank_4; Ankyrin repeats (many copies)
    21. NM_001354253.1NP_001341182.1  ankyrin-2 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:15631720
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9241028
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:206331
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14071490
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:544595
      Ank_4; Ankyrin repeats (many copies)
    22. NM_001354254.1NP_001341183.1  ankyrin-2 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:16211778
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9491086
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:206331
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14651548
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:478529
      Ank_4; Ankyrin repeats (many copies)
    23. NM_001354255.1NP_001341184.1  ankyrin-2 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:16171774
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9451082
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:206331
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14611544
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:478529
      Ank_4; Ankyrin repeats (many copies)
    24. NM_001354256.1NP_001341185.1  ankyrin-2 isoform 25

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:16161773
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9441081
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:206331
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14601543
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:478529
      Ank_4; Ankyrin repeats (many copies)
    25. NM_001354257.1NP_001341186.1  ankyrin-2 isoform 26

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:15511708
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9121016
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:206331
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:13951478
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:544595
      Ank_4; Ankyrin repeats (many copies)
    26. NM_001354258.1NP_001341187.1  ankyrin-2 isoform 27

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:16051762
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9661070
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:227352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14491532
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:499550
      Ank_4; Ankyrin repeats (many copies)
    27. NM_001354260.1NP_001341189.1  ankyrin-2 isoform 28

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:15431700
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9041008
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:198323
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:13871470
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:401432
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:536587
      Ank_4; Ankyrin repeats (many copies)
    28. NM_001354261.1NP_001341190.1  ankyrin-2 isoform 29

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093617, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:15911748
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9521056
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:213338
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14351518
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:416447
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:485536
      Ank_4; Ankyrin repeats (many copies)
    29. NM_001354262.1NP_001341191.1  ankyrin-2 isoform 30

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:15841741
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9451049
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:206331
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14281511
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:478529
      Ank_4; Ankyrin repeats (many copies)
    30. NM_001354264.1NP_001341193.1  ankyrin-2 isoform 31

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:15831740
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9371041
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:198323
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14271510
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:401432
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:470521
      Ank_4; Ankyrin repeats (many copies)
    31. NM_001354265.1NP_001341194.1  ankyrin-2 isoform 32

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:16371794
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9651102
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:227352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14811564
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:499550
      Ank_4; Ankyrin repeats (many copies)
    32. NM_001354266.1NP_001341195.1  ankyrin-2 isoform 33

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:15761733
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9371041
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:198323
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14201503
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:401432
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:470521
      Ank_4; Ankyrin repeats (many copies)
    33. NM_001354267.1NP_001341196.1  ankyrin-2 isoform 33

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:15761733
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9371041
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:198323
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14201503
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:401432
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:470521
      Ank_4; Ankyrin repeats (many copies)
    34. NM_001354268.1NP_001341197.1  ankyrin-2 isoform 35

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:15721729
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9331037
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:227352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14161499
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:565616
      Ank_4; Ankyrin repeats (many copies)
    35. NM_001354269.1NP_001341198.1  ankyrin-2 isoform 36

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093900, AC106864
      Conserved Domains (7) summary
      pfam06390
      Location:15671724
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:8951032
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      COG0666
      Location:1092
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:223348
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14111494
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:624655
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:188249
      Ank_4; Ankyrin repeats (many copies)
    36. NM_001354270.1NP_001341199.1  ankyrin-2 isoform 37

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:15631720
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9241028
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:206331
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14071490
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:544595
      Ank_4; Ankyrin repeats (many copies)
    37. NM_001354271.1NP_001341200.1  ankyrin-2 isoform 38

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:15431700
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9041008
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:198323
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:13871470
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:401432
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:536587
      Ank_4; Ankyrin repeats (many copies)
    38. NM_001354272.1NP_001341201.1  ankyrin-2 isoform 39

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:15951752
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9561060
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:206331
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14391522
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:478529
      Ank_4; Ankyrin repeats (many copies)
    39. NM_001354273.1NP_001341202.1  ankyrin-2 isoform 40

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:15381695
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:8991003
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:227352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:13821465
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:628659
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:192253
      Ank_4; Ankyrin repeats (many copies)
    40. NM_001354274.1NP_001341203.1  ankyrin-2 isoform 41

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:15601697
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9321036
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:198323
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14041487
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:401432
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:470521
      Ank_4; Ankyrin repeats (many copies)
    41. NM_001354275.1NP_001341204.1  ankyrin-2 isoform 42

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:15841741
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9451049
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:206331
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14281511
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:409440
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:478529
      Ank_4; Ankyrin repeats (many copies)
    42. NM_001354276.1NP_001341205.1  ankyrin-2 isoform 43

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:15761733
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9371041
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:198323
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14201503
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:401432
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:470521
      Ank_4; Ankyrin repeats (many copies)
    43. NM_001354277.1NP_001341206.1  ankyrin-2 isoform 44

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC017007, AC093900
      Conserved Domains (6) summary
      pfam06390
      Location:15101667
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:871975
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:198323
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:13541437
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:599630
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:666718
      Ank_4; Ankyrin repeats (many copies)
    44. NM_001354278.1NP_001341207.1  ankyrin-2 isoform 45

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093900
      Related
      ENSP00000422853.1, ENST00000514960.5
      Conserved Domains (3) summary
      pfam06390
      Location:814971
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:175279
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08804
      Location:658741
      Death_ank2; Death domain of Ankyrin-2
    45. NM_001354279.1NP_001341208.1  ankyrin-2 isoform 46

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093900
      Conserved Domains (3) summary
      pfam06390
      Location:826983
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:187291
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08804
      Location:670753
      Death_ank2; Death domain of Ankyrin-2
    46. NM_001354280.1NP_001341209.1  ankyrin-2 isoform 47

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093900
      Conserved Domains (3) summary
      pfam06390
      Location:821978
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:175279
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08804
      Location:665748
      Death_ank2; Death domain of Ankyrin-2
    47. NM_001354281.1NP_001341210.1  ankyrin-2 isoform 48

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093900
      Consensus CDS
      CCDS87250.1
      Related
      ENSP00000426944.1, ENST00000509550.5
      Conserved Domains (3) summary
      pfam06390
      Location:814971
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:175279
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08804
      Location:658741
      Death_ank2; Death domain of Ankyrin-2
    48. NM_001354282.1NP_001341211.1  ankyrin-2 isoform 49

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093900
      Conserved Domains (3) summary
      pfam06390
      Location:826983
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:187291
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08804
      Location:670753
      Death_ank2; Death domain of Ankyrin-2
    49. NM_020977.4NP_066187.2  ankyrin-2 isoform 2

      See identical proteins and their annotated locations for NP_066187.2

      Status: REVIEWED

      Source sequence(s)
      AC004057, AC093879, AC093900
      Consensus CDS
      CCDS43261.1
      UniProtKB/Swiss-Prot
      Q01484
      Related
      ENSP00000378044.3, OTTHUMP00000163834, ENST00000394537.7
      Conserved Domains (8) summary
      pfam06390
      Location:16381795
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9661103
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      smart00248
      Location:529554
      ANK; ankyrin repeats
      cd00204
      Location:227352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14821565
      Death_ank2; Death domain of Ankyrin-2
      pfam12796
      Location:237328
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:3784
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:430461
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

      Range
      112706018..113383740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017008071.2XP_016863560.1  ankyrin-2 isoform X4

    2. XM_017008074.2XP_016863563.1  ankyrin-2 isoform X7

    3. XM_017008075.2XP_016863564.1  ankyrin-2 isoform X8

    4. XM_017008072.2XP_016863561.1  ankyrin-2 isoform X5

    5. XM_017008080.2XP_016863569.1  ankyrin-2 isoform X18

    6. XM_017008077.2XP_016863566.1  ankyrin-2 isoform X10

    7. XM_024454021.1XP_024309789.1  ankyrin-2 isoform X17

      Conserved Domains (6) summary
      pfam06390
      Location:16041761
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9651069
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:227352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14481531
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:499550
      Ank_4; Ankyrin repeats (many copies)
    8. XM_024454016.1XP_024309784.1  ankyrin-2 isoform X3

      Conserved Domains (11) summary
      pfam06390
      Location:37353849
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9781115
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:227352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:35793662
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:499550
      Ank_4; Ankyrin repeats (many copies)
      pfam15402
      Location:24582599
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
      cl26247
      Location:31613407
      DNA_pol3_delta2; DNA polymerase III, delta subunit
      cl26305
      Location:29963530
      XPG_I; XPG I-region
      cl26511
      Location:15452172
      Neuromodulin_N; Gap junction protein N-terminal region
      cl28033
      Location:16901969
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    9. XM_024454017.1XP_024309785.1  ankyrin-2 isoform X12

      Conserved Domains (6) summary
      pfam06390
      Location:16501787
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9781115
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:227352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14941577
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:499550
      Ank_4; Ankyrin repeats (many copies)
    10. XM_017008073.2XP_016863562.1  ankyrin-2 isoform X6

    11. XM_017008076.2XP_016863565.1  ankyrin-2 isoform X9

    12. XM_017008078.2XP_016863567.1  ankyrin-2 isoform X13

    13. XM_005262945.3XP_005263002.1  ankyrin-2 isoform X11

      Conserved Domains (12) summary
      pfam06390
      Location:36903847
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      pfam09528
      Location:20382561
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      smart00218
      Location:9661070
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      smart00248
      Location:529554
      ANK; ankyrin repeats
      COG0666
      Location:306504
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:227352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:35343617
      Death_ank2; Death domain of Ankyrin-2
      pfam06583
      Location:16911962
      Neogenin_C; Neogenin C-terminus
      pfam12796
      Location:237328
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:3784
      Ank_4; Ankyrin repeats (many copies)
      pfam15718
      Location:18442136
      DUF4673; Domain of unknown function (DUF4673)
      sd00045
      Location:430461
      ANK; ANK repeat [structural motif]
    14. XM_024454018.1XP_024309786.1  ankyrin-2 isoform X14

      Conserved Domains (6) summary
      pfam06390
      Location:16051742
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9661070
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:227352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14491532
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:499550
      Ank_4; Ankyrin repeats (many copies)
    15. XM_024454020.1XP_024309788.1  ankyrin-2 isoform X16

      Conserved Domains (6) summary
      pfam06390
      Location:16051762
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9661070
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:227352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14491532
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:499550
      Ank_4; Ankyrin repeats (many copies)
    16. XM_024454022.1XP_024309790.1  ankyrin-2 isoform X19

      Conserved Domains (6) summary
      pfam06390
      Location:15841741
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9451049
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:227352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14281511
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:565616
      Ank_4; Ankyrin repeats (many copies)
    17. XM_024454023.1XP_024309791.1  ankyrin-2 isoform X20

      Conserved Domains (6) summary
      pfam06390
      Location:15381695
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:8991003
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:227352
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:13821465
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:628659
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:192253
      Ank_4; Ankyrin repeats (many copies)
    18. XM_024454019.1XP_024309787.1  ankyrin-2 isoform X15

      Conserved Domains (6) summary
      pfam06390
      Location:16311788
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      smart00218
      Location:9921096
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd00204
      Location:242367
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08804
      Location:14751558
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:445476
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:514565
      Ank_4; Ankyrin repeats (many copies)
    19. XM_017008067.1XP_016863556.1  ankyrin-2 isoform X1

    20. XM_017008069.1XP_016863558.1  ankyrin-2 isoform X2

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