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    INTS1 integrator complex subunit 1 [ Homo sapiens (human) ]

    Gene ID: 26173, updated on 5-Jan-2022

    Summary

    Official Symbol
    INTS1provided by HGNC
    Official Full Name
    integrator complex subunit 1provided by HGNC
    Primary source
    HGNC:HGNC:24555
    See related
    Ensembl:ENSG00000164880 MIM:611345
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    INT1; NET28; NDCAGF
    Summary
    INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in testis (RPKM 20.1), kidney (RPKM 10.8) and 25 other tissues See more
    Orthologs
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    Genomic context

    See INTS1 in Genome Data Viewer
    Location:
    7p22.3
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (1470277..1504389, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (1509913..1544025, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene MICAL like 2 Neighboring gene Sharpr-MPRA regulatory region 1985 Neighboring gene MICALL2 divergent transcript Neighboring gene INTS1-MAFK intergenic CAGE-defined mid-level expression enhancer Neighboring gene uncharacterized LOC100128653 Neighboring gene Sharpr-MPRA regulatory region 13805 Neighboring gene MAF bZIP transcription factor K

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ46624, KIAA1440, DKFZp586J0619

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in U2 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in snRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of integrator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane HDA PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    integrator complex subunit 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080453.3NP_001073922.2  integrator complex subunit 1

      See identical proteins and their annotated locations for NP_001073922.2

      Status: VALIDATED

      Source sequence(s)
      AB037861, AC093734, AI935093, BC069262, BF346658, BM547069, BM553299, BX324321, DB113520
      Consensus CDS
      CCDS47526.1
      UniProtKB/Swiss-Prot
      Q8N201
      Related
      ENSP00000385722.3, ENST00000404767.8
      Conserved Domains (1) summary
      pfam12432
      Location:350430
      DUF3677; Protein of unknown function (DUF3677)

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

      Range
      1470277..1504389 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017011960.1XP_016867449.1  integrator complex subunit 1 isoform X2

    2. XM_011515260.1XP_011513562.1  integrator complex subunit 1 isoform X3

      Conserved Domains (1) summary
      pfam12432
      Location:350430
      DUF3677; Protein of unknown function (DUF3677)
    3. XM_017011959.1XP_016867448.1  integrator complex subunit 1 isoform X1

    4. XM_011515262.2XP_011513564.1  integrator complex subunit 1 isoform X4

      Conserved Domains (1) summary
      pfam12432
      Location:350430
      DUF3677; Protein of unknown function (DUF3677)

    RNA

    1. XR_001744624.1 RNA Sequence

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