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    UNC50 unc-50 inner nuclear membrane RNA binding protein [ Homo sapiens (human) ]

    Gene ID: 25972, updated on 15-Jun-2019

    Summary

    Official Symbol
    UNC50provided by HGNC
    Official Full Name
    unc-50 inner nuclear membrane RNA binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:16046
    See related
    Ensembl:ENSG00000115446 MIM:617826
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    URP; GMH1; UNCL; HSD23; PDLs22
    Expression
    Ubiquitous expression in thyroid (RPKM 28.7), testis (RPKM 24.9) and 25 other tissues See more
    Orthologs

    Genomic context

    See UNC50 in Genome Data Viewer
    Location:
    2q11.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (98608548..98618515)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (99225032..99234978)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate-4-phosphatase type I A Neighboring gene cytochrome c oxidase assembly factor 5 Neighboring gene alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A Neighboring gene YWHAQ pseudogene 5 Neighboring gene uncharacterized LOC107985922

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp564G0222

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein unc-50 homolog
    Names
    geal-6 membrane-associated high-copy suppressor 1
    periodontal ligament-specific protein 22
    protein GMH1 homolog
    unc-50 related
    unc-50-like protein
    uncoordinated-like protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330353.2NP_001317282.1  protein unc-50 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC010134, AC064860
      Conserved Domains (1) summary
      pfam05216
      Location:32226
      UNC-50; UNC-50 family
    2. NM_001330354.1NP_001317283.1  protein unc-50 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC010134, AC064860
      Consensus CDS
      CCDS82485.1
      UniProtKB/TrEMBL
      J3KQ47
      Related
      ENSP00000386466.1, ENST00000409347.5
      Conserved Domains (1) summary
      pfam05216
      Location:49270
      UNC-50; UNC-50 family
    3. NM_014044.6NP_054763.2  protein unc-50 homolog isoform 3

      See identical proteins and their annotated locations for NP_054763.2

      Status: VALIDATED

      Source sequence(s)
      AC010134, AK222599, BC091481
      Consensus CDS
      CCDS2035.1
      UniProtKB/Swiss-Prot
      Q53HI1
      UniProtKB/TrEMBL
      A0A0S2Z612
      Related
      ENSP00000350409.2, ENST00000357765.6
      Conserved Domains (1) summary
      pfam05216
      Location:34255
      UNC-50; UNC-50 family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      98608548..98618515
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006712403.3XP_006712466.1  protein unc-50 homolog isoform X1

      Conserved Domains (1) summary
      pfam05216
      Location:49243
      UNC-50; UNC-50 family
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