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    QPCT glutaminyl-peptide cyclotransferase [ Homo sapiens (human) ]

    Gene ID: 25797, updated on 6-Sep-2021

    Summary

    Official Symbol
    QPCTprovided by HGNC
    Official Full Name
    glutaminyl-peptide cyclotransferaseprovided by HGNC
    Primary source
    HGNC:HGNC:9753
    See related
    Ensembl:ENSG00000115828 MIM:607065
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    QC; GCT; sQC
    Summary
    This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in adrenal (RPKM 75.9), bone marrow (RPKM 17.6) and 13 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See QPCT in Genome Data Viewer
    Location:
    2p22.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (37344630..37373322)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (37571773..37600465)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene PRKD3 divergent transcript Neighboring gene RNA, U6 small nuclear 939, pseudogene Neighboring gene uncharacterized LOC107985868 Neighboring gene VISTA enhancer hs1480

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
    GeneReviews: Not available
    Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
    GeneReviews: Not available
    Investigation of single nucleotide polymorphisms and biological pathways associated with response to TNFα inhibitors in patients with rheumatoid arthritis.
    GeneReviews: Not available

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables glutaminyl-peptide cyclotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables glutaminyl-peptide cyclotransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metalloexopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    glutaminyl-peptide cyclotransferase
    Names
    EC
    glutaminyl cyclase
    glutaminyl-tRNA cyclotransferase
    glutamyl cyclase
    NP_036545.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012413.4NP_036545.1  glutaminyl-peptide cyclotransferase precursor

      See identical proteins and their annotated locations for NP_036545.1

      Status: REVIEWED

      Source sequence(s)
      BC020456, BC047756, BF970452, BI755122
      Consensus CDS
      CCDS1790.1
      UniProtKB/Swiss-Prot
      Q16769
      Related
      ENSP00000344829.3, ENST00000338415.8
      Conserved Domains (1) summary
      cd03880
      Location:51358
      M28_QC_like; M28 Zn-Peptidase Glutaminyl Cyclase

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      37344630..37373322
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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