Format

Send to:

Choose Destination
    • Showing Current items.

    Rasa1 RAS p21 protein activator 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25676, updated on 5-Aug-2018

    Summary

    Official Symbol
    Rasa1provided by RGD
    Official Full Name
    RAS p21 protein activator 1provided by RGD
    Primary source
    RGD:3537
    See related
    Ensembl:ENSRNOG00000029185
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GAPX; Rasa
    Summary
    may play a role in Ras GTPase mediated signal transduction; may be involved in cell proliferation and cell migration [RGD, Feb 2006]
    Expression
    Biased expression in Thymus (RPKM 226.3), Heart (RPKM 215.1) and 9 other tissues See more
    Orthologs

    Genomic context

    See Rasa1 in Genome Data Viewer
    Location:
    2q11
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (13617021..13696531, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (13470580..13551782, complement)

    Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene similar to transcriptional adaptor 3-like Neighboring gene cyclin H Neighboring gene uncharacterized LOC102555062 Neighboring gene AT-rich interactive domain-containing protein 4A-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    ion channel binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    phosphotyrosine residue binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
     
    platelet-derived growth factor receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    platelet-derived growth factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase B binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    actin cytoskeleton organization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    activation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    blood vessel morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    blood vessel morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cell adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cellular response to epidermal growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to fibroblast growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to platelet-derived growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    male genitalia development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    mitotic cytokinesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell-matrix adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of neuron apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of glucose import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of actin filament polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to drug IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to insulin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    vasculogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle IEA
    Inferred from Electronic Annotation
    more info
     
    ruffle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ras GTPase-activating protein 1
    Names
    GAP
    GTPase-activating protein
    RAS p21 protein activator (GTPase activating protein) 1
    p120GAP
    rasGAP

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013135.1NP_037267.1  ras GTPase-activating protein 1

      See identical proteins and their annotated locations for NP_037267.1

      Status: PROVISIONAL

      Source sequence(s)
      L13151
      UniProtKB/Swiss-Prot
      P50904
      Related
      ENSRNOP00000047300.2, ENSRNOT00000046251.2
      Conserved Domains (8) summary
      cd08400
      Location:582707
      C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
      cd10353
      Location:152255
      SH2_Nterm_RasGAP; N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
      cd10354
      Location:341417
      SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
      cd11788
      Location:272330
      SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1
      cd05391
      Location:7051036
      RasGAP_p120GAP; Ras-GTPase Activating Domain of p120
      smart00323
      Location:6891035
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13260
      Location:480567
      PH_RASA1; RAS p21 protein activator (GTPase activating protein) 1 Pleckstrin homology (PH) domain
      pfam00169
      Location:480568
      PH; PH domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

      Range
      13617021..13696531 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000070.1 Alternate Rn_Celera

      Range
      12124725..12204755 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center