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    Foxa3 forkhead box A3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25100, updated on 2-Oct-2018

    Summary

    Official Symbol
    Foxa3provided by RGD
    Official Full Name
    forkhead box A3provided by RGD
    Primary source
    RGD:2809
    See related
    Ensembl:ENSRNOG00000014256
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hnf3g
    Summary
    member of the Forkhead box a (Foxa) transcription factor family; binds rat proglucagon gene G2 promoter element [RGD, Feb 2006]
    Expression
    Biased expression in Liver (RPKM 197.7) and Testes (RPKM 29.0) See more
    Orthologs

    Genomic context

    See Foxa3 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (79921292..79930219, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (81181104..81190030, complement)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene Myb-related transcription factor, partner of profilin Neighboring gene interferon regulatory factor 2 binding protein 1 Neighboring gene symplekin Neighboring gene hematological and neurological expressed 1 protein pseudogene Neighboring gene radial spoke head 6 homolog A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Maturity onset diabetes of the young, organism-specific biosystem (from KEGG)
      Maturity onset diabetes of the young, organism-specific biosystemAbout 2-5% of type II diabetic patients suffer from a monogenic disease with autosomal dominant inheritance. This monogenic form of type II diabetes is called maturity onset diabetes of the young (MO...
    • Maturity onset diabetes of the young, conserved biosystem (from KEGG)
      Maturity onset diabetes of the young, conserved biosystemAbout 2-5% of type II diabetic patients suffer from a monogenic disease with autosomal dominant inheritance. This monogenic form of type II diabetes is called maturity onset diabetes of the young (MO...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription regulatory region DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    anatomical structure morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    cellular glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    cellular glucose homeostasis TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to starvation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of hepatocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    hepatocyte nuclear factor 3-gamma
    Names
    HNF-3-gamma
    HNF-3G
    forkhead box protein A3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017077.2NP_058773.1  hepatocyte nuclear factor 3-gamma

      See identical proteins and their annotated locations for NP_058773.1

      Status: PROVISIONAL

      Source sequence(s)
      L09648
      UniProtKB/Swiss-Prot
      P32183
      Related
      ENSRNOP00000019219.1, ENSRNOT00000019219.3
      Conserved Domains (1) summary
      smart00339
      Location:119207
      FH; FORKHEAD

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      79921292..79930219 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      73128615..73137542 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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