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    Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25086, updated on 12-Aug-2018

    Summary

    Official Symbol
    Cyp2e1provided by RGD
    Official Full Name
    cytochrome P450, family 2, subfamily e, polypeptide 1provided by RGD
    Primary source
    RGD:2475
    See related
    Ensembl:ENSRNOG00000012458
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cyp2e
    Summary
    facilitates hepatocyte sensitization to tumor necrosis factor-alpha (TNF-alpha)-mediated cell death; may play a role in xenobiotic metabolism [RGD, Feb 2006]
    Expression
    Biased expression in Liver (RPKM 11351.2) and Kidney (RPKM 1709.8) See more
    Orthologs

    Genomic context

    See Cyp2e1 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (213511892..213522195)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (220405975..220416727)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene olfactory receptor pseudogene 314 Neighboring gene olfactory receptor 315 Neighboring gene uncharacterized LOC103691262 Neighboring gene synaptonemal complex central element protein 1 Neighboring gene similar to transmembrane protein 49

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    FMN binding IC
    Inferred by Curator
    more info
    PubMed 
    arachidonic acid epoxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    heme binding ISO
    Inferred from Sequence Orthology
    more info
     
    heme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    monooxygenase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
    Inferred from Electronic Annotation
    more info
     
    steroid hydroxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    drug metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    drug metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    epoxygenase P450 pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    exogenous drug catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    heterocycle metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    heterocycle metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    monoterpenoid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    monoterpenoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    organic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    oxidation-reduction process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    oxidation-reduction process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process ISO
    Inferred from Sequence Orthology
    more info
     
    response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organonitrogen compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to ozone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    steroid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    triglyceride metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    xenobiotic metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    xenobiotic metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intrinsic component of endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cytochrome P450 2E1
    Names
    4-nitrophenol 2-hydroxylase
    CYPIIE1
    P450-J
    P450RLM6
    cytochrome P450 subfamily 2e1 (ethanol-inducible)
    cytochrome P450, subfamily 2E, polypeptide 1
    cytochrome P450-J
    cytochrome P450RLM6
    NP_113731.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031543.1NP_113731.1  cytochrome P450 2E1

      See identical proteins and their annotated locations for NP_113731.1

      Status: PROVISIONAL

      Source sequence(s)
      J02627
      UniProtKB/Swiss-Prot
      P05182
      Related
      ENSRNOP00000016883.3, ENSRNOT00000016883.6
      Conserved Domains (1) summary
      pfam00067
      Location:33489
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      213511892..213522195
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      193484404..193494772
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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