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    Fmo4 flavin containing dimethylaniline monoxygenase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246247, updated on 13-Aug-2019

    Summary

    Official Symbol
    Fmo4provided by RGD
    Official Full Name
    flavin containing dimethylaniline monoxygenase 4provided by RGD
    Primary source
    RGD:628601
    See related
    Ensembl:ENSRNOG00000003400
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Expression
    Biased expression in Kidney (RPKM 503.9), Liver (RPKM 55.5) and 1 other tissue See more
    Orthologs

    Genomic context

    See Fmo4 in Genome Data Viewer
    Location:
    13q22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (80685385..80703575, complement)
    106 current Rn_Celera (GCF_000002265.2) 13 AC_000081.1 (74892262..74910106, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 13 NC_005112.3 (85580299..85598234, complement)

    Chromosome 13 - NC_005112.4Genomic Context describing neighboring genes Neighboring gene proline-rich coiled-coil 2C Neighboring gene uncharacterized LOC102555344 Neighboring gene uncharacterized LOC102555487 Neighboring gene flavin containing dimethylaniline monoxygenase 1 Neighboring gene uncharacterized LOC103692017 Neighboring gene flavin containing dimethylaniline monoxygenase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC93155

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    N,N-dimethylaniline monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    NADP binding IEA
    Inferred from Electronic Annotation
    more info
     
    flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    monooxygenase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    drug catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    drug catabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dimethylaniline monooxygenase [N-oxide-forming] 4
    Names
    FMO 4
    dimethylaniline oxidase 4
    flavin containing monooxygenase 4
    hepatic flavin-containing monooxygenase 4
    NP_653147.1
    NP_653148.1
    XP_006250206.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144561.2NP_653147.1  dimethylaniline monooxygenase [N-oxide-forming] 4 long isoform

      See identical proteins and their annotated locations for NP_653147.1

      Status: PROVISIONAL

      Source sequence(s)
      AF458416
      UniProtKB/Swiss-Prot
      Q8K4B7
      Related
      ENSRNOP00000004599.2, ENSRNOT00000004599.5
      Conserved Domains (2) summary
      pfam00743
      Location:2531
      FMO-like; Flavin-binding monooxygenase-like
      cl21454
      Location:89220
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    2. NM_144562.1NP_653148.1  dimethylaniline monooxygenase [N-oxide-forming] 4 short isoform

      See identical proteins and their annotated locations for NP_653148.1

      Status: PROVISIONAL

      Source sequence(s)
      AF458417
      UniProtKB/TrEMBL
      Q8K4B6
      Related
      ENSRNOP00000004577.4, ENSRNOT00000004577.6
      Conserved Domains (2) summary
      pfam00743
      Location:2468
      FMO-like; Flavin-binding monooxygenase-like
      cl21454
      Location:46157
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005112.4 Reference Rnor_6.0 Primary Assembly

      Range
      80685385..80703575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250144.3XP_006250206.1  dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X1

      See identical proteins and their annotated locations for XP_006250206.1

      UniProtKB/Swiss-Prot
      Q8K4B7
      Conserved Domains (2) summary
      pfam00743
      Location:2531
      FMO-like; Flavin-binding monooxygenase-like
      cl21454
      Location:5342
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    Alternate Rn_Celera

    Genomic

    1. AC_000081.1 Alternate Rn_Celera

      Range
      74892262..74910106 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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