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    Cat catalase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24248, updated on 12-Aug-2018

    Summary

    Official Symbol
    Catprovided by RGD
    Official Full Name
    catalaseprovided by RGD
    Primary source
    RGD:2279
    See related
    Ensembl:ENSRNOG00000008364
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CS1; Cas1; Catl; Cs-1; Cat01
    Summary
    functions as a hydrogen peroxide:hydrogen peroxide reductase [RGD, Feb 2006]
    Expression
    Biased expression in Liver (RPKM 3517.9), Kidney (RPKM 1744.6) and 6 other tissues See more
    Orthologs

    Genomic context

    See Cat in Genome Data Viewer
    Location:
    3q32
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (93379872..93412058, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (100021857..100054043, complement)

    Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene ets homologous factor Neighboring gene uncharacterized LOC102548892 Neighboring gene E74 like ETS transcription factor 5 Neighboring gene 60S ribosomal protein L7a pseudogene Neighboring gene uncharacterized LOC108350423 Neighboring gene 40S ribosomal protein S10 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NADP binding IEA
    Inferred from Electronic Annotation
    more info
     
    NADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    aminoacylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    aminoacylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    antioxidant activity ISO
    Inferred from Sequence Orthology
    more info
     
    catalase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    catalase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    catalase activity ISO
    Inferred from Sequence Orthology
    more info
     
    catalase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    heme binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on peroxide as acceptor ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    UV protection IEA
    Inferred from Electronic Annotation
    more info
     
    UV protection ISO
    Inferred from Sequence Orthology
    more info
     
    aerobic respiration IEA
    Inferred from Electronic Annotation
    more info
     
    aerobic respiration ISO
    Inferred from Sequence Orthology
    more info
     
    aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    hemoglobin metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    hemoglobin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    hydrogen peroxide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    hydrogen peroxide catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hydrogen peroxide catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hydrogen peroxide catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein tetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    response to L-ascorbic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to UV IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to activity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to auditory stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to fatty acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hydrogen peroxide IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to hyperoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to inactivity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to insulin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lead ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to light intensity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    response to ozone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to phenylpropanoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to radiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to reactive oxygen species IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
     
    response to toxic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to vitamin A IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to vitamin E IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    triglyceride metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    triglyceride metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    ureteric bud development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peroxisome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peroxisome ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012520.2NP_036652.1  catalase

      See identical proteins and their annotated locations for NP_036652.1

      Status: VALIDATED

      Source sequence(s)
      BC081853, FM043772
      UniProtKB/Swiss-Prot
      P04762
      Related
      ENSRNOP00000011230.4, ENSRNOT00000011230.5
      Conserved Domains (2) summary
      cd08156
      Location:68497
      catalase_clade_3; Clade 3 of the heme-binding enzyme catalase
      COG0753
      Location:17493
      KatE; Catalase [Inorganic ion transport and metabolism]

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

      Range
      93379872..93412058 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000071.1 Alternate Rn_Celera

      Range
      88911241..88943392 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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