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    Sept3 septin 3 [ Mus musculus (house mouse) ]

    Gene ID: 24050, updated on 12-Aug-2018
    Official Symbol
    Sept3provided by MGI
    Official Full Name
    septin 3provided by MGI
    Primary source
    MGI:MGI:1345148
    See related
    Ensembl:ENSMUSG00000022456
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sep3; AV154067; 3110018K01Rik; B530002E20Rik
    Expression
    Biased expression in CNS E14 (RPKM 82.2), whole brain E14.5 (RPKM 81.1) and 6 other tissues See more
    See Sept3 in Genome Data Viewer
    Location:
    15; 15 E1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (82274935..82294574)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (82105365..82124872)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1500009C09 gene Neighboring gene predicted gene, 46500 Neighboring gene WBP2 N-terminal like Neighboring gene N-acetyl galactosaminidase, alpha

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
      Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
      Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex scaffold activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    septin ring assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    presynaptic cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    presynaptic cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    septin filament array IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    synapse IEA
    Inferred from Electronic Annotation
    more info
     

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358836.1NP_001345765.1  neuronal-specific septin-3 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC104325
      Conserved Domains (1) summary
      cd01850
      Location:59333
      CDC_Septin; CDC/Septin GTPase family
    2. NM_001358837.1NP_001345766.1  neuronal-specific septin-3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 3' coding region, which results in an early stop codon, compared to variant 1. The resulting protein (isoform 2) has a shorter, distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC104325
      Conserved Domains (1) summary
      cd01850
      Location:59333
      CDC_Septin; CDC/Septin GTPase family
    3. NM_011889.3NP_036019.2  neuronal-specific septin-3 isoform 3

      See identical proteins and their annotated locations for NP_036019.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, has multiple coding region differences, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC104325
      Consensus CDS
      CCDS37157.1
      UniProtKB/Swiss-Prot
      Q9Z1S5
      Related
      ENSMUSP00000112124.1, ENSMUST00000116423.2
      Conserved Domains (1) summary
      cd01850
      Location:46320
      CDC_Septin; CDC/Septin GTPase family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      82274935..82294574
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316609.1XP_017172098.1  neuronal-specific septin-3 isoform X3

      Conserved Domains (1) summary
      cd01850
      Location:59333
      CDC_Septin; CDC/Septin GTPase family
    2. XM_006520992.1XP_006521055.1  neuronal-specific septin-3 isoform X3

      Related
      ENSMUSP00000155480.1, ENSMUST00000230365.1
      Conserved Domains (1) summary
      cd01850
      Location:59333
      CDC_Septin; CDC/Septin GTPase family
    3. XM_017316607.1XP_017172096.1  neuronal-specific septin-3 isoform X1

      Conserved Domains (1) summary
      cd01850
      Location:59333
      CDC_Septin; CDC/Septin GTPase family
    4. XM_017316610.1XP_017172099.1  neuronal-specific septin-3 isoform X4

    5. XM_017316608.1XP_017172097.1  neuronal-specific septin-3 isoform X2

      Conserved Domains (1) summary
      cd01850
      Location:59332
      CDC_Septin; CDC/Septin GTPase family
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