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    NUP188 nucleoporin 188 [ Homo sapiens (human) ]

    Gene ID: 23511, updated on 7-Aug-2021

    Summary

    Official Symbol
    NUP188provided by HGNC
    Official Full Name
    nucleoporin 188provided by HGNC
    Primary source
    HGNC:HGNC:17859
    See related
    Ensembl:ENSG00000095319 MIM:615587
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    hNup188; KIAA0169; SANDSTEF
    Summary
    The nuclear pore complex (NPC) is found on the nuclear envelope and forms a gateway that regulates the flow of proteins and RNAs between the cytoplasm and nucleoplasm. The NPC is comprised of approximately 30 distinct proteins collectively known as nucleoporins. Nucleoporins are pore-complex-specific glycoproteins which often have cytoplasmically oriented O-linked N-acetylglucosamine residues and numerous repeats of the pentapeptide sequence XFXFG. However, the nucleoporin protein encoded by this gene does not contain the typical FG repeat sequences found in most vertebrate nucleoporins. This nucleoporin is thought to form part of the scaffold for the central channel of the nuclear pore. [provided by RefSeq, Jan 2013]
    Expression
    Broad expression in testis (RPKM 47.7), skin (RPKM 10.9) and 23 other tissues See more
    Orthologs
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    Genomic context

    See NUP188 in Genome Data Viewer
    Location:
    9q34.11
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (128947699..129007096)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (131709978..131769375)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene phytanoyl-CoA dioxygenase domain containing 1 Neighboring gene dolichol kinase Neighboring gene uncharacterized LOC101929314 Neighboring gene SH3 domain containing GRB2 like, endophilin B2 Neighboring gene mitoguardin 2 Neighboring gene dolichyldiphosphatase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: PHYHD1

    Homology

    Clone Names

    • FLJ21639

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in RNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in membrane HDA PubMed 
    located_in nuclear envelope TAS
    Traceable Author Statement
    more info
     
    part_of nuclear pore inner ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    nucleoporin NUP188
    Names
    nucleoporin 188kDa
    nucleoporin NUP188 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033111.1 RefSeqGene

      Range
      5007..64404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_015354.3NP_056169.1  nucleoporin NUP188

      See identical proteins and their annotated locations for NP_056169.1

      Status: REVIEWED

      Source sequence(s)
      AA731883, D79991, HY094051
      Consensus CDS
      CCDS35156.1
      UniProtKB/Swiss-Prot
      Q5SRE5
      Related
      ENSP00000361658.2, ENST00000372577.2
      Conserved Domains (1) summary
      pfam10487
      Location:31941
      Nup188; Nucleoporin subcomplex protein binding to Pom34

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

      Range
      128947699..129007096
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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