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    MAST2 microtubule associated serine/threonine kinase 2 [ Homo sapiens (human) ]

    Gene ID: 23139, updated on 5-Mar-2024

    Summary

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    Official Symbol
    MAST2provided by HGNC
    Official Full Name
    microtubule associated serine/threonine kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:19035
    See related
    Ensembl:ENSG00000086015 MIM:612257; AllianceGenome:HGNC:19035
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MTSSK; MAST205
    Summary
    Enables phosphatase binding activity. Predicted to be involved in several processes, including peptidyl-serine phosphorylation; regulation of interleukin-12 production; and spermatid differentiation. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in microtubule cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 25.4), heart (RPKM 11.8) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    1p34.1
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (45803612..46036122)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (45680810..45913311)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (46269284..46501794)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378693 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 835 Neighboring gene ribosomal protein L6 pseudogene 1 Neighboring gene MPRA-validated peak201 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:46304499-46305000 Neighboring gene Sharpr-MPRA regulatory region 10352 Neighboring gene uncharacterized LOC105378694 Neighboring gene translation machinery associated 16 homolog pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 5403 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:46392868-46393561 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:46406659-46407160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:46407161-46407660 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 836 Neighboring gene MPRA-validated peak202 silencer Neighboring gene P3R3URF-PIK3R3 readthrough Neighboring gene OCT4 hESC enhancer GRCh37_chr1:46502635-46503136 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:46508718-46509562 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:46509563-46510406 Neighboring gene uncharacterized LOC124904171 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:46527714-46528913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 990 Neighboring gene phosphoinositide-3-kinase regulatory subunit 3 Neighboring gene COX7B pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. MAST1 variant causes mega-corpus-callosum syndrome with cortical malformations but without cerebellar hypoplasia. Rodríguez-García ME, et al. Am J Med Genet A, 2020 Jun. PMID 32198973
    2. High MAST2 mRNA expression and its role in diagnosis and prognosis of liver cancer. Jiao Y, et al. Sci Rep, 2019 Dec 27. PMID 31882722, Free PMC Article
    3. A Screen for Genomic Disorders of Infertility Identifies MAST2 Duplications Associated with Nonobstructive Azoospermia in Humans. Huang N, et al. Biol Reprod, 2015 Sep. PMID 26203179, Free PMC Article
    4. Deciphering the unconventional peptide binding to the PDZ domain of MAST2. Delhommel F, et al. Biochem J, 2015 Jul 1. PMID 25942057
    5. Transcriptional regulation of human-specific SVAF₁ retrotransposons by cis-regulatory MAST2 sequences. Zabolotneva AA, et al. Gene, 2012 Aug 15. PMID 22609064

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A rare coding mutation in the MAST2 gene causes venous thrombosis in a French family with unexplained thrombophilia: The Breizh MAST2 Arg89Gln variant.
      Title: A rare coding mutation in the MAST2 gene causes venous thrombosis in a French family with unexplained thrombophilia: The Breizh MAST2 Arg89Gln variant.
    2. MAST1 variant causes mega-corpus-callosum syndrome with cortical malformations but without cerebellar hypoplasia.
      Title: MAST1 variant causes mega-corpus-callosum syndrome with cortical malformations but without cerebellar hypoplasia.
    3. High MAST2 mRNA expression and its role in diagnosis and prognosis of liver cancer.
      Title: High MAST2 mRNA expression and its role in diagnosis and prognosis of liver cancer.
    4. we observed 3 case-specific duplications of the autosomal gene MAST2, and in a replication phase we found another 11 duplications
      Title: A Screen for Genomic Disorders of Infertility Identifies MAST2 Duplications Associated with Nonobstructive Azoospermia in Humans.
    5. Viral and PTEN peptide interactions to MAST2-PDZ occur via a unique kinetic step which involves both canonical C-terminal PBM binding and N-terminal anchoring.
      Title: Deciphering the unconventional peptide binding to the PDZ domain of MAST2.
    6. MAST2 gene rearrangements occur in invasive breast carcinoma.
      Title: MAST2 and NOTCH1 translocations in breast carcinoma and associated pre-invasive lesions.
    7. MAST205 plays an important role in regulating CFTR expression and function
      Title: MAST205 competes with cystic fibrosis transmembrane conductance regulator (CFTR)-associated ligand for binding to CFTR to regulate CFTR-mediated fluid transport.
    8. The MAST2 sequence at the 5' end of SVA(F1) acts as a positive transcriptional regulator in human germ cells.
      Title: Transcriptional regulation of human-specific SVAF₁ retrotransposons by cis-regulatory MAST2 sequences.
    9. Overexpression of MAST1 or MAST2 gene fusions has a proliferative effect both in vitro and in vivo in breast cancer cell lines.
      Title: Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer.
    10. Recruitment of a MAST2 CpG island was most likely beneficial to the hybrid retrotransposons because it could significantly increase retrotransposition frequency.
      Title: Novel family of human transposable elements formed due to fusion of the first exon of gene MAST2 with retrotransposon SVA.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ39200, KIAA0807

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of interleukin-12 production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatid differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    microtubule-associated serine/threonine-protein kinase 2
    Names
    microtubule associated testis specific serine/threonine protein kinase
    NP_001306174.1
    NP_001311249.1
    NP_001311250.1
    NP_055927.2
    XP_005270712.1
    XP_005270713.1
    XP_006710540.1
    XP_011539361.1
    XP_011539363.1
    XP_011539364.1
    XP_011539365.1
    XP_011539366.1
    XP_011539369.1
    XP_011539370.1
    XP_011539371.1
    XP_016856241.1
    XP_016856242.1
    XP_016856244.1
    XP_047306052.1
    XP_047306061.1
    XP_047306067.1
    XP_047306072.1
    XP_047306077.1
    XP_047306078.1
    XP_047306079.1
    XP_047306085.1
    XP_047306086.1
    XP_047306094.1
    XP_047306097.1
    XP_047306098.1
    XP_047306101.1
    XP_047306105.1
    XP_047306106.1
    XP_047306109.1
    XP_054191305.1
    XP_054191306.1
    XP_054191307.1
    XP_054191308.1
    XP_054191309.1
    XP_054191310.1
    XP_054191311.1
    XP_054191312.1
    XP_054191313.1
    XP_054191314.1
    XP_054191315.1
    XP_054191316.1
    XP_054191317.1
    XP_054191318.1
    XP_054191319.1
    XP_054191320.1
    XP_054191321.1
    XP_054191322.1
    XP_054191323.1
    XP_054191324.1
    XP_054191325.1
    XP_054191326.1
    XP_054191327.1
    XP_054191328.1
    XP_054191329.1
    XP_054191330.1
    XP_054191331.1
    XP_054191332.1
    XP_054191333.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001319245.2 → NP_001306174.1  microtubule-associated serine/threonine-protein kinase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AB047005, AL358075, AL603882, BC065499
      UniProtKB/Swiss-Prot
      Q6P0Q8
      Conserved Domains (4) summary
      smart00220
      Location:512 → 785
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:1105 → 1186
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:511 → 790
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:201 → 475
      DUF1908; Domain of unknown function (DUF1908)

    2. NM_001324320.2 → NP_001311249.1  microtubule-associated serine/threonine-protein kinase 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL358075, AL603882, AL603888, AL645480
      Conserved Domains (4) summary
      smart00220
      Location:519 → 792
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:1112 → 1193
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:518 → 797
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:201 → 482
      DUF1908; Domain of unknown function (DUF1908)

    3. NM_001324321.2 → NP_001311250.1  microtubule-associated serine/threonine-protein kinase 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL358075, AL603888, AL645480
      Conserved Domains (4) summary
      smart00220
      Location:358 → 631
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:951 → 1032
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:357 → 636
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:40 → 321
      DUF1908; Domain of unknown function (DUF1908)

    4. NM_015112.3 → NP_055927.2  microtubule-associated serine/threonine-protein kinase 2 isoform 1

      See identical proteins and their annotated locations for NP_055927.2

      Status: VALIDATED

      Source sequence(s)
      AB047005, AL540100, AL603882, BC065499, CN297081
      Consensus CDS
      CCDS41326.1
      UniProtKB/Swiss-Prot
      O94899, Q5VT07, Q5VT08, Q6P0Q8, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8
      Related
      ENSP00000354671.2, ENST00000361297.7
      Conserved Domains (4) summary
      smart00220
      Location:512 → 785
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:1105 → 1186
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:511 → 790
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:201 → 475
      DUF1908; Domain of unknown function (DUF1908)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      45803612..46036122
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541059.3 → XP_011539361.1  microtubule-associated serine/threonine-protein kinase 2 isoform X1

      Conserved Domains (4) summary
      smart00220
      Location:584 → 857
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:1177 → 1258
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:583 → 862
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:266 → 547
      DUF1908; Domain of unknown function (DUF1908)

    2. XM_011541069.3 → XP_011539371.1  microtubule-associated serine/threonine-protein kinase 2 isoform X24

      Conserved Domains (4) summary
      smart00220
      Location:584 → 857
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:1177 → 1258
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:583 → 862
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:266 → 547
      DUF1908; Domain of unknown function (DUF1908)

    3. XM_011541061.3 → XP_011539363.1  microtubule-associated serine/threonine-protein kinase 2 isoform X2

      Conserved Domains (4) summary
      smart00220
      Location:584 → 857
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:1177 → 1258
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:583 → 862
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:266 → 547
      DUF1908; Domain of unknown function (DUF1908)

    4. XM_047450141.1 → XP_047306097.1  microtubule-associated serine/threonine-protein kinase 2 isoform X25

    5. XM_011541062.3 → XP_011539364.1  microtubule-associated serine/threonine-protein kinase 2 isoform X3

      Conserved Domains (4) summary
      smart00220
      Location:577 → 850
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:1170 → 1251
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:576 → 855
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:266 → 540
      DUF1908; Domain of unknown function (DUF1908)

    6. XM_047450142.1 → XP_047306098.1  microtubule-associated serine/threonine-protein kinase 2 isoform X26

    7. XM_047450096.1 → XP_047306052.1  microtubule-associated serine/threonine-protein kinase 2 isoform X4

    8. XM_047450145.1 → XP_047306101.1  microtubule-associated serine/threonine-protein kinase 2 isoform X27

    9. XM_047450111.1 → XP_047306067.1  microtubule-associated serine/threonine-protein kinase 2 isoform X8

    10. XM_047450149.1 → XP_047306105.1  microtubule-associated serine/threonine-protein kinase 2 isoform X28

    11. XM_047450150.1 → XP_047306106.1  microtubule-associated serine/threonine-protein kinase 2 isoform X29

    12. XM_047450153.1 → XP_047306109.1  microtubule-associated serine/threonine-protein kinase 2 isoform X30

    13. XM_047450105.1 → XP_047306061.1  microtubule-associated serine/threonine-protein kinase 2 isoform X7

    14. XM_047450121.1 → XP_047306077.1  microtubule-associated serine/threonine-protein kinase 2 isoform X10

    15. XM_047450123.1 → XP_047306079.1  microtubule-associated serine/threonine-protein kinase 2 isoform X12

    16. XM_047450129.1 → XP_047306085.1  microtubule-associated serine/threonine-protein kinase 2 isoform X13

    17. XM_011541064.3 → XP_011539366.1  microtubule-associated serine/threonine-protein kinase 2 isoform X6

      Conserved Domains (4) summary
      smart00220
      Location:531 → 804
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:1124 → 1205
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:530 → 809
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:213 → 494
      DUF1908; Domain of unknown function (DUF1908)

    18. XM_047450116.1 → XP_047306072.1  microtubule-associated serine/threonine-protein kinase 2 isoform X9

    19. XM_047450122.1 → XP_047306078.1  microtubule-associated serine/threonine-protein kinase 2 isoform X11

    20. XM_011541063.2 → XP_011539365.1  microtubule-associated serine/threonine-protein kinase 2 isoform X5

      Conserved Domains (4) summary
      smart00220
      Location:534 → 807
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:1127 → 1208
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:533 → 812
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:216 → 497
      DUF1908; Domain of unknown function (DUF1908)

    21. XM_017000752.2 → XP_016856241.1  microtubule-associated serine/threonine-protein kinase 2 isoform X14

    22. XM_017000755.2 → XP_016856244.1  microtubule-associated serine/threonine-protein kinase 2 isoform X19

    23. XM_047450130.1 → XP_047306086.1  microtubule-associated serine/threonine-protein kinase 2 isoform X17

    24. XM_005270655.4 → XP_005270712.1  microtubule-associated serine/threonine-protein kinase 2 isoform X15

      Conserved Domains (4) summary
      smart00220
      Location:434 → 707
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:1027 → 1108
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:433 → 712
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:116 → 397
      DUF1908; Domain of unknown function (DUF1908)

    25. XM_006710477.4 → XP_006710540.1  microtubule-associated serine/threonine-protein kinase 2 isoform X20

      UniProtKB/TrEMBL
      A0A669KBJ4
      Related
      ENSP00000501318.1, ENST00000674079.1
      Conserved Domains (4) summary
      smart00220
      Location:369 → 642
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:962 → 1043
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:368 → 647
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:51 → 332
      DUF1908; Domain of unknown function (DUF1908)

    26. XM_017000753.2 → XP_016856242.1  microtubule-associated serine/threonine-protein kinase 2 isoform X18

    27. XM_047450138.1 → XP_047306094.1  microtubule-associated serine/threonine-protein kinase 2 isoform X23

    28. XM_005270656.6 → XP_005270713.1  microtubule-associated serine/threonine-protein kinase 2 isoform X16

      Conserved Domains (4) summary
      smart00220
      Location:425 → 698
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:1018 → 1099
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:424 → 703
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:107 → 388
      DUF1908; Domain of unknown function (DUF1908)

    29. XM_011541067.3 → XP_011539369.1  microtubule-associated serine/threonine-protein kinase 2 isoform X21

      Conserved Domains (4) summary
      smart00220
      Location:357 → 630
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:950 → 1031
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:356 → 635
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:39 → 320
      DUF1908; Domain of unknown function (DUF1908)

    30. XM_011541068.2 → XP_011539370.1  microtubule-associated serine/threonine-protein kinase 2 isoform X22

      Conserved Domains (4) summary
      smart00220
      Location:350 → 623
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:943 → 1024
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:349 → 628
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:39 → 313
      DUF1908; Domain of unknown function (DUF1908)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      45680810..45913311
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054335330.1 → XP_054191305.1  microtubule-associated serine/threonine-protein kinase 2 isoform X1

    2. XM_054335352.1 → XP_054191327.1  microtubule-associated serine/threonine-protein kinase 2 isoform X24

    3. XM_054335331.1 → XP_054191306.1  microtubule-associated serine/threonine-protein kinase 2 isoform X2

    4. XM_054335353.1 → XP_054191328.1  microtubule-associated serine/threonine-protein kinase 2 isoform X25

    5. XM_054335332.1 → XP_054191307.1  microtubule-associated serine/threonine-protein kinase 2 isoform X3

    6. XM_054335354.1 → XP_054191329.1  microtubule-associated serine/threonine-protein kinase 2 isoform X26

    7. XM_054335333.1 → XP_054191308.1  microtubule-associated serine/threonine-protein kinase 2 isoform X4

    8. XM_054335355.1 → XP_054191330.1  microtubule-associated serine/threonine-protein kinase 2 isoform X27

    9. XM_054335337.1 → XP_054191312.1  microtubule-associated serine/threonine-protein kinase 2 isoform X8

    10. XM_054335356.1 → XP_054191331.1  microtubule-associated serine/threonine-protein kinase 2 isoform X28

    11. XM_054335357.1 → XP_054191332.1  microtubule-associated serine/threonine-protein kinase 2 isoform X29

    12. XM_054335358.1 → XP_054191333.1  microtubule-associated serine/threonine-protein kinase 2 isoform X30

    13. XM_054335336.1 → XP_054191311.1  microtubule-associated serine/threonine-protein kinase 2 isoform X7

    14. XM_054335339.1 → XP_054191314.1  microtubule-associated serine/threonine-protein kinase 2 isoform X10

    15. XM_054335341.1 → XP_054191316.1  microtubule-associated serine/threonine-protein kinase 2 isoform X12

    16. XM_054335342.1 → XP_054191317.1  microtubule-associated serine/threonine-protein kinase 2 isoform X13

    17. XM_054335335.1 → XP_054191310.1  microtubule-associated serine/threonine-protein kinase 2 isoform X6

    18. XM_054335338.1 → XP_054191313.1  microtubule-associated serine/threonine-protein kinase 2 isoform X9

    19. XM_054335340.1 → XP_054191315.1  microtubule-associated serine/threonine-protein kinase 2 isoform X11

    20. XM_054335334.1 → XP_054191309.1  microtubule-associated serine/threonine-protein kinase 2 isoform X5

    21. XM_054335343.1 → XP_054191318.1  microtubule-associated serine/threonine-protein kinase 2 isoform X14

    22. XM_054335348.1 → XP_054191323.1  microtubule-associated serine/threonine-protein kinase 2 isoform X19

    23. XM_054335344.1 → XP_054191319.1  microtubule-associated serine/threonine-protein kinase 2 isoform X15

    24. XM_054335346.1 → XP_054191321.1  microtubule-associated serine/threonine-protein kinase 2 isoform X17

    25. XM_054335349.1 → XP_054191324.1  microtubule-associated serine/threonine-protein kinase 2 isoform X20

    26. XM_054335347.1 → XP_054191322.1  microtubule-associated serine/threonine-protein kinase 2 isoform X18

    27. XM_054335345.1 → XP_054191320.1  microtubule-associated serine/threonine-protein kinase 2 isoform X16

    28. XM_054335350.1 → XP_054191325.1  microtubule-associated serine/threonine-protein kinase 2 isoform X21

    29. XM_054335351.1 → XP_054191326.1  microtubule-associated serine/threonine-protein kinase 2 isoform X22

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P0Q8.2 GenPept UniProtKB/Swiss-Prot:Q6P0Q8

    Gene LinkOut

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