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    Dlgap1 DLG associated protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 224997, updated on 24-Oct-2019

    Summary

    Official Symbol
    Dlgap1provided by MGI
    Official Full Name
    DLG associated protein 1provided by MGI
    Primary source
    MGI:MGI:1346065
    See related
    Ensembl:ENSMUSG00000003279
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gkap; Sapap1; AI845682; AI848168; BB075781; mKIAA4162; 9630002F18; GKAP/SAPAP; GKPA/SAPAP; D17Bwg0511e; 4933422O14Rik
    Expression
    Biased expression in frontal lobe adult (RPKM 40.8), cortex adult (RPKM 32.3) and 6 other tissues See more
    Orthologs

    Genomic context

    See Dlgap1 in Genome Data Viewer
    Location:
    17 E1.3; 17 40.85 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    108 current GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (69969073..70821413)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (70774132..71170753)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 36594 Neighboring gene programmed cell death 2 pseudogene Neighboring gene stathmin 1, related sequence 2 Neighboring gene dephospho-CoA kinase domain containing pseudogene Neighboring gene predicted gene, 46581 Neighboring gene uncharacterized LOC105246307 Neighboring gene predicted gene, 41609 Neighboring gene predicted gene, 41610 Neighboring gene TGFB-induced factor homeobox 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4162

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    structural constituent of postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    aggresome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    chemical synaptic transmission TAS
    Traceable Author Statement
    more info
    PubMed 
    protein localization to synapse ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    signaling IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic density IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density, intracellular component ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    disks large-associated protein 1
    Names
    DAP-1 beta
    PSD-95/SAP90-binding protein 1
    SAP90/PSD-95 associated protein 1
    discs, large homolog-associated protein 1
    guanylate kinase-associated protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128180.1NP_001121652.1  disks large-associated protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC079441, AC154769, AC163902
      Consensus CDS
      CCDS50172.1
      UniProtKB/TrEMBL
      E9QAR5
      Related
      ENSMUSP00000122337.1, ENSMUST00000148486.7
      Conserved Domains (1) summary
      pfam03359
      Location:350682
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    2. NM_001128181.1NP_001121653.1  disks large-associated protein 1 isoform 4

      See identical proteins and their annotated locations for NP_001121653.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) includes alternate exons in the 5' and 3' ends of the coding region but maintains the reading frame, compared to variant 1. It encodes isoform 4 which is shorter and has distinct N- and C-termini, compared to isoform 1.
      Source sequence(s)
      AC079441, AC163902
      Consensus CDS
      CCDS50173.1
      UniProtKB/TrEMBL
      Q3UVU8
      Related
      ENSMUSP00000094890.2, ENSMUST00000097288.3
      Conserved Domains (1) summary
      pfam03359
      Location:352618
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    3. NM_001347411.1NP_001334340.1  disks large-associated protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC079441, AC154604, AC154769, AC163902, AC165424, AI837331
      Consensus CDS
      CCDS84331.1
      UniProtKB/Swiss-Prot
      Q9D415
      Related
      ENSMUSP00000118497.1, ENSMUST00000135938.7
    4. NM_001347412.1NP_001334341.1  disks large-associated protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC079441, AC154604, AC154769, AC163902, AC165424, AI837331
      Consensus CDS
      CCDS84332.1
      UniProtKB/TrEMBL
      Q3UHD8
      Related
      ENSMUSP00000116716.1, ENSMUST00000133983.7
      Conserved Domains (1) summary
      pfam03359
      Location:650982
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    5. NM_001347413.1NP_001334342.1  disks large-associated protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC079441, AC154769, AC163902, AI837331
      Consensus CDS
      CCDS84333.1
      UniProtKB/TrEMBL
      D3Z508
      Related
      ENSMUSP00000117358.1, ENSMUST00000140728.7
    6. NM_001347414.1NP_001334343.1  disks large-associated protein 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC079441, AC154769, AC163902, AI837331
      Consensus CDS
      CCDS84334.1
      UniProtKB/TrEMBL
      D3Z6F4
      Related
      ENSMUSP00000122370.1, ENSMUST00000133717.8
    7. NM_001360665.1NP_001347594.1  disks large-associated protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC079441, AC154604, AC154769, AC163902, AC165424, AC168117
      Consensus CDS
      CCDS84332.1
      Related
      ENSMUSP00000052858.5, ENSMUST00000060072.11
      Conserved Domains (1) summary
      pfam03359
      Location:650982
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    8. NM_027712.3NP_081988.3  disks large-associated protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC154769, BC094369
      UniProtKB/Swiss-Prot
      Q9D415
      Related
      ENSMUSP00000116072.1, ENSMUST00000146730.8
      Conserved Domains (1) summary
      pfam03359
      Location:650916
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    9. NM_177639.6NP_808307.2  disks large-associated protein 1 isoform 1

      See identical proteins and their annotated locations for NP_808307.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC079441, AC154769, AC163902
      Consensus CDS
      CCDS28953.1
      UniProtKB/Swiss-Prot
      Q9D415
      Related
      ENSMUSP00000122896.1, ENSMUST00000155016.7
      Conserved Domains (1) summary
      pfam03359
      Location:660992
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p6 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p6 C57BL/6J

      Range
      69969073..70821413
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524173.3XP_006524236.1  disks large-associated protein 1 isoform X4

      See identical proteins and their annotated locations for XP_006524236.1

      UniProtKB/Swiss-Prot
      Q9D415
      Conserved Domains (1) summary
      pfam03359
      Location:660992
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    2. XM_011246406.3XP_011244708.1  disks large-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011244708.1

      Conserved Domains (1) summary
      pfam03359
      Location:6981030
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    3. XM_011246407.3XP_011244709.1  disks large-associated protein 1 isoform X4

      See identical proteins and their annotated locations for XP_011244709.1

      UniProtKB/Swiss-Prot
      Q9D415
      Conserved Domains (1) summary
      pfam03359
      Location:660992
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    4. XM_006524169.3XP_006524232.1  disks large-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006524232.1

      Conserved Domains (1) summary
      pfam03359
      Location:6981030
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    5. XM_030249738.1XP_030105598.1  disks large-associated protein 1 isoform X4

    6. XM_006524168.3XP_006524231.1  disks large-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006524231.1

      Conserved Domains (1) summary
      pfam03359
      Location:6981030
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    7. XM_006524172.3XP_006524235.1  disks large-associated protein 1 isoform X3

      Conserved Domains (1) summary
      pfam03359
      Location:6701002
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    8. XM_006524171.3XP_006524234.1  disks large-associated protein 1 isoform X2

      Conserved Domains (1) summary
      pfam03359
      Location:6881020
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    9. XM_006524174.3XP_006524237.1  disks large-associated protein 1 isoform X5

      Conserved Domains (1) summary
      pfam03359
      Location:660992
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    10. XM_006524178.4XP_006524241.2  disks large-associated protein 1 isoform X7

      Conserved Domains (1) summary
      pfam03359
      Location:366698
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    11. XM_030249741.1XP_030105601.1  disks large-associated protein 1 isoform X11

    12. XM_030249739.1XP_030105599.1  disks large-associated protein 1 isoform X9

    13. XM_006524183.4XP_006524246.2  disks large-associated protein 1 isoform X13

      Related
      ENSMUSP00000156863.1, ENSMUST00000233283.1
      Conserved Domains (1) summary
      pfam03359
      Location:328660
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    14. XM_006524177.4XP_006524240.2  disks large-associated protein 1 isoform X6

      Conserved Domains (1) summary
      pfam03359
      Location:404736
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    15. XM_006524181.1XP_006524244.1  disks large-associated protein 1 isoform X12

      Conserved Domains (1) summary
      pfam03359
      Location:362694
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    16. XM_006524185.1XP_006524248.1  disks large-associated protein 1 isoform X15

      Conserved Domains (1) summary
      pfam03359
      Location:352684
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    17. XM_017317449.1XP_017172938.1  disks large-associated protein 1 isoform X17

    18. XM_017317450.1XP_017172939.1  disks large-associated protein 1 isoform X18

    19. XM_006524184.3XP_006524247.1  disks large-associated protein 1 isoform X14

      Conserved Domains (1) summary
      pfam03359
      Location:352684
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    20. XM_030249742.1XP_030105602.1  disks large-associated protein 1 isoform X16

    21. XM_006524179.4XP_006524242.1  disks large-associated protein 1 isoform X8

      Conserved Domains (1) summary
      pfam03359
      Location:390722
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    22. XM_006524180.2XP_006524243.2  disks large-associated protein 1 isoform X10

      Conserved Domains (1) summary
      pfam03359
      Location:343675
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
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