Format

Send to:

Choose Destination
    • Showing Current items.

    Washc5 WASH complex subunit 5 [ Mus musculus (house mouse) ]

    Gene ID: 223593, updated on 5-Aug-2018

    Summary

    Official Symbol
    Washc5provided by MGI
    Official Full Name
    WASH complex subunit 5provided by MGI
    Primary source
    MGI:MGI:2146110
    See related
    Ensembl:ENSMUSG00000022350
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C76463; AL022848; strumpellin; E430025E21Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 15.9), kidney adult (RPKM 11.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Washc5 in Genome Data Viewer
    Location:
    15; 15 D1
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (59331997..59374196, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (59163552..59205707, complement)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene zinc finger protein 572 Neighboring gene squalene epoxidase Neighboring gene NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase Neighboring gene predicted gene, 36677

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0196, MGC31278

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    endosomal transport ISO
    Inferred from Sequence Orthology
    more info
     
    oocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    polar body extrusion after meiotic divisions IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    spindle assembly involved in meiosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    WASH complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    WASH complex subunit 5; WASH complex subunit strumpellin

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153548.3NP_705776.2  WASH complex subunit 5

      See identical proteins and their annotated locations for NP_705776.2

      Status: VALIDATED

      Source sequence(s)
      AC113269, BC067035
      Consensus CDS
      CCDS37083.1
      UniProtKB/Swiss-Prot
      Q8C2E7
      Related
      ENSMUSP00000022976.4, ENSMUST00000022976.5
      Conserved Domains (1) summary
      pfam10266
      Location:231103
      Strumpellin; Hereditary spastic paraplegia protein strumpellin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      59331997..59374196 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520759.3XP_006520822.1  WASH complex subunit strumpellin isoform X1

      Conserved Domains (1) summary
      pfam10266
      Location:121004
      Strumpellin; Hereditary spastic paraplegia protein strumpellin
    Support Center