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    OARD1 O-acyl-ADP-ribose deacylase 1 [ Homo sapiens (human) ]

    Gene ID: 221443, updated on 4-Jul-2021

    Summary

    Official Symbol
    OARD1provided by HGNC
    Official Full Name
    O-acyl-ADP-ribose deacylase 1provided by HGNC
    Primary source
    HGNC:HGNC:21257
    See related
    Ensembl:ENSG00000124596 MIM:614393
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TARG1; C6orf130; dJ34B21.3
    Summary
    The protein encoded by this gene is a deacylase that can convert O-acetyl-ADP-ribose to ADP-ribose and acetate, O-propionyl-ADP-ribose to ADP-ribose and propionate, and O-butyryl-ADP-ribose to ADP-ribose and butyrate. The ADP-ribose product is able to inhibit these reactions through a competitive feedback loop. [provided by RefSeq, Jul 2016]
    Expression
    Ubiquitous expression in testis (RPKM 36.5), thyroid (RPKM 20.0) and 25 other tissues See more
    Orthologs
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    Genomic context

    See OARD1 in Genome Data Viewer
    Location:
    6p21.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (41064772..41097787, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (41032511..41065526, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene unc-5 family C-terminal like Neighboring gene translocator protein 2 Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 2 Neighboring gene nuclear transcription factor Y subunit alpha Neighboring gene ADCY10 pseudogene 1 Neighboring gene uncharacterized LOC105375056 Neighboring gene triggering receptor expressed on myeloid cells like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: UNC5CL

    Homology

    Clone Names

    • FLJ17636, MGC19570

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ADP-ribosylglutamate hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables O-acetyl-ADP-ribose deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables purine nucleoside binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in site of DNA damage IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ADP-ribose glycohydrolase OARD1
    Names
    O-acetyl-ADP-ribose deacetylase 1
    O-acetyl-ADP-ribose deacetylase C6orf130
    [Protein ADP-ribosylglutamate] hydrolase OARD1
    terminal ADP-ribose protein glycohydrolase 1
    NP_001316613.1
    NP_001316614.1
    NP_001316615.1
    NP_001316617.1
    NP_001316618.1
    NP_001316619.1
    NP_001316620.1
    NP_001316621.1
    NP_001316622.1
    NP_001316623.1
    NP_001316624.1
    NP_001316625.1
    NP_659500.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001329684.2NP_001316613.1  ADP-ribose glycohydrolase OARD1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1-5 all encode the same isoform (a).
      Source sequence(s)
      AL031778
      Consensus CDS
      CCDS34445.1
      UniProtKB/Swiss-Prot
      Q9Y530
      UniProtKB/TrEMBL
      A0A024RCY9
      Related
      ENSP00000420414.1, ENST00000488238.5
      Conserved Domains (1) summary
      cd02901
      Location:13143
      Macro_Poa1p-like; macrodomain, Poa1p-like family
    2. NM_001329685.1NP_001316614.1  ADP-ribose glycohydrolase OARD1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), along with variants 1, 3, 4, and 5, encodes isoform a.
      Source sequence(s)
      AL031778
      Consensus CDS
      CCDS34445.1
      UniProtKB/Swiss-Prot
      Q9Y530
      UniProtKB/TrEMBL
      A0A024RCY9
      Related
      ENSP00000420193.1, ENST00000463088.5
      Conserved Domains (1) summary
      cd02901
      Location:13143
      Macro_Poa1p-like; macrodomain, Poa1p-like family
    3. NM_001329686.2NP_001316615.1  ADP-ribose glycohydrolase OARD1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), along with variants 1, 2, 4, and 5, encodes isoform a.
      Source sequence(s)
      AL031778
      Consensus CDS
      CCDS34445.1
      UniProtKB/Swiss-Prot
      Q9Y530
      UniProtKB/TrEMBL
      A0A024RCY9
      Related
      ENSP00000416829.2, ENST00000424266.7
      Conserved Domains (1) summary
      cd02901
      Location:13143
      Macro_Poa1p-like; macrodomain, Poa1p-like family
    4. NM_001329688.2NP_001316617.1  ADP-ribose glycohydrolase OARD1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), along with variants 1-4, encodes isoform a.
      Source sequence(s)
      AL031778
      Consensus CDS
      CCDS34445.1
      UniProtKB/Swiss-Prot
      Q9Y530
      UniProtKB/TrEMBL
      A0A024RCY9
      Related
      ENSP00000420601.1, ENST00000468811.5
      Conserved Domains (1) summary
      cd02901
      Location:13143
      Macro_Poa1p-like; macrodomain, Poa1p-like family
    5. NM_001329689.2NP_001316618.1  ADP-ribose glycohydrolase OARD1 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL031778, BC021579, CX758168
      Consensus CDS
      CCDS87395.1
      UniProtKB/TrEMBL
      C9JXC3, Q05CR9
      Related
      ENSP00000419175.1, ENST00000486443.5
      Conserved Domains (1) summary
      cd02901
      Location:1101
      Macro_Poa1p_like; Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...
    6. NM_001329690.2NP_001316619.1  ADP-ribose glycohydrolase OARD1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), along with variants 8-10, encodes isoform c.
      Source sequence(s)
      AL031778
      Consensus CDS
      CCDS87397.1
      UniProtKB/TrEMBL
      C9J5P1
      Related
      ENSP00000418400.1, ENST00000480585.5
      Conserved Domains (1) summary
      cd02901
      Location:1381
      Macro_Poa1p-like; macrodomain, Poa1p-like family
    7. NM_001329691.2NP_001316620.1  ADP-ribose glycohydrolase OARD1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), along with variants 7, 9, and 10, encodes isoform c.
      Source sequence(s)
      AL031778
      Consensus CDS
      CCDS87397.1
      UniProtKB/TrEMBL
      C9J5P1
      Conserved Domains (1) summary
      cd02901
      Location:1381
      Macro_Poa1p-like; macrodomain, Poa1p-like family
    8. NM_001329692.1NP_001316621.1  ADP-ribose glycohydrolase OARD1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), along with variants 7, 8, and 10, encodes isoform c.
      Source sequence(s)
      AL031778, BC021579, DT215423
      Consensus CDS
      CCDS87397.1
      UniProtKB/TrEMBL
      C9J5P1, Q05CR9
      Related
      ENSP00000362247.2, ENST00000373154.6
      Conserved Domains (1) summary
      cd02901
      Location:1381
      Macro_Poa1p-like; macrodomain, Poa1p-like family
    9. NM_001329693.2NP_001316622.1  ADP-ribose glycohydrolase OARD1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), along with variants 7-9, encodes isoform c.
      Source sequence(s)
      AL031778, BC021579, BM353928, DT215423
      Consensus CDS
      CCDS87397.1
      UniProtKB/TrEMBL
      C9J5P1, Q05CR9
      Related
      ENSP00000487484.1, ENST00000628419.2
      Conserved Domains (1) summary
      cd02901
      Location:1381
      Macro_Poa1p-like; macrodomain, Poa1p-like family
    10. NM_001329694.2NP_001316623.1  ADP-ribose glycohydrolase OARD1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), along with variants 12 and 13, encodes isoform d.
      Source sequence(s)
      AL031778
      Consensus CDS
      CCDS87396.1
      UniProtKB/TrEMBL
      C9JA90
      Related
      ENSP00000418098.1, ENST00000482515.5
      Conserved Domains (1) summary
      cl00019
      Location:1361
      Macro_SF; macrodomain superfamily
    11. NM_001329695.1NP_001316624.1  ADP-ribose glycohydrolase OARD1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), along with variants 11 and 13, encodes isoform d.
      Source sequence(s)
      AL031778, BC021579, BE267691, DT215423
      Consensus CDS
      CCDS87396.1
      UniProtKB/TrEMBL
      C9JA90, Q05CR9
      Related
      ENSP00000419875.1, ENST00000464633.5
      Conserved Domains (1) summary
      cl00019
      Location:1361
      Macro_SF; macrodomain superfamily
    12. NM_001329696.2NP_001316625.1  ADP-ribose glycohydrolase OARD1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), along with variants 11 and 12, encodes isoform d.
      Source sequence(s)
      AL031778
      Consensus CDS
      CCDS87396.1
      UniProtKB/TrEMBL
      C9JA90
      Conserved Domains (1) summary
      cl00019
      Location:1361
      Macro_SF; macrodomain superfamily
    13. NM_145063.4NP_659500.1  ADP-ribose glycohydrolase OARD1 isoform a

      See identical proteins and their annotated locations for NP_659500.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), along with variants 1, 2, 3, and 5, encodes isoform a.
      Source sequence(s)
      AL031778, BC011709, BC021579
      Consensus CDS
      CCDS34445.1
      UniProtKB/Swiss-Prot
      Q9Y530
      UniProtKB/TrEMBL
      A0A024RCY9, Q05CR9
      Related
      ENSP00000420484.1, ENST00000479950.5
      Conserved Domains (1) summary
      cd02901
      Location:13143
      Macro_Poa1p-like; macrodomain, Poa1p-like family

    RNA

    1. NR_138080.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      BU740294

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

      Range
      41064772..41097787 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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