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    ADGRF5 adhesion G protein-coupled receptor F5 [ Homo sapiens (human) ]

    Gene ID: 221395, updated on 16-Oct-2021

    Summary

    Official Symbol
    ADGRF5provided by HGNC
    Official Full Name
    adhesion G protein-coupled receptor F5provided by HGNC
    Primary source
    HGNC:HGNC:19030
    See related
    Ensembl:ENSG00000069122
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPR116; KPG_001
    Expression
    Broad expression in lung (RPKM 71.0), fat (RPKM 49.8) and 16 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ADGRF5 in Genome Data Viewer
    Location:
    6p12.3
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (46852522..46954954, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (46820259..46922676, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 66 Neighboring gene meprin A subunit alpha Neighboring gene ADGRF5 antisense RNA 1 Neighboring gene uncharacterized LOC105375080 Neighboring gene adhesion G protein-coupled receptor F1 Neighboring gene Sharpr-MPRA regulatory region 10363

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ90640, KIAA0758, DKFZp564O1923

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in energy reserve metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in erythrocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glomerular filtration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of macrophage activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pharyngeal arch artery morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in surfactant homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in apical part of cell IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    adhesion G protein-coupled receptor F5
    Names
    G-protein coupled receptor 116
    Ig-Hepta homolog
    probable G-protein coupled receptor 116

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098518.2NP_001091988.1  adhesion G protein-coupled receptor F5 precursor

      See identical proteins and their annotated locations for NP_001091988.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AB018301, AL096772, AY140958, AY498875, DB230925
      Consensus CDS
      CCDS4919.1
      UniProtKB/Swiss-Prot
      Q8IZF2
      Related
      ENSP00000283296.7, ENST00000283296.12
      Conserved Domains (6) summary
      smart00408
      Location:285351
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:477562
      IG_like; Immunoglobulin like
      pfam00001
      Location:10301268
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam01390
      Location:170259
      SEA; SEA domain
      pfam01825
      Location:954996
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:10111262
      7tm_4; Olfactory receptor
    2. NM_015234.5NP_056049.4  adhesion G protein-coupled receptor F5 precursor

      See identical proteins and their annotated locations for NP_056049.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AL096772, AY140958, AY498875, DA588699
      Consensus CDS
      CCDS4919.1
      UniProtKB/Swiss-Prot
      Q8IZF2
      Related
      ENSP00000265417.6, ENST00000265417.7
      Conserved Domains (6) summary
      smart00408
      Location:285351
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:477562
      IG_like; Immunoglobulin like
      pfam00001
      Location:10301268
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam01390
      Location:170259
      SEA; SEA domain
      pfam01825
      Location:954996
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:10111262
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

      Range
      46852522..46954954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010421.2XP_016865910.1  adhesion G protein-coupled receptor F5 isoform X5

    2. XM_017010419.2XP_016865908.1  adhesion G protein-coupled receptor F5 isoform X4

      Conserved Domains (6) summary
      smart00408
      Location:285351
      IGc2; Immunoglobulin C-2 Type
      cd15254
      Location:10091283
      7tmB2_GPR116_Ig-Hepta; The immunoglobulin-repeat-containing receptor Ig-hepta/GPR116, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam01390
      Location:170260
      SEA; SEA domain
      pfam01825
      Location:953996
      GPS; GPCR proteolysis site, GPS, motif
      pfam13927
      Location:473546
      Ig_3; Immunoglobulin domain
      cd00096
      Location:289293
      Ig; Ig strand B [structural motif]
    3. XM_017010418.2XP_016865907.1  adhesion G protein-coupled receptor F5 isoform X3

      Conserved Domains (6) summary
      smart00408
      Location:285351
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:517602
      IG_like; Immunoglobulin like
      pfam00001
      Location:10701308
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam01390
      Location:170259
      SEA; SEA domain
      pfam01825
      Location:9941036
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:10511302
      7tm_4; Olfactory receptor
    4. XM_017010420.2XP_016865909.1  adhesion G protein-coupled receptor F5 isoform X5

    5. XM_011514353.3XP_011512655.1  adhesion G protein-coupled receptor F5 isoform X4

      Conserved Domains (6) summary
      smart00408
      Location:285351
      IGc2; Immunoglobulin C-2 Type
      cd15254
      Location:10091283
      7tmB2_GPR116_Ig-Hepta; The immunoglobulin-repeat-containing receptor Ig-hepta/GPR116, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam01390
      Location:170260
      SEA; SEA domain
      pfam01825
      Location:953996
      GPS; GPCR proteolysis site, GPS, motif
      pfam13927
      Location:473546
      Ig_3; Immunoglobulin domain
      cd00096
      Location:289293
      Ig; Ig strand B [structural motif]
    6. XM_005248892.3XP_005248949.1  adhesion G protein-coupled receptor F5 isoform X1

      See identical proteins and their annotated locations for XP_005248949.1

      Conserved Domains (6) summary
      smart00408
      Location:285351
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:517602
      IG_like; Immunoglobulin like
      pfam00001
      Location:10701308
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam01390
      Location:170259
      SEA; SEA domain
      pfam01825
      Location:9941036
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:10511302
      7tm_4; Olfactory receptor
    7. XM_005248895.4XP_005248952.1  adhesion G protein-coupled receptor F5 isoform X3

      Conserved Domains (6) summary
      smart00408
      Location:285351
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:517602
      IG_like; Immunoglobulin like
      pfam00001
      Location:10701308
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam01390
      Location:170259
      SEA; SEA domain
      pfam01825
      Location:9941036
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:10511302
      7tm_4; Olfactory receptor
    8. XM_005248894.4XP_005248951.1  adhesion G protein-coupled receptor F5 isoform X2

      Conserved Domains (6) summary
      smart00408
      Location:285351
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:517602
      IG_like; Immunoglobulin like
      pfam00001
      Location:10701308
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam01390
      Location:170259
      SEA; SEA domain
      pfam01825
      Location:9941036
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:10511302
      7tm_4; Olfactory receptor
    9. XM_017010424.2XP_016865913.1  adhesion G protein-coupled receptor F5 isoform X9

    10. XM_005248893.3XP_005248950.1  adhesion G protein-coupled receptor F5 isoform X1

      See identical proteins and their annotated locations for XP_005248950.1

      Conserved Domains (6) summary
      smart00408
      Location:285351
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:517602
      IG_like; Immunoglobulin like
      pfam00001
      Location:10701308
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam01390
      Location:170259
      SEA; SEA domain
      pfam01825
      Location:9941036
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:10511302
      7tm_4; Olfactory receptor
    11. XM_017010422.2XP_016865911.1  adhesion G protein-coupled receptor F5 isoform X6

    12. XM_017010423.1XP_016865912.1  adhesion G protein-coupled receptor F5 isoform X8

    13. XM_011514354.2XP_011512656.1  adhesion G protein-coupled receptor F5 isoform X7

      Conserved Domains (6) summary
      smart00408
      Location:112178
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:344429
      IG_like; Immunoglobulin like
      pfam00001
      Location:8971135
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam01390
      Location:586
      SEA; SEA domain
      pfam01825
      Location:821863
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:8781129
      7tm_4; Olfactory receptor
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