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    Rasa1 RAS p21 protein activator 1 [ Mus musculus (house mouse) ]

    Gene ID: 218397, updated on 3-Jun-2018
    Official Symbol
    Rasa1provided by MGI
    Official Full Name
    RAS p21 protein activator 1provided by MGI
    Primary source
    MGI:MGI:97860
    See related
    Ensembl:ENSMUSG00000021549 Vega:OTTMUSG00000016336
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gap; Rasa; RasGAP
    Expression
    Ubiquitous expression in CNS E14 (RPKM 8.0), CNS E11.5 (RPKM 7.1) and 28 other tissues See more
    Orthologs
    See Rasa1 in Genome Data Viewer
    Location:
    13 C3; 13 45.05 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (85214699..85289493, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (85354304..85429091, complement)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene smoothened homolog pseudogene Neighboring gene cyclin H Neighboring gene high mobility group box 3 pseudogene Neighboring gene NHP2-like protein 1 pseudogene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC7759

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    ion channel binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
     
    platelet-derived growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase B binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    blood vessel morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to epidermal growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to platelet-derived growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    ras GTPase-activating protein 1
    Names
    GTPase-activating protein
    p120-rasGAP

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145452.3NP_663427.2  ras GTPase-activating protein 1

      Status: VALIDATED

      Source sequence(s)
      BB645489, BC065082, BU055087, CF534745, CV555618
      Consensus CDS
      CCDS26667.2
      UniProtKB/TrEMBL
      E9PYG6
      Related
      ENSMUSP00000105179.2, OTTMUSP00000017544, ENSMUST00000109552.2, OTTMUST00000039255
      Conserved Domains (8) summary
      cd08400
      Location:582707
      C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
      cd10353
      Location:152255
      SH2_Nterm_RasGAP; N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
      cd10354
      Location:341417
      SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
      cd11788
      Location:272330
      SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1
      cd05391
      Location:7051036
      RasGAP_p120GAP; Ras-GTPase Activating Domain of p120
      smart00323
      Location:6891035
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13260
      Location:480567
      PH_RASA1; RAS p21 protein activator (GTPase activating protein) 1 Pleckstrin homology (PH) domain
      pfam00169
      Location:480568
      PH; PH domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      85214699..85289493 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244518.2XP_011242820.1  ras GTPase-activating protein 1 isoform X1

      Conserved Domains (7) summary
      cd08400
      Location:582707
      C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
      cd10353
      Location:152255
      SH2_Nterm_RasGAP; N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
      cd10354
      Location:341417
      SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
      cd11788
      Location:272330
      SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1
      pfam00169
      Location:480568
      PH; PH domain
      cl02569
      Location:705887
      RasGAP; Ras GTPase Activating Domain
      cl17171
      Location:480567
      PH-like; Pleckstrin homology-like domain
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