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    Sh3gl2 SH3-domain GRB2-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 20404, updated on 11-Apr-2018
    Official Symbol
    Sh3gl2provided by MGI
    Official Full Name
    SH3-domain GRB2-like 2provided by MGI
    Primary source
    MGI:MGI:700009
    See related
    Ensembl:ENSMUSG00000028488 Vega:OTTMUSG00000007959
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SH3PA; EEN-B1; Sh3d2a; AI120490; AW555077; 9530001L19Rik; B930049H17Rik
    Expression
    Biased expression in cerebellum adult (RPKM 89.6), frontal lobe adult (RPKM 58.2) and 6 other tissues See more
    Orthologs
    Location:
    4 C4; 4 40.23 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (85205456..85389380)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (84851360..85035284)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene predicted gene 12419 Neighboring gene centlein, centrosomal protein Neighboring gene RAN, member RAS oncogene family pseudogene Neighboring gene phosphoglycerate mutase 1 pseudogene Neighboring gene ADAMTS-like 1 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene predicted gene, 33730

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cellular response to brain-derived neurotrophic factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dendrite extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    lipid tube assembly ISO
    Inferred from Sequence Orthology
    more info
     
    membrane bending ISO
    Inferred from Sequence Orthology
    more info
     
    membrane tubulation ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of membrane tubulation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of clathrin-dependent endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle endocytosis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    synaptic vesicle uncoating IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    vesicle scission ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    basal dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    presynapse ISO
    Inferred from Sequence Orthology
    more info
     
    synapse ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    endophilin-A1
    Names
    SH3 domain protein 2A
    SH3 domain-containing GRB2-like protein 2
    SH3p4
    endophilin I
    endophilin-1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019535.2NP_062408.2  endophilin-A1

      See identical proteins and their annotated locations for NP_062408.2

      Status: PROVISIONAL

      Source sequence(s)
      BC018385
      Consensus CDS
      CCDS18303.1
      UniProtKB/Swiss-Prot
      Q62420
      Related
      ENSMUSP00000030212.8, OTTMUSP00000008291, ENSMUST00000030212.14, OTTMUST00000018054
      Conserved Domains (2) summary
      cd07613
      Location:25247
      BAR_Endophilin_A1; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A1
      cd11803
      Location:293347
      SH3_Endophilin_A; Src homology 3 domain of Endophilin-A

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      85205456..85389380
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537710.2XP_006537773.1  endophilin-A1 isoform X1

      Conserved Domains (2) summary
      cd07613
      Location:1212
      BAR_Endophilin_A1; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A1
      cd11803
      Location:258312
      SH3_Endophilin_A; Src homology 3 domain of Endophilin-A
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