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    ELK4 ETS transcription factor ELK4 [ Homo sapiens (human) ]

    Gene ID: 2005, updated on 12-Aug-2022

    Summary

    Official Symbol
    ELK4provided by HGNC
    Official Full Name
    ETS transcription factor ELK4provided by HGNC
    Primary source
    HGNC:HGNC:3326
    See related
    Ensembl:ENSG00000158711 MIM:600246; AllianceGenome:HGNC:3326
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SAP1
    Summary
    This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in prostate (RPKM 12.4), lymph node (RPKM 7.6) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ELK4 in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (205607943..205632011, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (204872578..204896650, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (205577071..205601139, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904491 Neighboring gene major facilitator superfamily domain containing 4A Neighboring gene Sharpr-MPRA regulatory region 9898 Neighboring gene RNA, U6 small nuclear 418, pseudogene Neighboring gene GABA type A receptor-associated protein pseudogene Neighboring gene solute carrier family 45 member 3 Neighboring gene uncharacterized LOC105371701 Neighboring gene nuclear casein kinase and cyclin dependent kinase substrate 1 Neighboring gene small nucleolar RNA SNORA72

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp434N185

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ETS domain-containing protein Elk-4
    Names
    ELK4, ETS transcription factor
    ELK4, ETS-domain protein (SRF accessory protein 1)
    SAP-1
    serum response factor accessory protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029563.1 RefSeqGene

      Range
      5862..29930
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001973.4NP_001964.2  ETS domain-containing protein Elk-4 isoform a

      See identical proteins and their annotated locations for NP_001964.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (a) encodes the longer isoform (1).
      Source sequence(s)
      AC096533
      Consensus CDS
      CCDS1456.1
      UniProtKB/Swiss-Prot
      P28324, Q6GSJ2
      UniProtKB/TrEMBL
      A0A024R985, A0A024R9C2, Q8IXL1
      Related
      ENSP00000350681.4, ENST00000357992.9
      Conserved Domains (2) summary
      smart00413
      Location:1788
      ETS; erythroblast transformation specific domain
      pfam04929
      Location:237323
      Herpes_DNAp_acc; Herpes DNA replication accessory factor
    2. NM_021795.3NP_068567.1  ETS domain-containing protein Elk-4 isoform b

      See identical proteins and their annotated locations for NP_068567.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (b) uses an alternate splice site in the 3' coding region which results in a frameshift compared to variant 1. This results in a shorter protein (isoform b) which has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC096533
      Consensus CDS
      CCDS1457.1
      UniProtKB/Swiss-Prot
      P28324
      UniProtKB/TrEMBL
      A0A024R997, Q8IXL1
      Related
      ENSP00000289703.4, ENST00000289703.8
      Conserved Domains (2) summary
      smart00413
      Location:1788
      ETS; erythroblast transformation specific domain
      cl26464
      Location:167350
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      205607943..205632011 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      204872578..204896650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)