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    EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 [ Homo sapiens (human) ]

    Gene ID: 1979, updated on 12-May-2019

    Summary

    Official Symbol
    EIF4EBP2provided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 4E binding protein 2provided by HGNC
    Primary source
    HGNC:HGNC:3289
    See related
    Ensembl:ENSG00000148730 MIM:602224
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    4EBP2; PHASII
    Summary
    This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection. [provided by RefSeq, Oct 2008]
    Expression
    Ubiquitous expression in fat (RPKM 50.2), kidney (RPKM 34.8) and 25 other tissues See more
    Orthologs

    Genomic context

    See EIF4EBP2 in Genome Data Viewer
    Location:
    10q22.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (70404105..70428618)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (72163861..72188374)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 20 Neighboring gene centrosomal protein 57 like 1 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 10859 Neighboring gene nodal growth differentiation factor Neighboring gene phosphatase domain containing paladin 1 Neighboring gene YY1 transcription factor pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Longevity regulating pathway - multiple species, organism-specific biosystem (from KEGG)
      Longevity regulating pathway - multiple species, organism-specific biosystemAging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death. Despite the complexity of aging, rec...
    • Longevity regulating pathway - multiple species, conserved biosystem (from KEGG)
      Longevity regulating pathway - multiple species, conserved biosystemAging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death. Despite the complexity of aging, rec...
    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • Translation Factors, organism-specific biosystem (from WikiPathways)
      Translation Factors, organism-specific biosystemProtein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables cells to rapidly manipulate protein production without new mRNA synthesis, ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    eukaryotic initiation factor 4E binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    eukaryotic initiation factor 4E binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    translation repressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    TOR signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cAMP-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    memory ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    modulation of chemical synaptic transmission ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of synaptic plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    social behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    translation TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    postsynapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 4E-binding protein 2
    Names
    4E-BP2
    eIF4E-binding protein 2
    phosphorylated, heat and acid stable regulated by insulin protein II

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004096.5NP_004087.1  eukaryotic translation initiation factor 4E-binding protein 2

      See identical proteins and their annotated locations for NP_004087.1

      Status: REVIEWED

      Source sequence(s)
      AC022532, BC050633, BG717474
      Consensus CDS
      CCDS7303.1
      UniProtKB/Swiss-Prot
      Q13542
      UniProtKB/TrEMBL
      A0A024QZM3
      Related
      ENSP00000362314.4, ENST00000373218.5
      Conserved Domains (1) summary
      pfam05456
      Location:13120
      eIF_4EBP; Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

      Range
      70404105..70428618
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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