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    EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 1978, updated on 10-Oct-2020

    Summary

    Official Symbol
    EIF4EBP1provided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 4E binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:3288
    See related
    Ensembl:ENSG00000187840 MIM:602223
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BP-1; 4EBP1; 4E-BP1; PHAS-I
    Summary
    This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in salivary gland (RPKM 30.3), fat (RPKM 26.3) and 25 other tissues See more
    Orthologs

    Genomic context

    See EIF4EBP1 in Genome Data Viewer
    Location:
    8p11.23
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109.20200815 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (38030534..38060365)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (37888020..37917883)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene glutamic-oxaloacetic transaminase 1 like 1 Neighboring gene adrenoceptor beta 3 Neighboring gene Sharpr-MPRA regulatory region 54 Neighboring gene CRISPRi-validated cis-regulatory element chr8.1253 Neighboring gene ASH2 like, histone lysine methyltransferase complex subunit Neighboring gene RNA, U6 small nuclear 988, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 Gag decreases EIF4EBP1 (4EBP1) associated with the 5' mRNA cap to enhance Gag translation PubMed
    Vpr vpr HIV-1 Vpr expression in HEK293 cells is sufficient to decrease the levels of phosphorylated eIF4E and 4E-BP1 PubMed
    nucleocapsid gag HIV-1 NC downregulates eukaryotic translation initiation factor 4E binding protein 1 in HEK 293T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC4316

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    eukaryotic initiation factor 4E binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    eukaryotic initiation factor 4E binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein phosphatase 2A binding IEA
    Inferred from Electronic Annotation
    more info
     
    translation repressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    IRES-dependent translational initiation of linear mRNA IEA
    Inferred from Electronic Annotation
    more info
     
    TOR signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to dexamethasone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    lung development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of translational initiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to amino acid starvation IEA
    Inferred from Electronic Annotation
    more info
     
    response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    response to ischemia IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 4E-binding protein 1
    Names
    eIF4E-binding protein 1
    phosphorylated heat- and acid-stable protein regulated by insulin 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004095.4NP_004086.1  eukaryotic translation initiation factor 4E-binding protein 1

      See identical proteins and their annotated locations for NP_004086.1

      Status: REVIEWED

      Source sequence(s)
      AB044548, BC004459
      Consensus CDS
      CCDS6100.1
      UniProtKB/Swiss-Prot
      Q13541
      Related
      ENSP00000340691.4, ENST00000338825.5
      Conserved Domains (1) summary
      pfam05456
      Location:11118
      eIF_4EBP; Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      38030534..38060365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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