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    E2F2 E2F transcription factor 2 [ Homo sapiens (human) ]

    Gene ID: 1870, updated on 16-Oct-2021

    Summary

    Official Symbol
    E2F2provided by HGNC
    Official Full Name
    E2F transcription factor 2provided by HGNC
    Primary source
    HGNC:HGNC:3114
    See related
    Ensembl:ENSG00000007968 MIM:600426
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    E2F-2
    Summary
    The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in bone marrow (RPKM 17.6), lymph node (RPKM 3.1) and 8 other tissues See more
    Orthologs
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    Genomic context

    See E2F2 in Genome Data Viewer
    Location:
    1p36.12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (23505696..23531250, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (23832930..23857725, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene transcription elongation factor A3 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 Neighboring gene uncharacterized LOC101928163 Neighboring gene Sharpr-MPRA regulatory region 7496 Neighboring gene uncharacterized LOC105376859

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of RNA polymerase II transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004091.4NP_004082.1  transcription factor E2F2

      See identical proteins and their annotated locations for NP_004082.1

      Status: REVIEWED

      Source sequence(s)
      AF086395, AL021154, L22846
      Consensus CDS
      CCDS236.1
      UniProtKB/Swiss-Prot
      Q14209
      Related
      ENSP00000355249.2, ENST00000361729.3
      Conserved Domains (2) summary
      cd14660
      Location:206306
      E2F_DD; Dimerization domain of E2F transcription factors
      pfam02319
      Location:131194
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      23505696..23531250 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011540870.3XP_011539172.1  transcription factor E2F2 isoform X2

      Conserved Domains (1) summary
      cd14660
      Location:206306
      E2F_DD; Dimerization domain of E2F transcription factors
    2. XM_011540871.2XP_011539173.1  transcription factor E2F2 isoform X4

      See identical proteins and their annotated locations for XP_011539173.1

      Conserved Domains (1) summary
      cd14660
      Location:10110
      E2F_DD; Dimerization domain of E2F transcription factors
    3. XM_011540868.3XP_011539170.1  transcription factor E2F2 isoform X1

      Conserved Domains (2) summary
      cd14660
      Location:204304
      E2F_DD; Dimerization domain of E2F transcription factors
      pfam02319
      Location:131194
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    4. XM_005245749.3XP_005245806.1  transcription factor E2F2 isoform X4

      See identical proteins and their annotated locations for XP_005245806.1

      Conserved Domains (1) summary
      cd14660
      Location:10110
      E2F_DD; Dimerization domain of E2F transcription factors
    5. XM_005245748.3XP_005245805.1  transcription factor E2F2 isoform X3

      Conserved Domains (1) summary
      cd14660
      Location:18118
      E2F_DD; Dimerization domain of E2F transcription factors

    Reference GRCh38.p13 PATCHES

    Genomic

    1. NW_014040926.1 Reference GRCh38.p13 PATCHES

      Range
      276417..301212 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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