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    Phex phosphate regulating endopeptidase homolog, X-linked [ Mus musculus (house mouse) ]

    Gene ID: 18675, updated on 27-Feb-2018
    Official Symbol
    Phexprovided by MGI
    Official Full Name
    phosphate regulating endopeptidase homolog, X-linkedprovided by MGI
    Primary source
    MGI:MGI:107489
    See related
    Ensembl:ENSMUSG00000057457
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gy; Hyp; PEX; HPDR; HPDR1
    Expression
    Biased expression in limb E14.5 (RPKM 1.5), CNS E18 (RPKM 0.2) and 7 other tissues See more
    Orthologs
    See Phex in Genome Data Viewer
    Location:
    X F4; X 72.38 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (157162075..157415286, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (153596618..153853218, complement)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene gem (nuclear organelle) associated protein 8 pseudogene Neighboring gene succinate-Coenzyme A ligase, GDP-forming, beta subunit pseudogene Neighboring gene aldolase B, fructose-bisphosphate pseudogene Neighboring gene mitochondrial import receptor subunit TOM5 homolog Neighboring gene spermine synthase

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    biomineral tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    organophosphate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    metalloendopeptidase homolog PEX
    Names
    Metalloendopeptidase homolog PEX (Phosphate regulating neutral endopeptidase) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein)
    X-linked hypophosphatemia protein
    X-linked phosphate regulating endopeptidase
    phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)
    phosphate regulating neutral endopeptidase
    vitamin D-resistant hypophosphatemic rickets protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011077.2NP_035207.1  metalloendopeptidase homolog PEX

      See identical proteins and their annotated locations for NP_035207.1

      Status: VALIDATED

      Source sequence(s)
      AK158481, CT572987, U49908
      Consensus CDS
      CCDS30497.1
      UniProtKB/Swiss-Prot
      P70669
      UniProtKB/TrEMBL
      Q3TYM9
      Related
      ENSMUSP00000078863.4, ENSMUST00000079945.10
      Conserved Domains (2) summary
      cd08662
      Location:74747
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:67741
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      157162075..157415286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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