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    Klk1b4 kallikrein 1-related pepidase b4 [ Mus musculus (house mouse) ]

    Gene ID: 18048, updated on 31-Jan-2019

    Summary

    Official Symbol
    Klk1b4provided by MGI
    Official Full Name
    kallikrein 1-related pepidase b4provided by MGI
    Primary source
    MGI:MGI:97320
    See related
    Ensembl:ENSMUSG00000066513
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ngfa; mGk-4; alpha-NGF
    Summary
    This gene encodes the alpha subunit of the 7S nerve growth factor (NGF) complex that is essential for the differentiation and survival of distinct populations of neurons in both the central and the peripheral nervous systems. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]
    Expression
    Biased expression in colon adult (RPKM 51.9), kidney adult (RPKM 37.9) and 4 other tissues See more

    Genomic context

    See Klk1b4 in Genome Data Viewer
    Location:
    7 B3; 7 28.72 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (44207433..44211754)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (51462805..51467124)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene kallikrein 1-related peptidase b24 Neighboring gene kallikrein 1-related peptidase b3 Neighboring gene kallikrein 1-related peptidase b5 Neighboring gene predicted gene 10109 Neighboring gene kallikrein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    positive regulation of phosphatidylinositol 3-kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of systemic arterial blood pressure IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    small GTPase mediated signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zymogen activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    kallikrein 1-related peptidase-like b4
    Names
    7S nerve growth factor alpha chain
    7S nerve growth factor alpha subunit

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010915.4NP_035045.2  kallikrein 1-related peptidase-like b4 precursor

      See identical proteins and their annotated locations for NP_035045.2

      Status: REVIEWED

      Source sequence(s)
      AC124176, BF454440
      Consensus CDS
      CCDS21200.1
      UniProtKB/Swiss-Prot
      P00757
      UniProtKB/TrEMBL
      A0A1R3UGK0
      Related
      ENSMUSP00000076576.4, ENSMUST00000077354.4
      Conserved Domains (1) summary
      cd00190
      Location:13251
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      44207433..44211754
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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