Format

Send to:

Choose Destination
    • Showing Current items.

    Myl1 myosin, light polypeptide 1 [ Mus musculus (house mouse) ]

    Gene ID: 17901, updated on 11-Sep-2018

    Summary

    Official Symbol
    Myl1provided by MGI
    Official Full Name
    myosin, light polypeptide 1provided by MGI
    Primary source
    MGI:MGI:97269
    See related
    Ensembl:ENSMUSG00000061816 Vega:OTTMUSG00000026242
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mylf; MLC1f; MLC3f; AI325107
    Summary
    Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two non-phosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in mammary gland adult (RPKM 118.5), limb E14.5 (RPKM 25.3) and 3 other tissues See more
    Orthologs

    Genomic context

    See Myl1 in Genome Data Viewer
    Location:
    1 C3; 1 33.71 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (66924295..66945473, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (66970869..66991630, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene KAT8 regulatory NSL complex subunit 1-like Neighboring gene predicted gene, 39656 Neighboring gene heat shock protein 1 (chaperonin) pseudogene Neighboring gene acyl-Coenzyme A dehydrogenase, long-chain Neighboring gene predicted gene 15793 Neighboring gene ribosomal protein L31, pseudogene 14 Neighboring gene histidyl-tRNA synthetase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    contractile fiber ISO
    Inferred from Sequence Orthology
    more info
     
    myofibril ISO
    Inferred from Sequence Orthology
    more info
     
    myosin complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    myosin light chain 1/3, skeletal muscle isoform
    Names
    A1 catalytic
    A2 catalytic
    MLC1/MLC3
    MLC1F/MLC3F
    myosin light chain A1/A2
    myosin light chain alkali 1/2
    myosin light chain, alkali, fast skeletal muscle
    myosin, light polypeptide 1, alkali; atrial, embryonic
    myosin, light polypeptide 4, alkali; atrial, embryonic

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113387.1NP_001106858.1  myosin light chain 1/3, skeletal muscle isoform isoform 3f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3f) encodes a protein that is 38 aa shorter than isoform 1f. Transcript variants 3f and 1f differ in their first two exons.
      Source sequence(s)
      AK009938, BY785713, W48198
      Consensus CDS
      CCDS48284.1
      UniProtKB/Swiss-Prot
      P05977
      UniProtKB/TrEMBL
      Q545G5
      Related
      ENSMUSP00000112861.1, OTTMUSP00000032323, ENSMUST00000119429.7, OTTMUST00000064973
      Conserved Domains (1) summary
      cl25352
      Location:4149
      EFh_PEF; The penta-EF hand (PEF) family
    2. NM_021285.3NP_067260.1  myosin light chain 1/3, skeletal muscle isoform isoform 1f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1f) encodes a protein that is 38 aa longer than isoform 3f. Transcript variants 1f and 3f differ in their first two exons.
      Source sequence(s)
      AK003182, W48198, W87050
      Consensus CDS
      CCDS15024.1
      UniProtKB/Swiss-Prot
      P05977
      UniProtKB/TrEMBL
      Q545T7
      Related
      ENSMUSP00000027151.5, OTTMUSP00000032275, ENSMUST00000027151.11, OTTMUST00000064902
      Conserved Domains (1) summary
      cl25352
      Location:39187
      EFh_PEF; The penta-EF hand (PEF) family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      66924295..66945473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495763.1XP_006495826.1  myosin light chain 1/3, skeletal muscle isoform isoform X1

      UniProtKB/Swiss-Prot
      P05977
      UniProtKB/TrEMBL
      Q545T7
      Conserved Domains (1) summary
      cl25352
      Location:39187
      EFh_PEF; The penta-EF hand (PEF) family
    2. XM_011238451.2XP_011236753.1  myosin light chain 1/3, skeletal muscle isoform isoform X2

      UniProtKB/TrEMBL
      E9PWG4
      Related
      ENSMUSP00000112880.1, OTTMUSP00000032760, ENSMUST00000120415.7, OTTMUST00000065668
      Conserved Domains (1) summary
      cl08302
      Location:87141
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_187020.1 Reference GRCm38.p4 NOD/MrkTac

      Range
      1336440..1357165 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center