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    mvk-1 MeValonate Kinase [ Caenorhabditis elegans ]

    Gene ID: 175863, updated on 5-Sep-2019

    Summary

    Gene symbol
    mvk-1
    Gene description
    MeValonate Kinase
    Primary source
    WormBase:WBGene00021534
    Locus tag
    CELE_Y42G9A.4
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

    Genomic context

    See mvk-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    13
    Sequence:
    Chromosome: III; NC_003281.10 (6124023..6136276, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene ncRNA Neighboring gene Glycylpeptide N-tetradecanoyltransferase;Probable glycylpeptide N-tetradecanoyltransferase Neighboring gene Serine/threonine-protein kinase SULU Neighboring gene ABC transporter domain-containing protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    • Homologs of the mvk-1 gene: The mvk-1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    mevalonate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    cholesterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    isopentenyl diphosphate biosynthetic process, mevalonate pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    MeValonate Kinase
    NP_001022866.1
    • Product from WormBase gene class mvk;
      Confirmed by transcript evidence
    NP_001022867.1
    • Product from WormBase gene class mvk;
      Confirmed by transcript evidence
    NP_001022868.1
    • Product from WormBase gene class mvk;
      Confirmed by transcript evidence
    NP_001022869.1
    • Product from WormBase gene class mvk;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6124023..6136276 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027698.4NP_001022869.1  MeValonate Kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022869.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q65XY0
      Conserved Domains (4) summary
      PLN02677
      Location:46487
      PLN02677; mevalonate kinase
      pfam00288
      Location:172254
      GHMP_kinases_N; GHMP kinases N terminal domain
      pfam08544
      Location:397456
      GHMP_kinases_C; GHMP kinases C terminal
      pfam15975
      Location:285354
      Flot; Flotillin
    2. NM_001027695.4NP_001022866.1  MeValonate Kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022866.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N4Z7
      Conserved Domains (4) summary
      PLN02677
      Location:46580
      PLN02677; mevalonate kinase
      pfam00288
      Location:265347
      GHMP_kinases_N; GHMP kinases N terminal domain
      pfam08544
      Location:490549
      GHMP_kinases_C; GHMP kinases C terminal
      pfam15975
      Location:378447
      Flot; Flotillin
    3. NM_001027696.6NP_001022867.1  MeValonate Kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022867.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q65XX9
      Conserved Domains (4) summary
      PLN02677
      Location:146587
      PLN02677; mevalonate kinase
      pfam00288
      Location:272354
      GHMP_kinases_N; GHMP kinases N terminal domain
      pfam08544
      Location:497556
      GHMP_kinases_C; GHMP kinases C terminal
      pfam15975
      Location:385454
      Flot; Flotillin
    4. NM_001027697.4NP_001022868.1  MeValonate Kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022868.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q65XX8
      Conserved Domains (4) summary
      PLN02677
      Location:16457
      PLN02677; mevalonate kinase
      pfam00288
      Location:142224
      GHMP_kinases_N; GHMP kinases N terminal domain
      pfam08544
      Location:367426
      GHMP_kinases_C; GHMP kinases C terminal
      pfam15975
      Location:255324
      Flot; Flotillin
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