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    Mgmt O-6-methylguanine-DNA methyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 17314, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mgmtprovided by MGI
    Official Full Name
    O-6-methylguanine-DNA methyltransferaseprovided by MGI
    Primary source
    MGI:MGI:96977
    See related
    Ensembl:ENSMUSG00000054612 AllianceGenome:MGI:96977
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AGT; Agat
    Summary
    Enables methyltransferase activity. Acts upstream of or within DNA alkylation repair and regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to be active in nucleoplasm. Is expressed in embryo and forelimb bud. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endocrine gland cancer (multiple); granulosa cell tumor; high grade glioma (multiple); and retinoblastoma. Orthologous to human MGMT (O-6-methylguanine-DNA methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver adult (RPKM 5.7), subcutaneous fat pad adult (RPKM 5.0) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mgmt in Genome Data Viewer
    Location:
    7 F3; 7 82.07 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (136496315..136732001)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (136894463..137128193)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 6249 Neighboring gene predicted gene, 29978 Neighboring gene STARR-seq mESC enhancer starr_20376 Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_20378 Neighboring gene predicted gene, 39108 Neighboring gene STARR-seq mESC enhancer starr_20380 Neighboring gene STARR-seq mESC enhancer starr_20381 Neighboring gene predicted gene, 30061 Neighboring gene early B cell factor 3 Neighboring gene predicted gene 10578

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (5)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC107020

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables methylated-DNA-[protein]-cysteine S-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables methylated-DNA-[protein]-cysteine S-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables methylated-DNA-[protein]-cysteine S-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    methylated-DNA--protein-cysteine methyltransferase
    Names
    6-O-methylguanine-DNA methyltransferase
    O-6-alkylguanine-DNA alkyltransferase
    O-6-methylguanine-DNA-alkyltransferase
    NP_001363966.1
    NP_001399626.1
    NP_001399627.1
    NP_001399628.1
    NP_001399629.1
    NP_001399630.1
    NP_001399631.1
    NP_001399632.1
    NP_001399633.1
    NP_032624.1
    XP_006507472.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001377037.2NP_001363966.1  methylated-DNA--protein-cysteine methyltransferase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC132594, AC135639, AC148997
      UniProtKB/Swiss-Prot
      P26187, Q54A49
      UniProtKB/TrEMBL
      Q4VA39
      Conserved Domains (1) summary
      COG0350
      Location:6178
      AdaB; O6-methylguanine-DNA--protein-cysteine methyltransferase [Replication, recombination and repair]
    2. NM_001412697.1NP_001399626.1  methylated-DNA--protein-cysteine methyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132594, AC135639, AC148997
      UniProtKB/TrEMBL
      Q4VA39
    3. NM_001412698.1NP_001399627.1  methylated-DNA--protein-cysteine methyltransferase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC132122, AC132594, AC135639, AC148997
      UniProtKB/TrEMBL
      Q4VA39
    4. NM_001412699.1NP_001399628.1  methylated-DNA--protein-cysteine methyltransferase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC132122, AC132594, AC135639, AC148997
      UniProtKB/TrEMBL
      Q4VA39
    5. NM_001412700.1NP_001399629.1  methylated-DNA--protein-cysteine methyltransferase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC132122, AC132594, AC135639, AC148997
      UniProtKB/TrEMBL
      Q4VA39
    6. NM_001412701.1NP_001399630.1  methylated-DNA--protein-cysteine methyltransferase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC132122, AC132594, AC135639, AC148997
    7. NM_001412702.1NP_001399631.1  methylated-DNA--protein-cysteine methyltransferase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC132122, AC132594, AC135639, AC148997
    8. NM_001412703.1NP_001399632.1  methylated-DNA--protein-cysteine methyltransferase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC132122, AC132594, AC135639, AC148997
    9. NM_001412704.1NP_001399633.1  methylated-DNA--protein-cysteine methyltransferase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC132594, AC135639, AC148997
      UniProtKB/Swiss-Prot
      P26187, Q54A49
      UniProtKB/TrEMBL
      Q4VA39
    10. NM_008598.4NP_032624.1  methylated-DNA--protein-cysteine methyltransferase isoform 1

      See identical proteins and their annotated locations for NP_032624.1

      Status: VALIDATED

      Source sequence(s)
      AC132122, AC132594, AC135639, AC148997
      Consensus CDS
      CCDS21945.1
      UniProtKB/Swiss-Prot
      P26187, Q54A49
      UniProtKB/TrEMBL
      Q4VA39
      Related
      ENSMUSP00000080224.3, ENSMUST00000081510.4
      Conserved Domains (1) summary
      COG0350
      Location:6178
      AdaB; O6-methylguanine-DNA--protein-cysteine methyltransferase [Replication, recombination and repair]

    RNA

    1. NR_182026.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC132122, AC132594, AC135639, AC148997
    2. NR_182027.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC132122, AC132594, AC135639, AC148997
    3. NR_182028.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC132122, AC132594, AC135639, AC148997
    4. NR_182029.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC132594, AC135639, AC148997

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      136496315..136732001
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507409.4XP_006507472.1  methylated-DNA--protein-cysteine methyltransferase isoform X4

      See identical proteins and their annotated locations for XP_006507472.1

      UniProtKB/Swiss-Prot
      P26187, Q54A49
      UniProtKB/TrEMBL
      Q4VA39
      Conserved Domains (1) summary
      COG0350
      Location:6178
      AdaB; O6-methylguanine-DNA--protein-cysteine methyltransferase [Replication, recombination and repair]