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    XAGE5 X antigen family member 5 [ Homo sapiens (human) ]

    Gene ID: 170627, updated on 11-Jun-2021

    Summary

    Official Symbol
    XAGE5provided by HGNC
    Official Full Name
    X antigen family member 5provided by HGNC
    Primary source
    HGNC:HGNC:30930
    See related
    Ensembl:ENSG00000171405
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT12.5; GAGED5; XAGE-5
    Summary
    This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See XAGE5 in Genome Data Viewer
    Location:
    Xp11.22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (52811287..52818301)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (52840311..52847325)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene S100A11 pseudogene 8 Neighboring gene SPANX family member N5 Neighboring gene X antigen family member 3-like Neighboring gene eukaryotic translation initiation factor 4A2 pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    General protein information

    Preferred Names
    X antigen family member 5
    Names
    G antigen, family D, 5
    cancer/testis antigen 12.5
    cancer/testis antigen family 12, member 5
    g antigen family D member 5
    protein XAGE-5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001386970.1NP_001373899.1  X antigen family member 5

      Status: VALIDATED

      Source sequence(s)
      AC244505
      Related
      ENSP00000364651.1, ENST00000375501.2
      Conserved Domains (1) summary
      pfam05831
      Location:17102
      GAGE; GAGE protein
    2. NM_130775.3NP_570131.1  X antigen family member 5

      See identical proteins and their annotated locations for NP_570131.1

      Status: VALIDATED

      Source sequence(s)
      AC244505
      Consensus CDS
      CCDS14346.1
      UniProtKB/Swiss-Prot
      Q8WWM1
      UniProtKB/TrEMBL
      Q3SY49
      Related
      ENSP00000342240.1, ENST00000351072.5
      Conserved Domains (1) summary
      pfam05831
      Location:17102
      GAGE; GAGE protein

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

      Range
      52811287..52818301
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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