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    KANK4 KN motif and ankyrin repeat domains 4 [ Homo sapiens (human) ]

    Gene ID: 163782, updated on 11-Jun-2021

    Summary

    Official Symbol
    KANK4provided by HGNC
    Official Full Name
    KN motif and ankyrin repeat domains 4provided by HGNC
    Primary source
    HGNC:HGNC:27263
    See related
    Ensembl:ENSG00000132854 MIM:614612
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ANKRD38; dJ1078M7.1
    Expression
    Biased expression in fat (RPKM 7.4), placenta (RPKM 5.9) and 10 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See KANK4 in Genome Data Viewer
    Location:
    1p31.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (62236165..62319434, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (62701837..62785105, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S15a pseudogene 7 Neighboring gene LINE1 type transposase domain containing 1 Neighboring gene RNA, U6 small nuclear 371, pseudogene Neighboring gene uncharacterized LOC105378768 Neighboring gene ubiquitin specific peptidase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ10884, KIAA0172

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    KN motif and ankyrin repeat domain-containing protein 4
    Names
    ankyrin repeat domain 38
    ankyrin repeat domain-containing protein 38
    kidney ankyrin repeat-containing protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320269.2NP_001307198.1  KN motif and ankyrin repeat domain-containing protein 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The resulting isoform (2) lacks an internal segment and is shorter compared to isoform 1.
      Source sequence(s)
      AK091941, AL139343, AL162739, BU738703, CB989254, CN314410
      Consensus CDS
      CCDS81334.1
      UniProtKB/Swiss-Prot
      Q5T7N3
      Related
      ENSP00000346352.3, ENST00000354381.3
      Conserved Domains (4) summary
      cd00204
      Location:190321
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:200298
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:287342
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:195227
      ANK; ANK repeat [structural motif]
    2. NM_181712.5NP_859063.3  KN motif and ankyrin repeat domain-containing protein 4 isoform 1

      See identical proteins and their annotated locations for NP_859063.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL139343, AL162739, BC060866
      Consensus CDS
      CCDS620.1
      UniProtKB/Swiss-Prot
      Q5T7N3
      Related
      ENSP00000360195.4, ENST00000371153.9
      Conserved Domains (6) summary
      cd00204
      Location:818949
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam06005
      Location:342387
      DUF904; Protein of unknown function (DUF904)
      pfam12075
      Location:2462
      KN_motif; KN motif
      pfam12796
      Location:828926
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:915970
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:823855
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      62236165..62319434 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011540845.3XP_011539147.1  KN motif and ankyrin repeat domain-containing protein 4 isoform X2

      Conserved Domains (6) summary
      cd00204
      Location:818959
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12075
      Location:2462
      KN_motif; KN motif
      pfam12796
      Location:828929
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:905959
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:823869
      ANK; ANK repeat [structural motif]
      cl23720
      Location:341404
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    2. XM_017000483.2XP_016855972.1  KN motif and ankyrin repeat domain-containing protein 4 isoform X3

    3. XM_017000484.2XP_016855973.1  KN motif and ankyrin repeat domain-containing protein 4 isoform X4

      UniProtKB/Swiss-Prot
      Q5T7N3
      Conserved Domains (4) summary
      cd00204
      Location:190321
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:200298
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:287342
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:195227
      ANK; ANK repeat [structural motif]
    4. XM_011540843.3XP_011539145.1  KN motif and ankyrin repeat domain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_011539145.1

      UniProtKB/Swiss-Prot
      Q5T7N3
      Conserved Domains (6) summary
      cd00204
      Location:818949
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam06005
      Location:342387
      DUF904; Protein of unknown function (DUF904)
      pfam12075
      Location:2462
      KN_motif; KN motif
      pfam12796
      Location:828926
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:915970
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:823855
      ANK; ANK repeat [structural motif]
    5. XM_017000485.2XP_016855974.1  KN motif and ankyrin repeat domain-containing protein 4 isoform X5

      UniProtKB/TrEMBL
      B1ALP6
      Related
      ENSP00000360192.1, ENST00000371150.5
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