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    DAB2IP DAB2 interacting protein [ Homo sapiens (human) ]

    Gene ID: 153090, updated on 17-Oct-2021

    Summary

    Official Symbol
    DAB2IPprovided by HGNC
    Official Full Name
    DAB2 interacting proteinprovided by HGNC
    Primary source
    HGNC:HGNC:17294
    See related
    Ensembl:ENSG00000136848 MIM:609205
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AIP1; AIP-1; AF9Q34; DIP1/2
    Summary
    DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005 [PubMed 15386433]).[supplied by OMIM, May 2010]
    Expression
    Ubiquitous expression in colon (RPKM 8.5), testis (RPKM 8.5) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DAB2IP in Genome Data Viewer
    Location:
    9q33.2
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (121566883..121785530)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (124329353..124547809)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987016 Neighboring gene high mobility group box 1 pseudogene 37 Neighboring gene Sharpr-MPRA regulatory region 14365 Neighboring gene uncharacterized LOC105376257 Neighboring gene uncharacterized LOC107987125 Neighboring gene tubulin tyrosine ligase like 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans.
    GeneReviews: Not available
    Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
    GeneReviews: Not available
    Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.
    GeneReviews: Not available
    Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
    GeneReviews: Not available
    Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
    GeneReviews: Not available
    Genome-wide association study of periodontal pathogen colonization.
    GeneReviews: Not available

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ39072, KIAA1743

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 14-3-3 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables SH3 domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT enables Toll-like receptor 4 binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cadherin binding HDA PubMed 
    enables death receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables mitogen-activated protein kinase kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables mitogen-activated protein kinase kinase kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables phosphatidylinositol 3-kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol 3-kinase regulatory subunit binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol-3-phosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol-4-phosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase 2A binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables vascular endothelial growth factor receptor 2 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in I-kappaB phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell motility involved in cerebral cortex radial glia guided migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to epidermal growth factor stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in cellular response to interleukin-1 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to tumor necrosis factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to unfolded protein TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to vascular endothelial growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to vascular endothelial growth factor stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endothelial cell apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in extrinsic apoptotic signaling pathway via death domain receptors IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in layer formation in cerebral cortex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of G0 to G1 transition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of MAP kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of Ras protein signal transduction IC
    Inferred by Curator
    more info
    PubMed 
    involved_in negative regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cellular protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of epithelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of epithelial cell migration TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of epithelial to mesenchymal transition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of epithelial to mesenchymal transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of fibroblast proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of phosphatidylinositol 3-kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of phosphatidylinositol 3-kinase signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of toll-like receptor 4 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of vascular endothelial growth factor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron projection morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of IRE1-mediated unfolded protein response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of JUN kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of dendrite development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of proteasomal protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of synapse maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in reelin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of I-kappaB kinase/NF-kappaB signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of p38MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in tube formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vascular endothelial growth factor receptor-2 signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of AIP1-IRE1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cerebellar mossy fiber ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in climbing fiber ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuronal cell body membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in parallel fiber ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    disabled homolog 2-interacting protein
    Names
    ASK-interacting protein 1
    ASK1-interacting protein 1
    DAB2 interaction protein
    DOC-2/DAB2 interactive protein
    nGAP-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395010.1NP_001381939.1  disabled homolog 2-interacting protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL365274
      Conserved Domains (4) summary
      cd04013
      Location:203342
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:333656
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cd13376
      Location:75261
      PH_DAB2IP; DOC-2/Disabled homolog 2-interacting protein Pleckstrin homology (PH) domain
      pfam12004
      Location:6461150
      DUF3498; Domain of unknown function (DUF3498)
    2. NM_032552.4NP_115941.2  disabled homolog 2-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_115941.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB051530, AL357936, BC037314, BM545676, BM546615
      Consensus CDS
      CCDS6833.2
      UniProtKB/Swiss-Prot
      Q5VWQ8
      Related
      ENSP00000259371.2, ENST00000259371.6
      Conserved Domains (4) summary
      cd04013
      Location:175314
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:305628
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cd13376
      Location:47233
      PH_DAB2IP; DOC-2/Disabled homolog 2-interacting protein Pleckstrin homology (PH) domain
      pfam12004
      Location:6181122
      DUF3498; Domain of unknown function (DUF3498)
    3. NM_138709.2NP_619723.1  disabled homolog 2-interacting protein isoform 2

      See identical proteins and their annotated locations for NP_619723.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon, initiates translation at a downstream start codon and contains a 3' terminal exon that extends past a splice site, compared to variant 1. It encodes isoform 2, which is shorter and has distinct N- and C-termini, compared to isoform 1.
      Source sequence(s)
      AY032952, DA373245
      Consensus CDS
      CCDS6832.1
      UniProtKB/Swiss-Prot
      Q5VWQ8
      Related
      ENSP00000310827.1, ENST00000309989.1
      Conserved Domains (4) summary
      cd04013
      Location:79218
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:209532
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      pfam12004
      Location:5221026
      DUF3498; Domain of unknown function (DUF3498)
      cl17171
      Location:1137
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

      Range
      121566883..121785530
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005251721.1XP_005251778.1  disabled homolog 2-interacting protein isoform X7

      See identical proteins and their annotated locations for XP_005251778.1

      Conserved Domains (6) summary
      cd04013
      Location:175314
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:305628
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:300621
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13376
      Location:47233
      PH_DAB2IP; DOC-2/Disabled homolog 2-interacting protein Pleckstrin homology (PH) domain
      pfam12004
      Location:6181122
      DUF3498; Domain of unknown function (DUF3498)
      cl23720
      Location:10281132
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    2. XM_011518266.2XP_011516568.1  disabled homolog 2-interacting protein isoform X3

      See identical proteins and their annotated locations for XP_011516568.1

      Conserved Domains (5) summary
      cd04013
      Location:196335
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:326649
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:321642
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13376
      Location:68254
      PH_DAB2IP; DOC-2/Disabled homolog 2-interacting protein Pleckstrin homology (PH) domain
      pfam12004
      Location:6391143
      DUF3498; Domain of unknown function (DUF3498)
    3. XM_011518267.2XP_011516569.1  disabled homolog 2-interacting protein isoform X4

      Conserved Domains (5) summary
      cd04013
      Location:196335
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:326649
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:321642
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13376
      Location:68254
      PH_DAB2IP; DOC-2/Disabled homolog 2-interacting protein Pleckstrin homology (PH) domain
      pfam12004
      Location:6391121
      DUF3498; Domain of unknown function (DUF3498)
    4. XM_011518264.3XP_011516566.1  disabled homolog 2-interacting protein isoform X1

      Conserved Domains (6) summary
      cd04013
      Location:196335
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:326649
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:321642
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13376
      Location:68254
      PH_DAB2IP; DOC-2/Disabled homolog 2-interacting protein Pleckstrin homology (PH) domain
      pfam12004
      Location:6391143
      DUF3498; Domain of unknown function (DUF3498)
      cl23720
      Location:10491153
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    5. XM_011518265.3XP_011516567.1  disabled homolog 2-interacting protein isoform X2

      Conserved Domains (6) summary
      cd04013
      Location:196335
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:326649
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:321642
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13376
      Location:68254
      PH_DAB2IP; DOC-2/Disabled homolog 2-interacting protein Pleckstrin homology (PH) domain
      pfam12004
      Location:6391121
      DUF3498; Domain of unknown function (DUF3498)
      cl23720
      Location:10271131
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    6. XM_024447418.1XP_024303186.1  disabled homolog 2-interacting protein isoform X11

      Conserved Domains (4) summary
      cd04013
      Location:139278
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:269592
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cd13376
      Location:11197
      PH_DAB2IP; DOC-2/Disabled homolog 2-interacting protein Pleckstrin homology (PH) domain
      pfam12004
      Location:5821086
      DUF3498; Domain of unknown function (DUF3498)
    7. XM_005251719.4XP_005251776.1  disabled homolog 2-interacting protein isoform X5

      UniProtKB/Swiss-Prot
      Q5VWQ8
      Related
      ENSP00000386183.3, ENST00000408936.7
      Conserved Domains (4) summary
      cd04013
      Location:203342
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:333656
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cd13376
      Location:75261
      PH_DAB2IP; DOC-2/Disabled homolog 2-interacting protein Pleckstrin homology (PH) domain
      pfam12004
      Location:6461150
      DUF3498; Domain of unknown function (DUF3498)
    8. XM_017014300.1XP_016869789.1  disabled homolog 2-interacting protein isoform X10

      UniProtKB/Swiss-Prot
      Q5VWQ8
      Conserved Domains (4) summary
      cd04013
      Location:79218
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:209532
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      pfam12004
      Location:5221026
      DUF3498; Domain of unknown function (DUF3498)
      cl17171
      Location:1137
      PH-like; Pleckstrin homology-like domain
    9. XM_011518271.2XP_011516573.1  disabled homolog 2-interacting protein isoform X10

      See identical proteins and their annotated locations for XP_011516573.1

      UniProtKB/Swiss-Prot
      Q5VWQ8
      Conserved Domains (4) summary
      cd04013
      Location:79218
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:209532
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      pfam12004
      Location:5221026
      DUF3498; Domain of unknown function (DUF3498)
      cl17171
      Location:1137
      PH-like; Pleckstrin homology-like domain
    10. XM_017014299.1XP_016869788.1  disabled homolog 2-interacting protein isoform X8

    11. XM_024447417.1XP_024303185.1  disabled homolog 2-interacting protein isoform X9

      Related
      ENSP00000497706.1, ENST00000648444.1
      Conserved Domains (4) summary
      cd04013
      Location:142281
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:272595
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      pfam12004
      Location:5851089
      DUF3498; Domain of unknown function (DUF3498)
      cl17171
      Location:45200
      PH-like; Pleckstrin homology-like domain
    12. XM_011518270.2XP_011516572.1  disabled homolog 2-interacting protein isoform X10

      See identical proteins and their annotated locations for XP_011516572.1

      UniProtKB/Swiss-Prot
      Q5VWQ8
      Conserved Domains (4) summary
      cd04013
      Location:79218
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:209532
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      pfam12004
      Location:5221026
      DUF3498; Domain of unknown function (DUF3498)
      cl17171
      Location:1137
      PH-like; Pleckstrin homology-like domain
    13. XM_017014298.2XP_016869787.1  disabled homolog 2-interacting protein isoform X6

      Conserved Domains (7) summary
      cd04013
      Location:178317
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:308631
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:303624
      RasGAP; GTPase-activator protein for Ras-like GTPases
      pfam00169
      Location:124177
      PH; PH domain
      pfam12004
      Location:6211125
      DUF3498; Domain of unknown function (DUF3498)
      cl17171
      Location:96236
      PH-like; Pleckstrin homology-like domain
      cl23720
      Location:10311135
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
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