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    CTNNB1 catenin beta 1 [ Homo sapiens (human) ]

    Gene ID: 1499, updated on 19-Sep-2021

    Summary

    Official Symbol
    CTNNB1provided by HGNC
    Official Full Name
    catenin beta 1provided by HGNC
    Primary source
    HGNC:HGNC:2514
    See related
    Ensembl:ENSG00000168036 MIM:116806
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EVR7; CTNNB; MRD19; NEDSDV; armadillo
    Summary
    The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
    Expression
    Ubiquitous expression in placenta (RPKM 94.7), thyroid (RPKM 78.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CTNNB1 in Genome Data Viewer
    Location:
    3p22.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (41199422..41240445)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (41240996..41281934)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10354 Neighboring gene mitochondrial ribosomal protein S31 pseudogene 1 Neighboring gene uncharacterized LOC105377046 Neighboring gene unc-51 like kinase 4 Neighboring gene rRNA-processing protein FCF1 homolog pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Colorectal cancer
    MedGen: C0009402 OMIM: 114500 GeneReviews: Lynch Syndrome
    Compare labs
    Exudative vitreoretinopathy 7
    MedGen: C4539767 OMIM: 617572 GeneReviews: Not available
    Compare labs
    Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
    GeneReviews: Not available
    Hepatocellular carcinoma
    MedGen: C2239176 OMIM: 114550 GeneReviews: Not available
    Compare labs
    Medulloblastoma
    MedGen: C0025149 OMIM: 155255 GeneReviews: Not available
    Compare labs
    Mental retardation, autosomal dominant 19
    MedGen: C3554449 OMIM: 615075 GeneReviews: Not available
    Compare labs
    Neoplasm of ovary
    MedGen: C0919267 OMIM: 167000 GeneReviews: Not available
    Compare labs
    Pilomatrixoma
    MedGen: C0206711 OMIM: 132600 GeneReviews: Not available
    Compare labs
    Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.
    GeneReviews: Not available

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2017-11-22)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2017-11-22)

    ClinGen Genome Curation PagePubMed

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of Beta-catenin (CTNNB1) and transcription factor 4 (TCF4) by siRNA enhances HIV-1 transcription in astrocytes PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of beta-catenin in primary human osteoblasts PubMed
    Nef nef HIV-1 NL4-3, SF2, NA7, and 8161k9 Nef alleles bind to CTNNB1 (b-catenin) in 293T cells and Jurkat T cells PubMed
    nef HIV-1 Nef interacts with beta-catenin by a pull-down assay using purified recombinant proteins. The D186A and F191A mutations in Nef abrogate the binding PubMed
    Tat tat HIV-1 Tat C induces phosphorylation of adherens junction proteins VE-cadherin and beta-catenin in human brain microvascular endothelial cells PubMed
    tat TCF4 and beta-catenin proteins inhibit docking of HIV-1 Tat at the TAR region of the HIV-1 LTR PubMed
    tat HIV-1 Tat-mediated downregulation of beta-catenin/Wnt signaling is dependent on the core and cysteine-rich domains of Tat. Clade C Tat lacks a dicysteine motif (C30C31) and does not downregulate beta-catenin signaling PubMed
    tat HIV-1 Tat and methamphetamine downregulates beta-catenin signaling and also suppresses expression of LEF-1, a key partner of beta-catenin to regulate cognate gene expression PubMed
    tat Axin1 regulates HIV-1 Tat-mediated transcription, which requires beta-catenin and TCF4 PubMed
    Vpu vpu HIV-1 Vpu is a strong competitive inhibitor of beta-TrCP and impairs the degradation of SCF-beta-TrCP substrates such as IKBalpha, ATF4 and beta-catenin PubMed
    vpu HIV-1 Vpu reduces the beta-catenin interaction with E-cadherin and the Vpu-mediated dissociation of beta-catenin with E-cadherin enhances particle release PubMed
    vpu HIV-1 Vpu S61A mutant efficiently interacts with endogenous betaTrCP and strongly stabilizes beta-catenin PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1) at amino acid residues 46-47 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ25606, FLJ37923, DKFZp686D02253

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables I-SMAD binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables SMAD binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables alpha-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables alpha-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables cadherin binding HDA PubMed 
    enables cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cadherin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables disordered domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables estrogen receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables histone methyltransferase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nuclear receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nuclear receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein phosphatase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables transcription coregulator binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription factor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in T cell differentiation in thymus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adherens junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in anterior/posterior axis specification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in astrocyte-dopaminergic neuron signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bone resorption IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in branching involved in blood vessel morphogenesis IC
    Inferred by Curator
    more info
    PubMed 
    involved_in branching involved in ureteric bud morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation IC
    Inferred by Curator
    more info
     
    involved_in canonical Wnt signaling pathway involved in negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell fate specification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell maturation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell morphogenesis involved in differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to indole-3-methanol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in central nervous system vasculogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cranial ganglion development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cranial skeletal system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in detection of muscle stretch TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in dorsal root ganglion development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dorsal/ventral axis specification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ectoderm development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic axis specification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic brain development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic digit morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic foregut morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic forelimb morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic heart tube development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic hindlimb morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic skeletal limb joint morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endodermal cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endothelial tube morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in epithelial cell differentiation involved in prostate gland development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epithelial to mesenchymal transition TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in epithelial tube branching involved in lung morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fungiform papilla formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gastrulation with mouth forming second IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in genitalia morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glial cell fate determination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hair cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in hair follicle morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hair follicle placode formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hindbrain development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in layer formation in cerebral cortex IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lens morphogenesis in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lung cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lung induction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lung-associated mesenchyme development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in male genitalia development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mesenchymal cell proliferation involved in lung development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in metanephros morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in midbrain dopaminergic neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of chondrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of mitotic cell cycle, embryonic ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of oligodendrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of osteoclast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of oxidative stress-induced neuron death IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein sumoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nephron tubule formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neural plate development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron projection extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in odontogenesis of dentin-containing tooth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in oocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in osteoclast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in oviduct development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pancreas development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of branching involved in lung morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of core promoter binding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of determination of dorsal identity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of endothelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of epithelial cell proliferation involved in prostate gland development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of epithelial to mesenchymal transition IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of heparan sulfate proteoglycan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of histone H3-K4 methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of mesenchymal cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuroblast proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of skeletal muscle tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of positive regulation of telomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of positive regulation of telomere maintenance via telomerase ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of transcription elongation from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein localization to cell surface IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proximal/distal pattern formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of angiogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of calcium ion import IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of centriole-centriole cohesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of centromeric sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of fibroblast proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of myelination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of nephron tubule epithelial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of neurogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of protein localization to cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of secondary heart field cardioblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of timing of anagen IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in renal inner medulla development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in renal outer medulla development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in renal vesicle formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to estradiol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in smooth muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in stem cell population maintenance TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in sympathetic ganglion development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in synapse organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptic vesicle clustering IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptic vesicle transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in thymus development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in trachea formation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    part_of Scrib-APC-beta-catenin complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of Wnt signalosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical part of cell IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apicolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of beta-catenin destruction complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of beta-catenin-TCF complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of beta-catenin-TCF complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of beta-catenin-TCF7L2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    part_of catenin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of catenin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell junction TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in euchromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in fascia adherens IEA
    Inferred from Electronic Annotation
    more info
     
    part_of flotillin complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in focal adhesion HDA PubMed 
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in microvillus membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density, intracellular component IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in presynaptic active zone cytoplasmic component IEA
    Inferred from Electronic Annotation
    more info
     
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-DNA complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    catenin beta-1
    Names
    catenin (cadherin-associated protein), beta 1, 88kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013302.2 RefSeqGene

      Range
      5055..45993
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1108

    mRNA and Protein(s)

    1. NM_001098209.2NP_001091679.1  catenin beta-1 isoform 1

      See identical proteins and their annotated locations for NP_001091679.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC104307, X87838
      Consensus CDS
      CCDS2694.1
      UniProtKB/Swiss-Prot
      P35222
      UniProtKB/TrEMBL
      A0A024R2Q3
      Related
      ENSP00000379488.3, ENST00000396185.8
      Conserved Domains (4) summary
      smart00185
      Location:350390
      ARM; Armadillo/beta-catenin-like repeats
      COG5064
      Location:142431
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:402427
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:583622
      Arm; Armadillo/beta-catenin-like repeat
    2. NM_001098210.2NP_001091680.1  catenin beta-1 isoform 1

      See identical proteins and their annotated locations for NP_001091680.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC104307, DA216720, Z19054
      Consensus CDS
      CCDS2694.1
      UniProtKB/Swiss-Prot
      P35222
      UniProtKB/TrEMBL
      A0A024R2Q3
      Related
      ENSP00000379486.3, ENST00000396183.7
      Conserved Domains (4) summary
      smart00185
      Location:350390
      ARM; Armadillo/beta-catenin-like repeats
      COG5064
      Location:142431
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:402427
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:583622
      Arm; Armadillo/beta-catenin-like repeat
    3. NM_001330729.2NP_001317658.1  catenin beta-1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' and 3' UTRs and the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC104307, AK294778, CA944934
      Consensus CDS
      CCDS87067.1
      UniProtKB/TrEMBL
      B4DGU4
      Related
      ENSP00000411226.1, ENST00000453024.6
      Conserved Domains (4) summary
      smart00185
      Location:343383
      ARM; Armadillo/beta-catenin-like repeats
      COG5064
      Location:135424
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:395420
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:576615
      Arm; Armadillo/beta-catenin-like repeat
    4. NM_001904.4NP_001895.1  catenin beta-1 isoform 1

      See identical proteins and their annotated locations for NP_001895.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC104307, X87838
      Consensus CDS
      CCDS2694.1
      UniProtKB/Swiss-Prot
      P35222
      UniProtKB/TrEMBL
      A0A024R2Q3
      Related
      ENSP00000344456.5, ENST00000349496.11
      Conserved Domains (4) summary
      smart00185
      Location:350390
      ARM; Armadillo/beta-catenin-like repeats
      COG5064
      Location:142431
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:402427
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:583622
      Arm; Armadillo/beta-catenin-like repeat

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      41199422..41240445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006712983.2XP_006713046.1  catenin beta-1 isoform X2

      See identical proteins and their annotated locations for XP_006713046.1

      UniProtKB/TrEMBL
      B4DGU4
      Related
      ENSP00000495794.1, ENST00000644678.1
      Conserved Domains (4) summary
      smart00185
      Location:343383
      ARM; Armadillo/beta-catenin-like repeats
      COG5064
      Location:135424
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:395420
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:576615
      Arm; Armadillo/beta-catenin-like repeat
    2. XM_024453360.1XP_024309128.1  catenin beta-1 isoform X2

      Related
      ENSP00000495426.1, ENST00000646116.1
      Conserved Domains (4) summary
      smart00185
      Location:343383
      ARM; Armadillo/beta-catenin-like repeats
      COG5064
      Location:135424
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:395420
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:576615
      Arm; Armadillo/beta-catenin-like repeat
    3. XM_006712985.1XP_006713048.1  catenin beta-1 isoform X3

      Related
      ENSP00000496649.1, ENST00000644138.1
      Conserved Domains (3) summary
      smart00185
      Location:350390
      ARM; Armadillo/beta-catenin-like repeats
      cd00020
      Location:399518
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:402427
      ARM; armadillo repeat [structural motif]
    4. XM_024453356.1XP_024309124.1  catenin beta-1 isoform X1

      Related
      ENSP00000494053.1, ENST00000643977.1
      Conserved Domains (4) summary
      smart00185
      Location:350390
      ARM; Armadillo/beta-catenin-like repeats
      COG5064
      Location:142431
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:402427
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:583622
      Arm; Armadillo/beta-catenin-like repeat
    5. XM_024453358.1XP_024309126.1  catenin beta-1 isoform X1

      Related
      ENSP00000494914.1, ENST00000646369.1
      Conserved Domains (4) summary
      smart00185
      Location:350390
      ARM; Armadillo/beta-catenin-like repeats
      COG5064
      Location:142431
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:402427
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:583622
      Arm; Armadillo/beta-catenin-like repeat
    6. XM_024453359.1XP_024309127.1  catenin beta-1 isoform X2

      Related
      ENSP00000494780.1, ENST00000644524.1
      Conserved Domains (4) summary
      smart00185
      Location:343383
      ARM; Armadillo/beta-catenin-like repeats
      COG5064
      Location:135424
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:395420
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:576615
      Arm; Armadillo/beta-catenin-like repeat
    7. XM_017005738.1XP_016861227.1  catenin beta-1 isoform X1

      UniProtKB/Swiss-Prot
      P35222
      UniProtKB/TrEMBL
      A0A024R2Q3
      Related
      ENSP00000409302.2, ENST00000450969.6
      Conserved Domains (4) summary
      smart00185
      Location:350390
      ARM; Armadillo/beta-catenin-like repeats
      COG5064
      Location:142431
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:402427
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:583622
      Arm; Armadillo/beta-catenin-like repeat
    8. XM_024453357.1XP_024309125.1  catenin beta-1 isoform X1

      Related
      ENSP00000495076.1, ENST00000642315.1
      Conserved Domains (4) summary
      smart00185
      Location:350390
      ARM; Armadillo/beta-catenin-like repeats
      COG5064
      Location:142431
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:402427
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:583622
      Arm; Armadillo/beta-catenin-like repeat
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