Format

Send to:

Choose Destination
    • Showing Current items.

    CST1 cystatin SN [ Homo sapiens (human) ]

    Gene ID: 1469, updated on 21-Apr-2019

    Summary

    Official Symbol
    CST1provided by HGNC
    Official Full Name
    cystatin SNprovided by HGNC
    Primary source
    HGNC:HGNC:2473
    See related
    Ensembl:ENSG00000170373 MIM:123855
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a cysteine proteinase inhibitor found in saliva, tears, urine, and seminal fluid. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward salivary gland (RPKM 7300.7) See more

    Genomic context

    See CST1 in Genome Data Viewer
    Location:
    20p11.21
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (23747553..23750937, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (23728190..23731574, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene cystatin S Neighboring gene uncharacterized LOC105372574 Neighboring gene cystatin pseudogene 2 Neighboring gene uncharacterized LOC107985432

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Salivary secretion, organism-specific biosystem (from KEGG)
      Salivary secretion, organism-specific biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
    • Salivary secretion, conserved biosystem (from KEGG)
      Salivary secretion, conserved biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    cystatin-SN
    Names
    cystain-SA-I
    cystatin 1
    cystatin SA-I
    cysteine proteinase inhibitor, type 2 family
    salivary cystatin-SA-1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001898.2NP_001889.2  cystatin-SN precursor

      See identical proteins and their annotated locations for NP_001889.2

      Status: REVIEWED

      Source sequence(s)
      BC021225
      Consensus CDS
      CCDS13160.1
      UniProtKB/Swiss-Prot
      P01037
      Related
      ENSP00000305731.2, ENST00000304749.6
      Conserved Domains (1) summary
      smart00043
      Location:30139
      CY; Cystatin-like domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

      Range
      23747553..23750937 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center