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    Ebf2 early B cell factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 13592, updated on 2-Oct-2018

    Summary

    Official Symbol
    Ebf2provided by MGI
    Official Full Name
    early B cell factor 2provided by MGI
    Primary source
    MGI:MGI:894332
    See related
    Ensembl:ENSMUSG00000022053 Vega:OTTMUSG00000040034
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    OE-3; EBF-2; Mmot1; O/E-3; D14Ggc1e
    Expression
    Biased expression in limb E14.5 (RPKM 7.4), CNS E11.5 (RPKM 7.0) and 10 other tissues See more
    Orthologs

    Genomic context

    See Ebf2 in Genome Data Viewer
    Location:
    14; 14 D1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (67233292..67430952)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (67852129..68048604)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30806 Neighboring gene predicted gene 20675 Neighboring gene RIKEN cDNA 4930438E09 gene Neighboring gene predicted gene 6878 Neighboring gene predicted gene 10860 Neighboring gene predicted gene, 38409 Neighboring gene cell division cycle associated 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription factor COE2
    Names
    MET-mesencephalon-olfactory TF1
    MET-mesencephalon-olfactory transcription factor 1
    Olf-1/EBF-like 3
    metencephalon-mesencephalon-olfactory transcription factor 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276387.1NP_001263316.1  transcription factor COE2

      See identical proteins and their annotated locations for NP_001263316.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK053013, AK139262, BB669324, CT010493
      Consensus CDS
      CCDS27228.1
      UniProtKB/Swiss-Prot
      O08792
      Related
      ENSMUSP00000135500.1, OTTMUSP00000058130, ENSMUST00000176161.7, OTTMUST00000103955
      Conserved Domains (3) summary
      cd01175
      Location:253337
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:20246
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:338381
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain
    2. NM_001360202.1NP_001347131.1  transcription factor COE2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      BC050922, BM932499, CT010493
      Conserved Domains (3) summary
      cd01175
      Location:253337
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:20246
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:338381
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain
    3. NM_010095.6NP_034225.1  transcription factor COE2

      See identical proteins and their annotated locations for NP_034225.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK053013, AK139262, BB669324, CT010493
      Consensus CDS
      CCDS27228.1
      UniProtKB/Swiss-Prot
      O08792
      Related
      ENSMUSP00000022637.7, OTTMUSP00000058129, ENSMUST00000022637.13, OTTMUST00000103954
      Conserved Domains (3) summary
      cd01175
      Location:253337
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:20246
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:338381
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      67233292..67430952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244945.2XP_011243247.1  transcription factor COE2 isoform X1

      UniProtKB/Swiss-Prot
      O08792
      Related
      ENSMUSP00000135782.1, OTTMUSP00000058131, ENSMUST00000176029.1, OTTMUST00000103957
      Conserved Domains (3) summary
      cd01175
      Location:253337
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:20246
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:338381
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain
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