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    H1-8 H1.8 linker histone [ Homo sapiens (human) ]

    Gene ID: 132243, updated on 5-Sep-2021

    Summary

    Official Symbol
    H1-8provided by HGNC
    Official Full Name
    H1.8 linker histoneprovided by HGNC
    Primary source
    HGNC:HGNC:18463
    See related
    Ensembl:ENSG00000178804
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H1.8; H1oo; osH1; H1FOO
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a replication-independent histone that is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The related mouse gene is expressed only in oocytes. [provided by RefSeq, Oct 2015]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See H1-8 in Genome Data Viewer
    Location:
    3q22.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (129543175..129555185)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (129262018..129270310)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene rhodopsin enhancer region Neighboring gene rhodopsin Neighboring gene Sharpr-MPRA regulatory region 1469 Neighboring gene plexin D1 Neighboring gene RNA, 7SL, cytoplasmic 752, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC50807

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nucleosomal DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nucleosomal DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of stem cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nucleosome positioning IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nucleosome positioning ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of DNA methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    NOT located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    histone H1.8
    Names
    H1 histone family member O oocyte specific
    histone H1oo
    oocyte-specific histone H1
    oocyte-specific linker histone H1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308262.2NP_001295191.1  histone H1.8 isoform 2

      See identical proteins and their annotated locations for NP_001295191.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two 5' exons and contains an alternate 5' terminal exon, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      BC047943, BM564157
      Consensus CDS
      CCDS77815.1
      UniProtKB/Swiss-Prot
      Q8IZA3
      Related
      ENSP00000422964.1, ENST00000503977.1
      Conserved Domains (1) summary
      PRK12373
      Location:793
      PRK12373; NADH dehydrogenase subunit E; Provisional
    2. NM_153833.3NP_722575.1  histone H1.8 isoform 1

      See identical proteins and their annotated locations for NP_722575.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC080007
      Consensus CDS
      CCDS3064.1
      UniProtKB/Swiss-Prot
      Q8IZA3
      Related
      ENSP00000319799.2, ENST00000324382.7
      Conserved Domains (1) summary
      cd00073
      Location:49139
      H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      129543175..129555185
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017005733.1XP_016861222.1  histone H1.8 isoform X1

      UniProtKB/Swiss-Prot
      Q8IZA3
      Conserved Domains (1) summary
      PRK12373
      Location:793
      PRK12373; NADH dehydrogenase subunit E; Provisional
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