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    CMTM3 CKLF like MARVEL transmembrane domain containing 3 [ Homo sapiens (human) ]

    Gene ID: 123920, updated on 22-Sep-2022

    Summary

    Official Symbol
    CMTM3provided by HGNC
    Official Full Name
    CKLF like MARVEL transmembrane domain containing 3provided by HGNC
    Primary source
    HGNC:HGNC:19174
    See related
    Ensembl:ENSG00000140931 MIM:607886; AllianceGenome:HGNC:19174
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BNAS2; CKLFSF3
    Summary
    This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants containing different 5' UTRs, but encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 24.7), placenta (RPKM 16.7) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CMTM3 in Genome Data Viewer
    Location:
    16q22.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (66603996..66613892)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (72398291..72408187)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (66637899..66647795)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene CKLF-CMTM1 readthrough Neighboring gene CKLF like MARVEL transmembrane domain containing 1 Neighboring gene CKLF like MARVEL transmembrane domain containing 2 Neighboring gene CKLF like MARVEL transmembrane domain containing 4 Neighboring gene Sharpr-MPRA regulatory region 8452 Neighboring gene dynein cytoplasmic 1 light intermediate chain 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ31762, MGC51956

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in blastocyst hatching IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of B cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    CKLF-like MARVEL transmembrane domain-containing protein 3
    Names
    chemokine-like factor superfamily member 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363918.2NP_001350847.1  CKLF-like MARVEL transmembrane domain-containing protein 3

      Status: REVIEWED

      Source sequence(s)
      AC018557
      Consensus CDS
      CCDS10815.1
      UniProtKB/Swiss-Prot
      Q8IZ59
      UniProtKB/TrEMBL
      A0A024R6Y8
      Conserved Domains (1) summary
      pfam01284
      Location:36149
      MARVEL; Membrane-associating domain
    2. NM_001363923.2NP_001350852.1  CKLF-like MARVEL transmembrane domain-containing protein 3

      Status: REVIEWED

      Source sequence(s)
      AC018557, AF479813, AK056324
      UniProtKB/Swiss-Prot
      Q8IZ59
      UniProtKB/TrEMBL
      A0A024R6Y8
      Related
      ENSP00000400482.2, ENST00000424011.6
      Conserved Domains (1) summary
      pfam01284
      Location:36149
      MARVEL; Membrane-associating domain
    3. NM_144601.5NP_653202.1  CKLF-like MARVEL transmembrane domain-containing protein 3

      See identical proteins and their annotated locations for NP_653202.1

      Status: REVIEWED

      Source sequence(s)
      AC018557, AF479813
      Consensus CDS
      CCDS10815.1
      UniProtKB/Swiss-Prot
      Q8IZ59, Q96MX0
      UniProtKB/TrEMBL
      A0A024R6Y8
      Related
      ENSP00000354579.4, ENST00000361909.8
      Conserved Domains (1) summary
      pfam01284
      Location:36149
      MARVEL; Membrane-associating domain
    4. NM_181553.4NP_853531.1  CKLF-like MARVEL transmembrane domain-containing protein 3

      See identical proteins and their annotated locations for NP_853531.1

      Status: REVIEWED

      Source sequence(s)
      AF479813, BC047701
      Consensus CDS
      CCDS10815.1
      UniProtKB/Swiss-Prot
      Q8IZ59, Q96MX0
      UniProtKB/TrEMBL
      A0A024R6Y8
      Related
      ENSP00000455851.1, ENST00000567572.6
      Conserved Domains (1) summary
      pfam01284
      Location:36149
      MARVEL; Membrane-associating domain

    RNA

    1. NR_037619.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018557, AF479813, CT001840

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      66603996..66613892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047433594.1XP_047289550.1  CKLF-like MARVEL transmembrane domain-containing protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q8IZ59
      UniProtKB/TrEMBL
      A0A024R6Y8
      Related
      ENSP00000455758.1, ENST00000562707.5
    2. XM_047433597.1XP_047289553.1  CKLF-like MARVEL transmembrane domain-containing protein 3 isoform X3

      UniProtKB/TrEMBL
      H3BUD5
      Related
      ENSP00000457589.1, ENST00000564060.5
    3. XM_047433595.1XP_047289551.1  CKLF-like MARVEL transmembrane domain-containing protein 3 isoform X2

      UniProtKB/TrEMBL
      J3KSR6
      Related
      ENSP00000462613.1, ENST00000566756.5
    4. XM_047433598.1XP_047289554.1  CKLF-like MARVEL transmembrane domain-containing protein 3 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      72398291..72408187
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001048251.1: Suppressed sequence

      Description
      NM_001048251.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    2. NM_181554.1: Suppressed sequence

      Description
      NM_181554.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    3. NM_181555.1: Suppressed sequence

      Description
      NM_181555.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript variant.