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    Park7 Parkinsonism associated deglycase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117287, updated on 19-Aug-2018

    Summary

    Official Symbol
    Park7provided by RGD
    Official Full Name
    Parkinsonism associated deglycaseprovided by RGD
    Primary source
    RGD:621808
    See related
    Ensembl:ENSRNOG00000018289
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dj1; CAP1; DJ-1; SP22
    Summary
    displays a specific localization pattern to the anterior-ventral surface of the equatorial segment; may play a role in sperm-egg interactions and fertilization [RGD, Feb 2006]
    Expression
    Biased expression in Muscle (RPKM 779.6), Kidney (RPKM 488.1) and 9 other tissues See more
    Orthologs

    Genomic context

    See Park7 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (167982438..168004724, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 5 NC_005104.3 (171559202..171582476, complement)

    Chromosome 5 - NC_005104.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556220 Neighboring gene ERBB receptor feedback inhibitor 1 Neighboring gene uncharacterized LOC102556316 Neighboring gene TNF receptor superfamily member 9 Neighboring gene uncharacterized LOC102556501

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Parkinson's disease, organism-specific biosystem (from KEGG)
      Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Mutations...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    L-dopa decarboxylase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    L-dopa decarboxylase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    L-dopa decarboxylase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    androgen receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    androgen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    androgen receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    copper ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    copper ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cupric ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    cupric ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    cupric ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cuprous ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    cuprous ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    cuprous ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytokine binding IEA
    Inferred from Electronic Annotation
    more info
     
    cytokine binding ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mercury ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    mercury ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    mercury ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    oxidoreductase activity, acting on peroxide as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on peroxide as acceptor ISO
    Inferred from Sequence Orthology
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    peroxiredoxin activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein deglycase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein deglycase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein deglycase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    repressing transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    repressing transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    repressing transcription factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    scaffold protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    scaffold protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    signaling receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    small protein activating enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    small protein activating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    small protein activating enzyme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    superoxide dismutase copper chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    superoxide dismutase copper chaperone activity ISO
    Inferred from Sequence Orthology
    more info
     
    superoxide dismutase copper chaperone activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    tyrosine 3-monooxygenase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    tyrosine 3-monooxygenase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    tyrosine 3-monooxygenase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ubiquitin-like protein conjugating enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-like protein conjugating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-like protein conjugating enzyme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ubiquitin-specific protease binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-specific protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    adult locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to glyoxal IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to glyoxal ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to glyoxal ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to hydrogen peroxide ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
     
    detoxification of copper ion IEA
    Inferred from Electronic Annotation
    more info
     
    detoxification of copper ion ISO
    Inferred from Sequence Orthology
    more info
     
    detoxification of copper ion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    detoxification of mercury ion IEA
    Inferred from Electronic Annotation
    more info
     
    detoxification of mercury ion ISO
    Inferred from Sequence Orthology
    more info
     
    detoxification of mercury ion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dopamine uptake involved in synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme active site formation via L-cysteine sulfinic acid ISO
    Inferred from Sequence Orthology
    more info
     
    fertilization TAS
    Traceable Author Statement
    more info
    PubMed 
    glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    glutathione deglycation IEA
    Inferred from Electronic Annotation
    more info
     
    glutathione deglycation ISO
    Inferred from Sequence Orthology
    more info
     
    glycolate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    glycolate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    glyoxal metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    guanine deglycation ISO
    Inferred from Sequence Orthology
    more info
     
    guanine deglycation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    guanine deglycation, glyoxal removal IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    guanine deglycation, glyoxal removal IEA
    Inferred from Electronic Annotation
    more info
     
    guanine deglycation, glyoxal removal ISO
    Inferred from Sequence Orthology
    more info
     
    guanine deglycation, glyoxal removal ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    guanine deglycation, methylglyoxal removal IEA
    Inferred from Electronic Annotation
    more info
     
    guanine deglycation, methylglyoxal removal ISO
    Inferred from Sequence Orthology
    more info
     
    guanine deglycation, methylglyoxal removal ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    hydrogen peroxide metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    hydrogen peroxide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    hydrogen peroxide metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    insulin secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lactate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    maternal process involved in female pregnancy IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    membrane depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    membrane hyperpolarization ISO
    Inferred from Sequence Orthology
    more info
     
    methylglyoxal metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    NOT methylglyoxal metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    NOT methylglyoxal metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of NMDA glutamate receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of TRAIL-activated apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of TRAIL-activated apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of TRAIL-activated apoptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell death ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of hydrogen peroxide-induced cell death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of hydrogen peroxide-induced neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of neuron death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of oxidative stress-induced cell death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of oxidative stress-induced neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein K48-linked deubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein K48-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein K48-linked deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of protein acetylation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein acetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein export from nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein sumoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of reactive oxygen species biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of reactive oxygen species biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ubiquitin-specific protease activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of ubiquitin-specific protease activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ubiquitin-specific protease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-arginine deglycation IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-arginine deglycation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-cysteine deglycation IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-cysteine deglycation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-lysine deglycation IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-lysine deglycation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of L-dopa biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of L-dopa biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of L-dopa biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of L-dopa decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of L-dopa decarboxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of L-dopa decarboxylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of NAD(P)H oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NAD(P)H oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of acute inflammatory response to antigenic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of acute inflammatory response to antigenic stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of androgen receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of androgen receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of androgen receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of dopamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of dopamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dopamine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of fertilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-8 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-8 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of mitochondrial electron transport, NADH to ubiquinone IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of mitochondrial electron transport, NADH to ubiquinone ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitochondrial electron transport, NADH to ubiquinone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of oxidative phosphorylation uncoupler activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of oxidative phosphorylation uncoupler activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein localization to nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein localization to nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of pyrroline-5-carboxylate reductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of pyrroline-5-carboxylate reductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of pyrroline-5-carboxylate reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of reactive oxygen species biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of superoxide dismutase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of superoxide dismutase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of superoxide dismutase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription regulatory region DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tyrosine 3-monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of tyrosine 3-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tyrosine 3-monooxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein deglycation, glyoxal removal IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein deglycation, glyoxal removal IEA
    Inferred from Electronic Annotation
    more info
     
    protein deglycation, glyoxal removal ISO
    Inferred from Sequence Orthology
    more info
     
    protein deglycation, methylglyoxal removal IEA
    Inferred from Electronic Annotation
    more info
     
    protein deglycation, methylglyoxal removal ISO
    Inferred from Sequence Orthology
    more info
     
    NOT protein deglycation, methylglyoxal removal ISO
    Inferred from Sequence Orthology
    more info
     
    NOT protein deglycation, methylglyoxal removal ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein deglycosylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein deglycosylation ISO
    Inferred from Sequence Orthology
    more info
     
    NOT protein deglycosylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein deglycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT protein deglycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein stabilization IEA
    Inferred from Electronic Annotation
    more info
     
    protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    NOT regulation of TRAIL receptor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of androgen receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of mitochondrial membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitochondrial membrane potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neuron apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    single fertilization IEA
    Inferred from Electronic Annotation
    more info
     
    spermatogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    synaptic transmission, dopaminergic ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    PML body IEA
    Inferred from Electronic Annotation
    more info
     
    PML body ISO
    Inferred from Sequence Orthology
    more info
     
    PML body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell body ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial respiratory chain complex I IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with mitochondrial respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with mitochondrial respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    sperm head IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein/nucleic acid deglycase DJ-1
    Names
    Parkinson disease (autosomal recessive, early onset) 7
    contraception-associated protein 1
    fertility protein SP22
    maillard deglycase
    parkinson disease protein 7 homolog
    parkinson protein 7
    protein DJ-1
    protein deglycase DJ-1
    NP_001264178.1
    NP_001264179.1
    NP_001264180.1
    NP_001264181.1
    NP_001264182.1
    NP_476484.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277249.1NP_001264178.1  protein/nucleic acid deglycase DJ-1 isoform 1

      See identical proteins and their annotated locations for NP_001264178.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC115172, BC091128
      UniProtKB/TrEMBL
      Q5BKC3
      Related
      ENSRNOP00000074942.1, ENSRNOT00000091206.1
      Conserved Domains (1) summary
      cd03135
      Location:6141
      GATase1_DJ-1; Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1
    2. NM_001277250.1NP_001264179.1  protein/nucleic acid deglycase DJ-1 isoform 2

      See identical proteins and their annotated locations for NP_001264179.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate penultimate exon, compared to variant 1, resulting in a novel 3' coding region and 3' UTR. The encoded isoform (2) is shorter, compared to isoform 1. Variants 2, 3, 4, 5, and 6 encode the same isoform.
      Source sequence(s)
      AC115172, FM055257
      UniProtKB/Swiss-Prot
      O88767
      Conserved Domains (2) summary
      cd03135
      Location:6172
      GATase1_DJ-1; Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1
      TIGR01383
      Location:5184
      not_thiJ; DJ-1 family protein
    3. NM_001277251.1NP_001264180.1  protein/nucleic acid deglycase DJ-1 isoform 2

      See identical proteins and their annotated locations for NP_001264180.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and includes an alternate penultimate exon, compared to variant 1, resulting in a novel 3' coding region and 3' UTR. The encoded isoform (2) is shorter, compared to isoform 1. Variants 2, 3, 4, 5, and 6 encode the same isoform.
      Source sequence(s)
      AC115172, FM055257
      UniProtKB/Swiss-Prot
      O88767
      Conserved Domains (2) summary
      cd03135
      Location:6172
      GATase1_DJ-1; Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1
      TIGR01383
      Location:5184
      not_thiJ; DJ-1 family protein
    4. NM_001277252.1NP_001264181.1  protein/nucleic acid deglycase DJ-1 isoform 2

      See identical proteins and their annotated locations for NP_001264181.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and includes an alternate penultimate exon, compared to variant 1, resulting in a novel 3' coding region and 3' UTR. The encoded isoform (2) is shorter, compared to isoform 1. Variants 2, 3, 4, 5, and 6 encode the same isoform.
      Source sequence(s)
      AC115172, FM061417
      UniProtKB/Swiss-Prot
      O88767
      Conserved Domains (2) summary
      cd03135
      Location:6172
      GATase1_DJ-1; Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1
      TIGR01383
      Location:5184
      not_thiJ; DJ-1 family protein
    5. NM_001277253.1NP_001264182.1  protein/nucleic acid deglycase DJ-1 isoform 2

      See identical proteins and their annotated locations for NP_001264182.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and includes an alternate penultimate exon, compared to variant 1, resulting in a novel 3' coding region and 3' UTR. The encoded isoform (2) is shorter, compared to isoform 1. Variants 2, 3, 4, 5, and 6 encode the same isoform.
      Source sequence(s)
      AC115172, FM069664
      UniProtKB/Swiss-Prot
      O88767
      Related
      ENSRNOP00000024711.2, ENSRNOT00000024711.5
      Conserved Domains (2) summary
      cd03135
      Location:6172
      GATase1_DJ-1; Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1
      TIGR01383
      Location:5184
      not_thiJ; DJ-1 family protein
    6. NM_057143.2NP_476484.1  protein/nucleic acid deglycase DJ-1 isoform 2

      See identical proteins and their annotated locations for NP_476484.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and includes an alternate penultimate exon, compared to variant 1, resulting in a novel 3' coding region and 3' UTR. The encoded isoform (2) is shorter, compared to isoform 1. Variants 2, 3, 4, 5, and 6 encode the same isoform.
      Source sequence(s)
      AC115172, FM055257
      UniProtKB/Swiss-Prot
      O88767
      Related
      ENSRNOP00000072068.1, ENSRNOT00000087402.1
      Conserved Domains (2) summary
      cd03135
      Location:6172
      GATase1_DJ-1; Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1
      TIGR01383
      Location:5184
      not_thiJ; DJ-1 family protein

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005104.4 Reference Rnor_6.0 Primary Assembly

      Range
      167982438..168004724 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000073.1 Alternate Rn_Celera

      Range
      159607648..159630713 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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