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    ZNF653 zinc finger protein 653 [ Homo sapiens (human) ]

    Gene ID: 115950, updated on 17-Jun-2024

    Summary

    Official Symbol
    ZNF653provided by HGNC
    Official Full Name
    zinc finger protein 653provided by HGNC
    Primary source
    HGNC:HGNC:25196
    See related
    Ensembl:ENSG00000161914 MIM:611371; AllianceGenome:HGNC:25196
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZIP67; E430039K05Rik
    Summary
    Enables AF-2 domain binding activity and transcription corepressor activity. Involved in extracellular negative regulation of signal transduction and negative regulation of nucleic acid-templated transcription. Predicted to be located in extracellular region. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 5.2), brain (RPKM 2.1) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ZNF653 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (11483429..11505839, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (11610937..11633342, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11594244..11616654, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904800 Neighboring gene PRKCSH beta subunit of glucosidase II Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14019 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11563051-11563821 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:11564685-11564866 Neighboring gene ELAV like RNA binding protein 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:11590379-11590573 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10112 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10113 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10114 Neighboring gene microRNA 7974 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14021 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10115 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10116 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11618272-11619049 Neighboring gene ECSIT signaling integrator Neighboring gene RNA, 7SL, cytoplasmic 833, pseudogene Neighboring gene ribosomal protein L18a pseudogene 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables AF-2 domain binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IC
    Inferred by Curator
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc finger protein 653
    Names
    67 kDa zinc finger protein
    zinc finger protein Zip67

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138783.4NP_620138.2  zinc finger protein 653

      See identical proteins and their annotated locations for NP_620138.2

      Status: VALIDATED

      Source sequence(s)
      AK131037, BC014187, CB241280
      Consensus CDS
      CCDS12261.1
      UniProtKB/Swiss-Prot
      Q96AS7, Q96CK0
      Related
      ENSP00000293771.3, ENST00000293771.10
      Conserved Domains (3) summary
      COG5048
      Location:486614
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:503522
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:514539
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      11483429..11505839 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      11610937..11633342 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)