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    Zbtb21 zinc finger and BTB domain containing 21 [ Mus musculus (house mouse) ]

    Gene ID: 114565, updated on 23-May-2018
    Official Symbol
    Zbtb21provided by MGI
    Official Full Name
    zinc finger and BTB domain containing 21provided by MGI
    Primary source
    MGI:MGI:1927240
    See related
    Ensembl:ENSMUSG00000046962
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp295; Znf295; mKIAA1227; 5430437K12Rik; B430213I24Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 2.0), limb E14.5 (RPKM 1.7) and 28 other tissues See more
    Orthologs
    See Zbtb21 in Genome Data Viewer
    Location:
    16; 16 C4
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (97945793..97962623, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (98168599..98183786, complement)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene C2 calcium-dependent domain containing 2 Neighboring gene microRNA 6964 Neighboring gene predicted gene, 41514 Neighboring gene RIKEN cDNA C030010L15 gene Neighboring gene RIKEN cDNA B230307C23 gene Neighboring gene RIKEN cDNA B230307C23 gene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    methyl-CpG binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    negative regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    zinc finger and BTB domain-containing protein 21
    Names
    zinc finger protein 295

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081684.2NP_001075153.1  zinc finger and BTB domain-containing protein 21 isoform 2

      See identical proteins and their annotated locations for NP_001075153.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks part of the 5' coding region and uses a downstream in-frame start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC226122, AK034057
      Consensus CDS
      CCDS37420.1
      UniProtKB/TrEMBL
      E9Q3R9, Q8CC25
      Related
      ENSMUSP00000068283.7, ENSMUST00000063605.13
      Conserved Domains (4) summary
      smart00225
      Location:31116
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:551572
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:911931
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:20120
      BTB; BTB/POZ domain
    2. NM_001081685.2NP_001075154.1  zinc finger and BTB domain-containing protein 21 isoform 3

      See identical proteins and their annotated locations for NP_001075154.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses alternate splicing in the coding region but maintains the reading frame compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC226122, AK031118, AK034057
      Consensus CDS
      CCDS37419.1
      UniProtKB/TrEMBL
      G3X9A3, Q8BSP5, Q8CC25
      Related
      ENSMUSP00000052127.7, ENSMUST00000052089.7
      Conserved Domains (3) summary
      smart00225
      Location:59144
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00019
      Location:739759
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:48148
      BTB; BTB/POZ domain
    3. NM_001320385.1NP_001307314.1  zinc finger and BTB domain-containing protein 21 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks part of the 5' coding region, uses a downstream in-frame start codon, and uses alternate splicing in the coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AC226122, AK034057
      UniProtKB/TrEMBL
      Q80XC5, Q8CC25
      Conserved Domains (2) summary
      sd00019
      Location:225245
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02518
      Location:2051
      BTB; BTB/POZ domain
    4. NM_175428.4NP_780637.2  zinc finger and BTB domain-containing protein 21 isoform 1

      See identical proteins and their annotated locations for NP_780637.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC226122, AK034057
      Consensus CDS
      CCDS37418.1
      UniProtKB/TrEMBL
      E9Q444, Q8CC25
      Related
      ENSMUSP00000109363.2, ENSMUST00000113734.8
      Conserved Domains (4) summary
      smart00225
      Location:59144
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:579600
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:939959
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:48148
      BTB; BTB/POZ domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      97945793..97962623 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316853.1XP_017172342.1  zinc finger and BTB domain-containing protein 21 isoform X1

      UniProtKB/TrEMBL
      E9Q444
      Conserved Domains (4) summary
      smart00225
      Location:59144
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:579600
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:939959
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:48148
      BTB; BTB/POZ domain
    2. XM_006522857.3XP_006522920.1  zinc finger and BTB domain-containing protein 21 isoform X1

      See identical proteins and their annotated locations for XP_006522920.1

      UniProtKB/TrEMBL
      E9Q444
      Conserved Domains (4) summary
      smart00225
      Location:59144
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:579600
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:939959
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:48148
      BTB; BTB/POZ domain
    3. XM_006522861.3XP_006522924.1  zinc finger and BTB domain-containing protein 21 isoform X3

      Conserved Domains (2) summary
      sd00019
      Location:253273
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02518
      Location:4879
      BTB; BTB/POZ domain
    4. XM_006522860.3XP_006522923.1  zinc finger and BTB domain-containing protein 21 isoform X2

      See identical proteins and their annotated locations for XP_006522923.1

      UniProtKB/TrEMBL
      E9Q3R9
      Conserved Domains (4) summary
      smart00225
      Location:31116
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:551572
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:911931
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:20120
      BTB; BTB/POZ domain
    5. XM_006522858.3XP_006522921.1  zinc finger and BTB domain-containing protein 21 isoform X1

      See identical proteins and their annotated locations for XP_006522921.1

      UniProtKB/TrEMBL
      E9Q444
      Conserved Domains (4) summary
      smart00225
      Location:59144
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:579600
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:939959
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:48148
      BTB; BTB/POZ domain
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