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    Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 [ Mus musculus (house mouse) ]

    Gene ID: 11421, updated on 3-Jun-2018
    Official Symbol
    Aceprovided by MGI
    Official Full Name
    angiotensin I converting enzyme (peptidyl-dipeptidase A) 1provided by MGI
    Primary source
    MGI:MGI:87874
    See related
    Ensembl:ENSMUSG00000020681 Vega:OTTMUSG00000003113
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD143; AW208573
    Expression
    Biased expression in lung adult (RPKM 304.6), duodenum adult (RPKM 225.6) and 6 other tissues See more
    Orthologs
    See Ace in Genome Data Viewer
    Location:
    11 E1; 11 68.84 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (105967945..105989964)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (105829261..105851259)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 Neighboring gene snurportin 1 pseudogene Neighboring gene predicted gene, 46296 Neighboring gene cytochrome b-561 Neighboring gene predicted gene 11651 Neighboring gene predicted gene, 35971 Neighboring gene angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 6

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • ACE Inhibitor Pathway, organism-specific biosystem (from WikiPathways)
      ACE Inhibitor Pathway, organism-specific biosystemThe renin-angiotensin-aldosterone system (RAAS) is central to the control of blood pressure and the target of several types of anti-hypertensive drugs. This pathway depicts a simplified representatio...
    • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Metabolism of Angiotensinogen to Angiotensins, organism-specific biosystem (from REACTOME)
      Metabolism of Angiotensinogen to Angiotensins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Peptide hormone metabolism, organism-specific biosystem (from REACTOME)
      Peptide hormone metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Renin secretion, organism-specific biosystem (from KEGG)
      Renin secretion, organism-specific biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
    • Renin secretion, conserved biosystem (from KEGG)
      Renin secretion, conserved biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
    • Renin-angiotensin system, organism-specific biosystem (from KEGG)
      Renin-angiotensin system, organism-specific biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...
    • Renin-angiotensin system, conserved biosystem (from KEGG)
      Renin-angiotensin system, conserved biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC117827

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    bradykinin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    chloride ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    dipeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    drug binding ISO
    Inferred from Sequence Orthology
    more info
     
    endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    exopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    exopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metallodipeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    metallopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    metallopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    mitogen-activated protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    mitogen-activated protein kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    peptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-dipeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-dipeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-dipeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    tripeptidyl-peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    amyloid-beta metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    angiogenesis involved in coronary vascular morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    animal organ regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    arachidonic acid secretion ISO
    Inferred from Sequence Orthology
    more info
     
    bradykinin catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    cell proliferation in bone marrow IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    eating behavior ISO
    Inferred from Sequence Orthology
    more info
     
    embryo development ending in birth or egg hatching ISO
    Inferred from Sequence Orthology
    more info
     
    heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hormone catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hormone catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    lung alveolus development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of blood vessel diameter ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of calcium ion import ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gap junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of renal sodium excretion ISO
    Inferred from Sequence Orthology
    more info
     
    neutrophil mediated immunity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptide catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    peptide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of blood pressure IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-cysteine S-nitrosylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of systemic arterial blood pressure IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of systemic arterial blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of systemic arterial blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    posttranscriptional regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of angiotensin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of blood pressure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of hematopoietic stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of systemic arterial blood pressure by renin-angiotensin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of systemic arterial blood pressure by renin-angiotensin ISO
    Inferred from Sequence Orthology
    more info
     
    response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    brush border membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    sperm midpiece ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    angiotensin-converting enzyme
    Names
    dipeptidyl carboxypeptidase I
    dipeptidyl peptidase
    kininase II
    NP_001268748.1
    NP_033728.1
    NP_997507.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281819.1NP_001268748.1  angiotensin-converting enzyme isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate segment in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK161020, AK164780, AL731865, BY210311
      UniProtKB/TrEMBL
      Q3TU20
      Related
      ENSMUSP00000119826.1, OTTMUSP00000003022, ENSMUST00000132280.7, OTTMUST00000006416
      Conserved Domains (1) summary
      pfam01401
      Location:6491226
      Peptidase_M2; Angiotensin-converting enzyme
    2. NM_009598.2NP_033728.1  angiotensin-converting enzyme isoform 2 precursor

      See identical proteins and their annotated locations for NP_033728.1

      Status: VALIDATED

      Description
      Transcript Variant: The variant (2) differs in the 5' UTR and lacks multiple 5' coding exons, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK164780, AL731865, M55333
      Consensus CDS
      CCDS25544.1
      UniProtKB/Swiss-Prot
      P09470
      Related
      ENSMUSP00000001964.7, OTTMUSP00000003023, ENSMUST00000001964.7, OTTMUST00000006417
      Conserved Domains (1) summary
      pfam01401
      Location:69646
      Peptidase_M2; Angiotensin-converting enzyme
    3. NM_207624.5NP_997507.1  angiotensin-converting enzyme isoform 1 precursor

      See identical proteins and their annotated locations for NP_997507.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK161020, AL731865, BY210311
      Consensus CDS
      CCDS25543.1
      UniProtKB/Swiss-Prot
      P09470
      UniProtKB/TrEMBL
      Q3TU20
      Related
      ENSMUSP00000001963.7, OTTMUSP00000003021, ENSMUST00000001963.13, OTTMUST00000006415
      Conserved Domains (1) summary
      pfam01401
      Location:6491226
      Peptidase_M2; Angiotensin-converting enzyme

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      105967945..105989964
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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