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    LDB3 LIM domain binding 3 [ Homo sapiens (human) ]

    Gene ID: 11155, updated on 8-Sep-2018

    Summary

    Official Symbol
    LDB3provided by HGNC
    Official Full Name
    LIM domain binding 3provided by HGNC
    Primary source
    HGNC:HGNC:15710
    See related
    Ensembl:ENSG00000122367 MIM:605906; Vega:OTTHUMG00000018655
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MFM4; ZASP; CMD1C; CMH24; CMPD3; LVNC3; CYPHER; LDB3Z1; LDB3Z4; ORACLE; PDLIM6
    Summary
    This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains. [provided by RefSeq, Jan 2010]
    Annotation information
    Note: LDB3 (Gene ID: 11155) and ZASP (Gene ID: 101927655) share the ZASP alias/unofficial symbol in common. [01 Jun 2018]
    Expression
    Biased expression in heart (RPKM 95.5), prostate (RPKM 11.4) and 1 other tissue See more
    Orthologs

    Genomic context

    See LDB3 in Genome Data Viewer
    Location:
    10q23.2
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (86664785..86736072)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (88426542..88495829)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378406 Neighboring gene ribosomal protein L7a pseudogene 8 Neighboring gene uncharacterized LOC105378409 Neighboring gene VISTA enhancer hs2143 Neighboring gene opsin 4 Neighboring gene bone morphogenetic protein receptor type 1A Neighboring gene RNA polymerase II associated protein 2 pseudogene 1 Neighboring gene RNA, U1 small nuclear 19, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ35865, KIAA0613, KIAA01613

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytoskeletal protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    muscle alpha-actinin binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase C binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    sarcomere organization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    pseudopodium IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    LIM domain-binding protein 3
    Names
    PDZ and LIM domain 6
    Z-band alternatively spliced PDZ-motif protein
    cardiomyopathy, dilated 1C (autosomal dominant)
    protein cypher

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008876.1 RefSeqGene

      Range
      4886..72505
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_385

    mRNA and Protein(s)

    1. NM_001080114.1NP_001073583.1  LIM domain-binding protein 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter but with the same N- and C-termini, when it is compared to isoform 1.
      Source sequence(s)
      AA180065, AB014513, AC067750, AL601484, DA762127
      Consensus CDS
      CCDS41544.1
      UniProtKB/Swiss-Prot
      O75112
      Related
      ENSP00000263066.6, OTTHUMP00000277821, ENST00000263066.10, OTTHUMT00000478968
      Conserved Domains (6) summary
      cd09362
      Location:500551
      LIM2_Enigma_like; The second LIM domain of Enigma-like family
      cd09363
      Location:559612
      LIM3_Enigma_like; The third LIM domain of Enigma-like family
      cd09454
      Location:441492
      LIM1_ZASP_Cypher; The first LIM domain of ZASP/Cypher family
      cd00992
      Location:581
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15936
      Location:148238
      DUF4749; Domain of unknown function (DUF4749)
      cl26464
      Location:272439
      Atrophin-1; Atrophin-1 family
    2. NM_001080115.1NP_001073584.1  LIM domain-binding protein 3 isoform 3

      See identical proteins and their annotated locations for NP_001073584.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks several segments and uses a different 3' segment in its coding region, compared to variant 1. The resulting protein (isoform 3) is shorter with a distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AF276807, BC010929, F33274
      Consensus CDS
      CCDS44450.1
      UniProtKB/Swiss-Prot
      O75112
      UniProtKB/TrEMBL
      A0A0S2Z501
      Related
      ENSP00000485389.1, OTTHUMP00000277819, ENST00000623007.3, OTTHUMT00000478966
      Conserved Domains (3) summary
      cd00992
      Location:581
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15936
      Location:194285
      DUF4749; Domain of unknown function (DUF4749)
      cl25751
      Location:77180
      DUF4045; Domain of unknown function (DUF4045)
    3. NM_001080116.1NP_001073585.1  LIM domain-binding protein 3 isoform 4

      See identical proteins and their annotated locations for NP_001073585.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has multiple differences, including a different 3' segment, in its coding region, compared to variant 1. The resulting protein (isoform 4) is shorter and has a distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AJ133766, BC010929, DA898241, F33274
      Consensus CDS
      CCDS41545.1
      UniProtKB/Swiss-Prot
      O75112
      UniProtKB/TrEMBL
      A0A0S2Z530
      Related
      ENSP00000361136.3, OTTHUMP00000020009, ENST00000372066.7, OTTHUMT00000049161
      Conserved Domains (2) summary
      cd00992
      Location:581
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15936
      Location:148238
      DUF4749; Domain of unknown function (DUF4749)
    4. NM_001171610.1NP_001165081.1  LIM domain-binding protein 3 isoform 5

      See identical proteins and their annotated locations for NP_001165081.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has multiple differences in the coding region, compared to variant 1. The encoded isoform (5) is longer than isoform 1.
      Source sequence(s)
      AC067750, AK304760, DC357269
      Consensus CDS
      CCDS53550.1
      UniProtKB/Swiss-Prot
      O75112
      Related
      ENSP00000401437.2, ENST00000429277.6
      Conserved Domains (8) summary
      smart00735
      Location:189214
      ZM; ZASP-like motif
      cd09362
      Location:615666
      LIM2_Enigma_like; The second LIM domain of Enigma-like family
      cd09363
      Location:674727
      LIM3_Enigma_like; The third LIM domain of Enigma-like family
      cd09454
      Location:556607
      LIM1_ZASP_Cypher; The first LIM domain of ZASP/Cypher family
      cd00992
      Location:581
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15936
      Location:263353
      DUF4749; Domain of unknown function (DUF4749)
      cl25751
      Location:77180
      DUF4045; Domain of unknown function (DUF4045)
      cl26464
      Location:387554
      Atrophin-1; Atrophin-1 family
    5. NM_001171611.1NP_001165082.1  LIM domain-binding protein 3 isoform 6

      See identical proteins and their annotated locations for NP_001165082.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 3' UTR and has multiple differences in the coding region, compared to variant 1. The encoded isoform (6) is shorter and has a distinct C-terminus, compared to isoform (1).
      Source sequence(s)
      AC067750, AF276809
      Consensus CDS
      CCDS53549.1
      UniProtKB/Swiss-Prot
      O75112
      Related
      ENSP00000361126.4, OTTHUMP00000277820, ENST00000372056.8, OTTHUMT00000478967
      Conserved Domains (4) summary
      cd00992
      Location:581
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15936
      Location:263353
      DUF4749; Domain of unknown function (DUF4749)
      cl25751
      Location:77180
      DUF4045; Domain of unknown function (DUF4045)
      cl25776
      Location:189214
      DUF4749; Domain of unknown function (DUF4749)
    6. NM_007078.2NP_009009.1  LIM domain-binding protein 3 isoform 1

      See identical proteins and their annotated locations for NP_009009.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AA180065, AB014513, AC067750, BC010929
      Consensus CDS
      CCDS7377.1
      UniProtKB/Swiss-Prot
      O75112
      Related
      ENSP00000355296.3, OTTHUMP00000020008, ENST00000361373.8, OTTHUMT00000049160
      Conserved Domains (6) summary
      cd09362
      Location:610661
      LIM2_Enigma_like; The second LIM domain of Enigma-like family
      cd09363
      Location:669722
      LIM3_Enigma_like; The third LIM domain of Enigma-like family
      cd09454
      Location:551602
      LIM1_ZASP_Cypher; The first LIM domain of ZASP/Cypher family
      cd00992
      Location:581
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15936
      Location:194285
      DUF4749; Domain of unknown function (DUF4749)
      cl26386
      Location:352550
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

      Range
      86664785..86736072
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011539185.2XP_011537487.1  LIM domain-binding protein 3 isoform X1

      See identical proteins and their annotated locations for XP_011537487.1

      Conserved Domains (7) summary
      smart00735
      Location:189214
      ZM; ZASP-like motif
      cd09362
      Location:694745
      LIM2_Enigma_like; The second LIM domain of Enigma-like family
      cd09363
      Location:753806
      LIM3_Enigma_like; The third LIM domain of Enigma-like family
      cd09454
      Location:635686
      LIM1_ZASP_Cypher; The first LIM domain of ZASP/Cypher family
      cd00992
      Location:581
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam05687
      Location:492551
      BES1_N; BES1/BZR1 plant transcription factor, N-terminal
      pfam15936
      Location:263357
      DUF4749; Domain of unknown function (DUF4749)
    2. XM_017015606.1XP_016871095.1  LIM domain-binding protein 3 isoform X4

      Conserved Domains (6) summary
      cd09362
      Location:626677
      LIM2_Enigma_like; The second LIM domain of Enigma-like family
      cd09363
      Location:685738
      LIM3_Enigma_like; The third LIM domain of Enigma-like family
      cd09454
      Location:567618
      LIM1_ZASP_Cypher; The first LIM domain of ZASP/Cypher family
      cd00992
      Location:581
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam05687
      Location:424483
      BES1_N; BES1/BZR1 plant transcription factor, N-terminal
      pfam15936
      Location:194289
      DUF4749; Domain of unknown function (DUF4749)
    3. XM_017015608.1XP_016871097.1  LIM domain-binding protein 3 isoform X14

      UniProtKB/Swiss-Prot
      O75112
      UniProtKB/TrEMBL
      A0A0S2Z501
      Conserved Domains (3) summary
      cd00992
      Location:581
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15936
      Location:194285
      DUF4749; Domain of unknown function (DUF4749)
      cl25751
      Location:77180
      DUF4045; Domain of unknown function (DUF4045)
    4. XM_011539189.1XP_011537491.1  LIM domain-binding protein 3 isoform X6

      Conserved Domains (6) summary
      cd09362
      Location:579630
      LIM2_Enigma_like; The second LIM domain of Enigma-like family
      cd09363
      Location:638691
      LIM3_Enigma_like; The third LIM domain of Enigma-like family
      cd09454
      Location:520571
      LIM1_ZASP_Cypher; The first LIM domain of ZASP/Cypher family
      cd00992
      Location:581
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15936
      Location:148238
      DUF4749; Domain of unknown function (DUF4749)
      cl26464
      Location:304521
      Atrophin-1; Atrophin-1 family
    5. XM_011539193.1XP_011537495.1  LIM domain-binding protein 3 isoform X11

      Conserved Domains (3) summary
      cd09454
      Location:287338
      LIM1_ZASP_Cypher; The first LIM domain of ZASP/Cypher family
      pfam05687
      Location:144203
      BES1_N; BES1/BZR1 plant transcription factor, N-terminal
      cl02475
      Location:405459
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    6. XM_011539194.1XP_011537496.1  LIM domain-binding protein 3 isoform X12

      Conserved Domains (3) summary
      cd09454
      Location:224275
      LIM1_ZASP_Cypher; The first LIM domain of ZASP/Cypher family
      pfam05687
      Location:81140
      BES1_N; BES1/BZR1 plant transcription factor, N-terminal
      cl02475
      Location:342396
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    7. XM_017015609.1XP_016871098.1  LIM domain-binding protein 3 isoform X15

      UniProtKB/Swiss-Prot
      O75112
      UniProtKB/TrEMBL
      A0A0S2Z530
      Conserved Domains (2) summary
      cd00992
      Location:581
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15936
      Location:148238
      DUF4749; Domain of unknown function (DUF4749)
    8. XM_011539184.2XP_011537486.1  LIM domain-binding protein 3 isoform X1

      See identical proteins and their annotated locations for XP_011537486.1

      Conserved Domains (7) summary
      smart00735
      Location:189214
      ZM; ZASP-like motif
      cd09362
      Location:694745
      LIM2_Enigma_like; The second LIM domain of Enigma-like family
      cd09363
      Location:753806
      LIM3_Enigma_like; The third LIM domain of Enigma-like family
      cd09454
      Location:635686
      LIM1_ZASP_Cypher; The first LIM domain of ZASP/Cypher family
      cd00992
      Location:581
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam05687
      Location:492551
      BES1_N; BES1/BZR1 plant transcription factor, N-terminal
      pfam15936
      Location:263357
      DUF4749; Domain of unknown function (DUF4749)
    9. XM_011539186.2XP_011537488.1  LIM domain-binding protein 3 isoform X2

      Conserved Domains (7) summary
      smart00735
      Location:189214
      ZM; ZASP-like motif
      cd09362
      Location:678729
      LIM2_Enigma_like; The second LIM domain of Enigma-like family
      cd09363
      Location:737790
      LIM3_Enigma_like; The third LIM domain of Enigma-like family
      cd09454
      Location:619670
      LIM1_ZASP_Cypher; The first LIM domain of ZASP/Cypher family
      cd00992
      Location:581
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam05687
      Location:486535
      BES1_N; BES1/BZR1 plant transcription factor, N-terminal
      pfam15936
      Location:263357
      DUF4749; Domain of unknown function (DUF4749)
    10. XM_011539188.2XP_011537490.1  LIM domain-binding protein 3 isoform X4

      Conserved Domains (6) summary
      cd09362
      Location:626677
      LIM2_Enigma_like; The second LIM domain of Enigma-like family
      cd09363
      Location:685738
      LIM3_Enigma_like; The third LIM domain of Enigma-like family
      cd09454
      Location:567618
      LIM1_ZASP_Cypher; The first LIM domain of ZASP/Cypher family
      cd00992
      Location:581
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam05687
      Location:424483
      BES1_N; BES1/BZR1 plant transcription factor, N-terminal
      pfam15936
      Location:194289
      DUF4749; Domain of unknown function (DUF4749)
    11. XM_011539187.2XP_011537489.1  LIM domain-binding protein 3 isoform X3

      Conserved Domains (7) summary
      smart00735
      Location:189214
      ZM; ZASP-like motif
      cd09362
      Location:631682
      LIM2_Enigma_like; The second LIM domain of Enigma-like family
      cd09363
      Location:690743
      LIM3_Enigma_like; The third LIM domain of Enigma-like family
      cd09454
      Location:572623
      LIM1_ZASP_Cypher; The first LIM domain of ZASP/Cypher family
      cd00992
      Location:581
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam05687
      Location:429488
      BES1_N; BES1/BZR1 plant transcription factor, N-terminal
      pfam15936
      Location:263357
      DUF4749; Domain of unknown function (DUF4749)
    12. XM_005269464.4XP_005269521.1  LIM domain-binding protein 3 isoform X5

      See identical proteins and their annotated locations for XP_005269521.1

      UniProtKB/Swiss-Prot
      O75112
      Conserved Domains (6) summary
      cd09362
      Location:610661
      LIM2_Enigma_like; The second LIM domain of Enigma-like family
      cd09363
      Location:669722
      LIM3_Enigma_like; The third LIM domain of Enigma-like family
      cd09454
      Location:551602
      LIM1_ZASP_Cypher; The first LIM domain of ZASP/Cypher family
      cd00992
      Location:581
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15936
      Location:194285
      DUF4749; Domain of unknown function (DUF4749)
      cl26386
      Location:352550
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    13. XM_024447785.1XP_024303553.1  LIM domain-binding protein 3 isoform X6

      Conserved Domains (6) summary
      cd09362
      Location:579630
      LIM2_Enigma_like; The second LIM domain of Enigma-like family
      cd09363
      Location:638691
      LIM3_Enigma_like; The third LIM domain of Enigma-like family
      cd09454
      Location:520571
      LIM1_ZASP_Cypher; The first LIM domain of ZASP/Cypher family
      cd00992
      Location:581
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15936
      Location:148238
      DUF4749; Domain of unknown function (DUF4749)
      cl26464
      Location:304521
      Atrophin-1; Atrophin-1 family
    14. XM_011539191.2XP_011537493.1  LIM domain-binding protein 3 isoform X9

      Conserved Domains (6) summary
      cd09362
      Location:516567
      LIM2_Enigma_like; The second LIM domain of Enigma-like family
      cd09363
      Location:575628
      LIM3_Enigma_like; The third LIM domain of Enigma-like family
      cd09454
      Location:457508
      LIM1_ZASP_Cypher; The first LIM domain of ZASP/Cypher family
      cd00992
      Location:581
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam05687
      Location:314373
      BES1_N; BES1/BZR1 plant transcription factor, N-terminal
      pfam15936
      Location:123179
      DUF4749; Domain of unknown function (DUF4749)
    15. XM_005269466.4XP_005269523.1  LIM domain-binding protein 3 isoform X8

      See identical proteins and their annotated locations for XP_005269523.1

      UniProtKB/TrEMBL
      V5T7C5
      Conserved Domains (6) summary
      cd09362
      Location:547598
      LIM2_Enigma_like; The second LIM domain of Enigma-like family
      cd09363
      Location:606659
      LIM3_Enigma_like; The third LIM domain of Enigma-like family
      cd09454
      Location:488539
      LIM1_ZASP_Cypher; The first LIM domain of ZASP/Cypher family
      cd00992
      Location:581
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam05687
      Location:355404
      BES1_N; BES1/BZR1 plant transcription factor, N-terminal
      pfam15936
      Location:194289
      DUF4749; Domain of unknown function (DUF4749)
    16. XM_011539190.2XP_011537492.1  LIM domain-binding protein 3 isoform X7

      Conserved Domains (6) summary
      cd09362
      Location:563614
      LIM2_Enigma_like; The second LIM domain of Enigma-like family
      cd09363
      Location:622675
      LIM3_Enigma_like; The third LIM domain of Enigma-like family
      cd09454
      Location:504555
      LIM1_ZASP_Cypher; The first LIM domain of ZASP/Cypher family
      cd00992
      Location:581
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam05687
      Location:371420
      BES1_N; BES1/BZR1 plant transcription factor, N-terminal
      pfam15936
      Location:148242
      DUF4749; Domain of unknown function (DUF4749)
    17. XM_024447786.1XP_024303554.1  LIM domain-binding protein 3 isoform X10

      Conserved Domains (6) summary
      cd09362
      Location:500551
      LIM2_Enigma_like; The second LIM domain of Enigma-like family
      cd09363
      Location:559612
      LIM3_Enigma_like; The third LIM domain of Enigma-like family
      cd09454
      Location:441492
      LIM1_ZASP_Cypher; The first LIM domain of ZASP/Cypher family
      cd00992
      Location:581
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15936
      Location:148238
      DUF4749; Domain of unknown function (DUF4749)
      cl26464
      Location:272439
      Atrophin-1; Atrophin-1 family
    18. XM_011539195.2XP_011537497.1  LIM domain-binding protein 3 isoform X13

      See identical proteins and their annotated locations for XP_011537497.1

      UniProtKB/Swiss-Prot
      O75112
      Conserved Domains (4) summary
      cd00992
      Location:581
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15936
      Location:263353
      DUF4749; Domain of unknown function (DUF4749)
      cl25751
      Location:77180
      DUF4045; Domain of unknown function (DUF4045)
      cl25776
      Location:189214
      DUF4749; Domain of unknown function (DUF4749)
    19. XM_005269468.4XP_005269525.1  LIM domain-binding protein 3 isoform X14

      See identical proteins and their annotated locations for XP_005269525.1

      UniProtKB/Swiss-Prot
      O75112
      UniProtKB/TrEMBL
      A0A0S2Z501
      Conserved Domains (3) summary
      cd00992
      Location:581
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15936
      Location:194285
      DUF4749; Domain of unknown function (DUF4749)
      cl25751
      Location:77180
      DUF4045; Domain of unknown function (DUF4045)
    20. XM_024447787.1XP_024303555.1  LIM domain-binding protein 3 isoform X15

      Conserved Domains (2) summary
      cd00992
      Location:581
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15936
      Location:148238
      DUF4749; Domain of unknown function (DUF4749)
    21. XM_017015607.1XP_016871096.1  LIM domain-binding protein 3 isoform X11

      Conserved Domains (3) summary
      cd09454
      Location:287338
      LIM1_ZASP_Cypher; The first LIM domain of ZASP/Cypher family
      pfam05687
      Location:144203
      BES1_N; BES1/BZR1 plant transcription factor, N-terminal
      cl02475
      Location:405459
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
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