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    Fntb farnesyltransferase, CAAX box, beta [ Mus musculus (house mouse) ]

    Gene ID: 110606, updated on 9-Sep-2018

    Summary

    Official Symbol
    Fntbprovided by MGI
    Official Full Name
    farnesyltransferase, CAAX box, betaprovided by MGI
    Primary source
    MGI:MGI:1861305
    See related
    Ensembl:ENSMUSG00000033373 Vega:OTTMUSG00000033888
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AA409500; 2010013E13Rik
    Expression
    Ubiquitous expression in ovary adult (RPKM 14.1), limb E14.5 (RPKM 12.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Fntb in Genome Data Viewer
    Location:
    12 C3; 12 33.73 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (76837391..76921412)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (77938454..78022399)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene glutathione peroxidase 2 Neighboring gene RAB15, member RAS oncogene family Neighboring gene predicted gene, 34988 Neighboring gene predicted gene, 46357 Neighboring gene predicted gene, 46358 Neighboring gene Max protein Neighboring gene predicted gene, 35041

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to drug binding ISO
    Inferred from Sequence Orthology
    more info
     
    farnesyltranstransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    contributes_to isoprenoid binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to peptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    prenyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to protein farnesyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein farnesyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to protein farnesyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of nitric-oxide synthase biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein farnesylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein farnesylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein prenylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to cytokine ISO
    Inferred from Sequence Orthology
    more info
     
    response to inorganic substance ISO
    Inferred from Sequence Orthology
    more info
     
    response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    wound healing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    microtubule associated complex ISO
    Inferred from Sequence Orthology
    more info
     
    protein farnesyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein farnesyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein farnesyltransferase subunit beta
    Names
    CAAX farnesyltransferase subunit beta
    FTase-beta
    ras proteins prenyltransferase subunit beta
    NP_666039.1
    XP_006515467.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145927.2NP_666039.1  protein farnesyltransferase subunit beta

      See identical proteins and their annotated locations for NP_666039.1

      Status: PROVISIONAL

      Source sequence(s)
      AC124556, AC132331
      Consensus CDS
      CCDS25998.1
      UniProtKB/Swiss-Prot
      Q8K2I1
      Related
      ENSMUSP00000035498.9, OTTMUSP00000046168, ENSMUST00000041008.9, OTTMUST00000085462
      Conserved Domains (2) summary
      PLN02710
      Location:42419
      PLN02710; farnesyltranstransferase subunit beta
      cd02893
      Location:75373
      FTase; Protein farnesyltransferase (FTase)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). FTases are a subgroup of PTase family of lipid-modifying enzymes. PTases catalyze the ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      76837391..76921412
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515404.2XP_006515467.1  protein farnesyltransferase subunit beta isoform X1

      Conserved Domains (1) summary
      cd02893
      Location:1181
      FTase; Protein farnesyltransferase (FTase)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). FTases are a subgroup of PTase family of lipid-modifying enzymes. PTases catalyze the ...

    RNA

    1. XR_001780410.1 RNA Sequence

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