Format

Send to:

Choose Destination
    • Showing Current items.

    ADAP1 ArfGAP with dual PH domains 1 [ Homo sapiens (human) ]

    Gene ID: 11033, updated on 5-Sep-2021

    Summary

    Official Symbol
    ADAP1provided by HGNC
    Official Full Name
    ArfGAP with dual PH domains 1provided by HGNC
    Primary source
    HGNC:HGNC:16486
    See related
    Ensembl:ENSG00000105963 MIM:608114
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GCS1L; CENTA1; p42IP4
    Expression
    Broad expression in brain (RPKM 18.4), colon (RPKM 17.8) and 18 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ADAP1 in Genome Data Viewer
    Location:
    7p22.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (897900..955407, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (937537..995043, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene Sad1 and UNC84 domain containing 1 Neighboring gene guided entry of tail-anchored proteins factor 4 Neighboring gene cytochrome c oxidase assembly factor COX19 Neighboring gene chromosome 7 open reading frame 50 Neighboring gene cytochrome P450 family 2 subfamily W member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: COX19

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables inositol 1,3,4,5 tetrakisphosphate binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol bisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-3,4,5-trisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    arf-GAP with dual PH domain-containing protein 1
    Names
    centaurin-alpha
    centaurin-alpha-1
    cnt-a1
    putative MAPK-activating protein PM25

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284308.1NP_001271237.1  arf-GAP with dual PH domain-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001271237.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon and initiates translation from an alternate upstream start codon compared to variant 1. The resulting longer isoform (2) has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AI910700, AK300999, BC033747
      Consensus CDS
      CCDS64577.1
      UniProtKB/Swiss-Prot
      O75689
      Related
      ENSP00000442682.1, ENST00000539900.5
      Conserved Domains (4) summary
      smart00105
      Location:28137
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd01251
      Location:263368
      PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
      cd13252
      Location:141249
      PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
      pfam00169
      Location:266366
      PH; PH domain
    2. NM_001284309.2NP_001271238.2  arf-GAP with dual PH domain-containing protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon and initiates translation from an in-frame downstream start codon compared to variant 1. The resulting isoform (3) has a shorter N-terminus compared to isoform 1. Variants 3 and 4 encode the same isoform.
      Source sequence(s)
      AC073957
      Consensus CDS
      CCDS64576.1
      Related
      ENSP00000481154.1, ENST00000611167.4
      Conserved Domains (3) summary
      cd01251
      Location:180285
      PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
      cd13252
      Location:58166
      PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
      cl28907
      Location:141
      ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
    3. NM_001284310.1NP_001271239.1  arf-GAP with dual PH domain-containing protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001271239.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an exon at the 5' end and contains an alternate 5' terminal exon, which results in translation initiation from an in-frame downstream start codon compared to variant 1. The resulting isoform (3) has a shorter N-terminus compared to isoform 1. Variants 3 and 4 encode the same isoform.
      Source sequence(s)
      AI910700, AK092471, BC033747
      Consensus CDS
      CCDS64576.1
      UniProtKB/Swiss-Prot
      O75689
      UniProtKB/TrEMBL
      A8K3A2
      Related
      ENSP00000407267.2, ENST00000449296.6
      Conserved Domains (3) summary
      cd01251
      Location:180285
      PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
      cd13252
      Location:58166
      PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
      cl28907
      Location:141
      ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
    4. NM_001284311.2NP_001271240.2  arf-GAP with dual PH domain-containing protein 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks 2 exons at the 5' end and contains an alternate 5' terminal exon, which results in translation initiation from an alternate start codon compared to variant 1. The resulting shorter isoform (4) has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC073957
      Consensus CDS
      CCDS75558.1
      Related
      ENSP00000478011.1, ENST00000617043.4
      Conserved Domains (3) summary
      cd01251
      Location:157262
      PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
      cd13252
      Location:35143
      PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1
      cl29885
      Location:831
      ArfGap; Putative GTPase activating protein for Arf
    5. NM_006869.4NP_006860.2  arf-GAP with dual PH domain-containing protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1.
      Source sequence(s)
      AC073957
      Consensus CDS
      CCDS5318.1
      Related
      ENSP00000265846.5, ENST00000265846.10
      Conserved Domains (3) summary
      smart00105
      Location:10126
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd01251
      Location:252357
      PH2_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 2
      cd13252
      Location:130238
      PH1_ADAP; ArfGAP with dual PH domains Pleckstrin homology (PH) domain, repeat 1

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

      Range
      897900..955407 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center